On the one hand, this is an unsparing look at the current (as of 2011) state of science in the age of commercialization. Although Mirowski's basic story of the increasing commercialization of science since the early 1980s is nothing new (either to him or in general), there is plenty here even for those who are familiar with the topic. Mirowski presents new research about the state of scientific publications, patents, and other intellectual property mainstays such as material transfer agreement. One of the more interesting aspects of his story here is the widening of commercialized science from the biotechnology sector to nearly ever other corner of science. His analysis links the commercialization of science to neoliberal ideologies and program, and he simultaneously demonstrates the errors, omissions, and deceptions of neoliberalism.
On the other hand, what I least like about Science-Mart, and this goes for Mirowski's writing in general, is his dismissive attitude towards much of STS, philosophy of science, and the economics of science. His approach often seems to carpet-bomb neoliberalism and anybody he sees as a collaborator, rather than to offer any substantive engagement. Similarly, his literary device of lecturing to Viridiana, his bewildered imaginary scientist, struck me as condescending rather than as an inviting way into the topic for the non-initiated.
Finally, I found his last chapter quite unsatisfying. It was his shortest chapter, both in length and in analysis. While I agree that the active promotion of ignorance, as studied by the emerging historical field of agnotology, is an important component of neoliberalism, his characterization of Hayek's and neoliberalism's views towards ignorance was highly unconvincing. I doubt Hayek or anyone would espouse the beliefs he attributes to them, even privately.