Hiruma has to come up with a plan to stop Mamori from interfering with Sena playing on his American football team, the Deimon Devilbats. Mamori just wants to protect Sena, and she doesn't want him around the dangerous Hiruma (even though she doesn't know he's playing IN the game as the amazing running back Eyeshield 21), so she is allowed to join as secretary to keep her eye on them. After having beaten the Koigahama Cupids in the previous volume, the Devilbats are now up against the White Knights from Ojo. There's no way they can win because Ojo has Shin--an incredible light-speed running back who can rival Sena's speed. Shin is powerful and really means business, and when Sena hears horror stories about how badly other players have been injured playing against him, he wants to back out and stop playing. But team spirit gets to him and he enters the game anyway. Things look promising when Shin isn't in the game--he's on the bench--but then he gets sent in and makes short work of Sena over and over again. Hiruma declares a win hopeless, but even if they can't win, Sena still wants to try again to get past Shin. . . .
One great thing about this manga is that it features the "villains"--the other teams--as sympathetic characters as well. Shin has flaws (for instance, he can't use electronics without breaking them) and is dark and obsessed, but has an amazing ability to analyze other people's movements and saw right through Sena's eyeshield disguise (so he knows what his real identity is). I love that Sena admires him even though they're on opposite teams. Interesting also are the stories behind other major Ojo players: Sakuraba, a tall wide receiver, is better known as a screen star and looks like a model, so everyone wants to take his picture and bill him as the hero of the team, but he knows Shin is the team's real ace and he's only advantaged somewhat because he's so tall. And their quarterback, Takami, is a physically disadvantaged player because an injury from his childhood prevents him from running, but his phenomenal calculations allow him to throw the ball with precision. Another thing that's wonderful about this manga is that the good guys sometimes lose. If a team called the Deimon Devilbats with a demonic quarterback can be considered the good guys.