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371 pages, Kindle Edition
First published January 1, 2011
Before the human genome was sequenced...the conventional wisdom was that one gene makes one protein, and since humans have 100,000 proteins, they must have 100,000 genes. This was pretty much considered to be a fact. But when the sequence was obtained, the number of genes was only a quarter of that. This unexpected discovery drove home a message that biologists already knew, but had not fully taken on board: genes can be chopped up and reassembled when proteins are being made. On average, each human gene makes four proteins, not one, by exploiting this process.