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Possible Worlds

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John Burdon Sanderson Haldane was a giant among men. He made major contributions to genetics, population biology, and evolutionary theory. He was at once comfortable in mathematics, chemistry, microbiology and animal physiology. But it was his belief in education that led to his preparing his popular essays for publication. In his own words: "Many scientifi c workers believe that they should confine their publications to learned journals. I think that the public has a right to know what is going on inside the laboratories, for some of which it pays." So begins Haldane's collection of essays, perhaps the most public intellectual communicating science before the writings of Stephen Jay Gould.

352 pages, Paperback

First published January 1, 1928

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About the author

J.B.S. Haldane

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John Burdon Sanderson Haldane was a British geneticist, biometrician, physiologist, and popularizer of science who opened new paths of research in population genetics and evolution.

Son of the noted physiologist John Scott Haldane, he began studying science as assistant to his father at the age of eight and later received formal education in the classics at Eton College and at New College, Oxford (M.A., 1914). After World War I he served as a fellow of New College and then taught at the University of Cambridge (1922–32), the University of California, Berkeley (1932), and the University of London (1933–57).

In the 1930s Haldane became a Marxist. He joined the British Communist Party and assumed editorship of the party’s London paper, the Daily Worker. Later, he became disillusioned with the official party line and with the rise of the controversial Soviet biologist Trofim D. Lysenko. In 1957 Haldane moved to India, where he took citizenship and headed the government Genetics and Biometry Laboratory in Orissa.

Haldane, R.A. Fisher, and Sewall Wright, in separate mathematical arguments based on analyses of mutation rates, population size, patterns of reproduction, and other factors, related Darwinian evolutionary theory and Gregor Mendel’s concepts of heredity. Haldane also contributed to the theory of enzyme action and to studies in human physiology. He possessed a combination of analytic powers, literary abilities, a wide range of knowledge, and a force of personality that produced numerous discoveries in several scientific fields and proved stimulating to an entire generation of research workers.

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Profile Image for Patrick Stuart.
Author 18 books164 followers
October 6, 2023
This book is a lucid scrying pool amidst in the dark and murky inter-war years. It is like stumbling through a grey and misty land and discovering a cave within which crouches a wizard who gazes into clear and glittering pool crystal visions of a future time.

We are in that future time right now and it has turned out to be just as dark and murky as the bog around the wizards cave, but we can look upwards, at the point of view of his scrying pool, where presumably he looks down on us from the past, and wave 'Hello' to the Wizard.
We are looking at Haldane looking at us and that is where much of the interest arises.

THE TRENCHES

I read this based on its near-unanimous recommendation by anyone involved in the life sciences and I was surprised, (though perhaps I should not have been), to find another WW1 connection. As well as occupying seemingly every role possible related to genetics and biology in the inter-war years, Haldane was a WW1 veteran, a grenades expert with the Black Watch (for non-military and U.S. readers the Black Watch is generally considered a very high-competence if not elite regiment).
I would love to shove Haldane, the atheist communist, Studdert-Kennedy, the fallen Anglican and Sebastian Junger, the medieval knight and not-quite Fascist, all in a room together and have them talk it out. It would be a hell of a debate.

A VERY BEAUTIFUL MIND

'Possible Worlds' was originally a series of newspaper articles written for 'the ordinary man' 'in intervals between research work and teaching and largely on railway trains'.

These are about science, biology, the scientific life, the future of humanity and Haldane. Many are short, all are clear. A very blessed clarity considering the dithering and extemperous blathering and 'chummy' simplifications of much science writing both now and then. Haldane writes like a man who does not have much time and earnestly wants to get to the point.

Some are so simple and so clear and highlight or describe a concept so exactly that nearly 100 years later they are still being quoted mentioned and recommended today.

'On Scales' regards thinking about reaches or scales of time and distance far beyond our immediate ken. If you have watched the Sagan video, or its modern repetitions then you have seen a visual version of this essay.

'On Being the Right Size' is quoted or mentioned in many discussions of biodynamics I know of;
"You can drop a mouse down a thousand-yard mine shaft; and, on arriving at the bottom, it gets a slight shock and walks away, so long as the ground is fairly soft. A rat is killed, a man is broken, a horse splashes."

HALDANE AND TERRIBLE AND QUESTIONABLE IDEAS

Haldane had a lot of sketchy ideas, the most provably-awful are probably being a freestyle vivisectionist, a Communist and a Chemical Warfare enthusiast.

Haldane grew up experimenting on animals with his dad, he was quite willing to experiment on himself, to the extent of drinking dilute hydrochloric acid, sealing himself inside sealed atmosphere chambers and slowly removing the oxygen and attempting experimental diving suits at the age of 13, (not all at the same time). If you added some sadism and race-hatred he would probably have done well in various German or Japanese labs during the oncoming war, but Haldane had little hatred in him, and no sadism, he seems to have regarded the animals around him, and his own body, the way a farmer regards a horse or dog; useful, interesting, necessary, valuable, but not sacred. He reported that, (like Junger), he enjoyed killing people quite a bit. He was an explosives expert, wrote a book on the benefits of chemical warfare and thought it was stupid not to use more mustard gas than we did.

He belongs in that very slightly discomforting margin of humanity who will quite happily take living beings, including themselves, apart in laboratories and their fellow man apart in wars, but won't do it freestyle, for pleasure, for no reason or to anyone who asks them not to (except in war).
In 'Some Enemies of Science' Haldane recommends the complete deregulation of vivisection in the interests of science and of popular science.

"... I killed two rats in the course of experimental work intended to advance medical science. One of them, if we can judge from human experience (and we have no more direct means of evaluating the consciousness of animals), died after a period of rather pleasant delirium like that of alcoholic intoxication. The other had convulsions, and may have been in pain for three or four minutes. I should be very thankful if I knew that I should suffer no more than it did before my death. It therefore seems ridiculous that, wheras my wife" [she had poisoned rats] "is encouraged by the Government and the Press, I should be compelled to apply to the President of the Royal Society and other eminent man of science for signature to an application to the already overworked Home Secretary, before I can even kill a mouse in a slightly novel manner."

Haldanes arguments for the deregulation of Vivisection are strong, coherent, logical and possibly a little mad. His unrelenting hatred for the 'Anti-Vivisectionists' whose hypocrisy, delusion and hatred of science is stopping him from killing mice in novel ways, is genuine, deeply felt and extremely expressed. He is really outraged about the mouse-chopping.

If Haldanes Lassaiz-Fiare Vivisection policy had been made real, the results would have been interesting, but probably more bad than good. Mouse-chopping should be licensed.

Like most high-I.Q. lefties in the inter-war years, Haldane was a Marxist and a Communist. He was wrong and held on to the idea too long. You can tell how sane an inter-war western intellectual was by the date they stopped believing in Communism. Cordwainer Smith, Rebecca West and Bertrand Russel; quite soon, the French; never.

Haldane went full-Commie in the mid 30's, when the saner types were already leaving. He objected to Lysenkos imaginary genetics in 1949 but didn't leave and finally resigned from the Communist Party in 1956. In 1957 he resigned from being British over the Suez incident and went off to spend his final years in India. His stupid murder-god had failed in front of him, Britian was still masturbating to dreams of Imperialism so he took the third way. I think he was also attracted to India because it was here that the direct connection with nature, vast range of life and ability to deal with large populations was closest to the experimental world of his early youth. (He grew up as the son of an aristocrat-scientist the late 19th century.) By the mid 20th century the U.K. was even more intensely urbanised and Haldanes dream of widespread 'Citizen Science' based on animal collections, (and vivisection), and interacting with nature was looking less and less possible. But in India, more space, more nature, and a great diversity of people.

In 1925 he also wrote 'Callinicus: A Defence of Chemical Warfare', which I have not read but his defence of Mustard Gas in 'Possible Worlds' is based on the relative bodily destructive power of machine guns and Mustard Gas. His logic is very like that of the pro-Vivisection argument which is "If we are eating animals and hunting animals why can't I chop them up when I like since I have very good reasons for doing so?" "Likewise, if we are machine gunning each other and bombing each other (ask me how), why not gas each other since it will have the same effect & less human bodies will be destroyed in the process?"

Against Haldanes iron logic I can only offer the midwits response of 'I think that might not turn out the way you think it will'.

He was also an atheist, which I don't consider amongst his terrible and questionable ideas but it is slightly boring from a modern-day perspective, listening to him go on about it is a bit dull. Its interesting to hear from his perspective about how cowardly and useless most Christian Padres were in the war, even more interesting that he signals out for rare praise; the Quakers, for their Pacifistic ambulance-driving and more war service.

DON'T TRUST THE SCIENCE BRO

Haldane has largely (and inadvertently) convinced me that scientists shouldn't get involved in politics. They have no intuitive grasp on what politics is on any level, assuming it to be some kind of social machine to produce 'optimum results'.

They should be consulted closely on their special subjects, should not set policy and generally should be kept in special boxes far from the levers of power.

This applies especially to biologists and other life-science types, especially the more intelligent sort. Their deep understanding of the processes of nature and the human body has been bought at the price of any intuitive grasp of the meaning of nature or the human body and a scientist, if allowed near policy, if asked not to investigate but to decide, will proceed on the basis of optimisation towards a concrete goal, as if they were dealing with a malfunctioning machine.
This is not what society, a nation or humanity is.

Furthermore, there are politicians whom it is necessary to have make decisions and who must be fired afterwards. During Covid most possible choices carried serious moral hazard. Decisions had to be made. Those decisions would by necessity have terrible effects on someone. After the emergency had passed those decisions must be rejected by the very populations that required them and the decision-makers disposed of. This is unpleasant but it is the nature of things. If we had hyper-expert scientists actually making those decisions instead of advising on them, firstly they would proceed on the basis of blind optimisation as stated above, secondly when we inevitably had to turn against them after the emergency was over, we would lose, not a fundamentally-replaceable politician, but a useful expert, and finally because the necessary moral hazard of those choices would ultimately reflect not on one individual or administration but on the scientist and on science itself. Fauci, before he dies, may well drag virology in the U.S. back into the stone age, purely as part of the counter-reaction to his mistakes.

EUGENICS

We live in a new age of Eugenics, though we don't quite realise it yet.

Really, any form of Eugenics that becomes common enough stops being thought of as 'Eugenics'. It’s not a completely sliding scale but it’s pretty slippery. Condoms, I.U.D.s the Pill, sonic scans of developing foetus' and risk-free Abortions are all fruit of the Eugenic tree.

Hasidic Jewish populations are already using genome sequencing to avoid dangerous genetic combinations in their (arguably quite inbred) community.

Genome sequencing is becoming cheaper and cheaper, more and more accurate, and the power of algorithms to predict and control for certain desired qualities in the genome is becoming more and more effective.
(Reading between the lines of various Geneticists, its probably possible to run an algo on a range of IVF foetuses and select for high I.Q. Even though I.Q. is insanely polygenic and we have no idea how it works, the algo doesn't need to understand that and can just find relationships regardless. The reason this hasn't been done publicly isn't because it can't be done but because Geneticists are nuclear-avoidant of talking about it or doing it.

Theoretical - likely someone has already tried selecting IVF foetuses for I.Q. and these children have been born.)

Haldane only writes directly about this once in 'Possible Worlds', though as a Genetor-Prime of the British Empire, he knew as much about it as anyone of his generation, and as the ever-lucid and prescient Haldane, he could predict more than most of his generation.

In 'Eugenics and Social Reform', Haldane is.. mixed. Ultimately he thinks it’s necessary and probably inevitable but we shouldn't do it now as we don't know what we are doing and it’s probably more complex than we think.

On 'feeble-mindedness', the majority of which I take to be Downs Syndrome, Haldane might be surprised that it is not a hereditary problem, that we can't find it in the parents genes but can find it through embryo testing and more commonly, through scans, and that we are largely utterly ruthless in aborting the vast majority of such children. Perhaps he wouldn't be surprised. Perhaps our relationship with Downs Syndrome is more like how our relationship with Eugenics will proceed, not but grand unified programmes but by quiet invisible decisions made by parents in doctors offices, made with ever-increasing data and in invisibly-shifting social consensus, and made silently and not spoken of.

What Haldane seems to be saying is that the rich, intelligent and successful, inevitably put themselves out of genetic buisness by not breeding at a replacement level. They are always outweighed by the poor or common who breed a lot more. This seems to have been true in Haldanes time, looks to have been true for much of European history, and is true now. (Despite going on about this at length and being married twice, and being pretty well-off, Haldane had no children.)
Yet we still have rich, successful and intelligent people. Whether we have as much as we did in Haldanes time it’s hard to tell but it doesn't seem that different.

Probably we do not really understand how this works at all, especially on a larger scale and across deep reaches of time.

[REVIEW TOO LONG, MORE ON THE SUBSTACK OR BLOG]
Profile Image for Ella Cooper.
1 review1 follower
March 28, 2017
Fantastic book - some of the science is now of course inaccurate and has been disproved. However the way in which J.B.S Haldane portrays the concepts in this book are top class! Amazing to see the transition from then to now.

Enjoy
Profile Image for Betawolf.
390 reviews1,481 followers
July 23, 2017
A collection of mostly biological essays by Haldane, most seeming to have been previously published in the 1920s. Where he strays outside of biology, he tends to be doing so to advance a generally 'scientific' approach in matters of religion and politics, though he does demonstrate something of an interest in astronomy.

It's a mixed bag. Some of the biological essays are still informative about the basics of the field, though you'd be well-advised to have Wikipedia on hand to double-check some of the more dated concepts (something Haldane would appear to expect, being apparently sincere in his scientific humilty). It's impressive how forward-thinking Haldane was. As well as correctly anticipating a number of developments ongoing in his own time -- the development of a vaccine for tuberculosis, for example -- he routinely brings up topics which are even now at the edge of implementation.

Haldane talks about vat-grown beef, genetic sequencing of fetuses, genetic health as a direct factor for mate selection, biological immortality and practical eugenics -- all well before WWII. He also mentioned an intriguing and seemingly quite simple project for turning cellulose into digestible sugars, which, if completed, would allow mankind to consume hay (though for efficiency's sake, this might have to be pre-processed rather than built into our digestive system). I don't know whether to be impressed at his prescience or depressed at how slowly we work.

Not all of the essays are very good. Predictably, the ones more remote from his expertise are the least reliable -- his essay on Kant as underlying scientific work was quite unintelligible, his position on spiritual matters seemed to fluctuate from essay to essay, and a few of the broader and shorter articles were bordering on the pointless or obvious. Possible Worlds itself was a piece of armchair philosophising quite contradictory to his earlier discussions of empiricism, and I didn't enjoy it very much. His The Last Judgement was a more entertaining attempt at science-fiction, but his estimation of the future of space travel was laughably primitive -- magnificently advanced and life-valuing future civilisations nevertheless endure thousands of deadly rocket-crashes in touching explorers down on other planets.
Profile Image for Richard.
770 reviews31 followers
October 18, 2025
I confess that until an author of I book I was reading referenced him, I had never heard of J.B.S. Haldane. According to Wikipedia, Haldane (1892–1964) “was a polymath who made important intellectual contributions to several sciences including physiology, genetics, biochemistry, statistics, biometry, cosmology, cybernetics, and others, all accomplished while possessing no university degree in any branch of science.”

The first thing to note is that this book was published in 1927 - nearly one hundred years ago. With the speed that scientific discoveries are appearing it would seem that such a book would be hopelessly dated. In fact, much of what Haldane writes about is as pertinent and accurate today as it was a century ago.

Of course, there are definite differences between what he wrote then and current publications. Haldane, like so many of his age, was obviously anti-semitic. Women along with people of races other than white bear little mention in his writings. As a vegetarian, I was not enamored of his comments about those of us who value animal lives. In too many ways, he comes across as a stereotypical, pompous Englishman.

If you can put those issues aside, ascribing them to his place and time, Haldane has a lot to say that is very pertinent today. His several essays on religion vs science are excellent, his loyalty to Darwin obvious, his questioning of any belief that is stated as fact is wonderful, his anti-war sentiments resonate well, and his comments about many famous scientists are illuminating.

So, if you can take the attitude of not throwing out the baby with the bathwater you will find that Haldane has much to say that is as relevant today as when he wrote it a century ago.
Profile Image for Maksym Shcherban.
77 reviews
June 4, 2022
A fun and refreshing collection of popular science essays from the first half of the 20th century. Always interesting to learn how our ancestors envisioned the future. While most predictions made in this book came to be more or less accurate, some were hilariously off. To give one example, the author hypothesized that in 20 million years humans will colonize Venus, and in doing so, out of 1700 rockets sent to Venus only 10 will reach their destination :D
2 reviews
Want to read
March 20, 2020
I want to understanding that how are Haldane describe possible worlds
This entire review has been hidden because of spoilers.
Profile Image for Kyle Reed.
4 reviews7 followers
July 8, 2015
I was amazed at how prescient this book is.
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