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The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands

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Taking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable.

We are on the cusp of a major transformation in healthcare—yet few people know it. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”—the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine.

Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little or no benefit to most people taking them. Leroy Hood and Nathan Price argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health—a form of highly personalized care they call “scientific wellness.” Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. Current applications have shown startling diabetes reversed, cancers eliminated, Alzheimer’s avoided, autoimmune conditions kept at bay.

This is not a future it is already happening, but only for a few patients and at high cost. It’s time to make this gold standard of care more widely available. Inspiring in its possibilities, radical in its conclusions, The Age of Scientific Wellness shares actionable insights to help you chart a course to a longer, healthier, and more fulfilling life.

342 pages, Kindle Edition

First published April 4, 2023

113 people are currently reading
860 people want to read

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Leroy Hood

13 books3 followers

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Displaying 1 - 30 of 32 reviews
Profile Image for Asya Paloni.
6 reviews
November 29, 2023
Got a bit repetitive but there’s a certain charm to a couple of nerds getting a little rambly because they got too excited
Profile Image for Tea and Spite.
415 reviews12 followers
June 29, 2024
I usually try not to rate my DNFs unless I've hit at least the 50% mark, but oh my god this one had me in such a rage that I just can't let it go.

Look, I like data-driven medicine and all the cool advancements in medical technology. It's awesome, it's fun, it's a great area to study.

But there is so much more to human health and longevity than the simple mechanics of molecular biology. Hood spends a lot of time talking about preventing epidemics of obesity, type two diabetes, alzheimers and other diseases largely considered illness of the modern world. The sorts of things that didn't really exist until people regularly started living into their 70s and beyond. That's great, that's the goal of pretty much anyone working in public health or medicine at the moment.

However, we already have a solid idea of how to do that and it does not involve tracking every single health metric and undergoing individual genome sequencing. The reality is that all evidences points to genetics playing only a minor role in longevity and overall health. Environment is a far greater factor.

You want to live to a ripe old age and still be healthy enough to enjoy it? There are some very simple steps you can start working toward right now to help get you there:

- Eat a varied, predominantly plant-based diet. Bonus points for organic produce and grass-fed, free-range meat and dairy. Check out Pollan's In Defense of Food for a solid examination of this.
- Engage in regular physical activity, whether that's gardening, walking, dancing, or hitting the gym. Aim for a minimum of 150 minutes of moderate aerobic activity per week (can carry on a conversation, can't sing) or 75 minutes of vigorous aerobic activity (can't converse without stopping for breath), plus strength training. (Pro tip: if you are a dedicated couch potato, activities like carrying multiple loads of laundry upstairs or using a push mower to mow your lawn will get your heart rate up without adding another chore to your task list.)
- Keep your brain working. Learn a language, read widely, take up chess, start oil painting. The goal is just to keep trying new things so your brain continues forming new connections.
- Stay social. The single biggest indicator of longevity and health for retirees isn't diet or exercise, it's social engagement. You are more likely to have a healthy old age if you have a community around you. It can be church, family, or your local D&D group as long as you're regularly forming positive connections.
- Build healthy coping mechanisms. Keep a diary, get a dog, meditate, take up tai chi. Developing healthy ways of dealing with the stresses of life is another key indicator of health and longevity. Fortunately, hobbies, exercise, and social supports are all buffers against the worst impacts of stress.

That's it. No DNA sequencing needed. There are genetic factors that determine how susceptible individuals are to environmental influence, but it's both more effective and more cost efficient to fix the environment than it is to scare people by going on about how their genes show a higher probability of this illness or that one. For the overwhelming majority of the population and the overwhelming majority of illnesses, DNA is not destiny. Environment matters.

How do we know this? We can compare comparable populations. Children of Japanese immigrants are more likely to be obese than their relatives still in Japan. Japanese-Hawaiians, whose genetics do not substantially differ from those of Japanese in Japan, have significantly higher rates of obesity, type 2 diabetes, hypertension, and dementia. To focus on biometrics is to fundamentally disregard the social determinants of health.
Profile Image for Richard.
235 reviews12 followers
June 2, 2023
Also see this review.

The authors are pioneers in the field of systems biology, which aims to understand the complex interactions among biological components at different levels of organization. They argue that by applying a systems approach to human health, we can achieve P4 medicine: medicine that is predictive, preventive, personalized, and participatory.

The book is based on the their experiences in founding and leading the Institute for Systems Biology (ISB) in Seattle, and launching Arivale, a scientific wellness company that offered a subscription-based service to measure and optimize various aspects of health for thousands of individuals. The book also draws on the latest scientific discoveries and innovations in biotechnology, genomics, proteomics, metabolomics, microbiomics, and artificial intelligence. The book is full of fascinating stories and examples of how scientific wellness can help people prevent or reverse chronic diseases, slow down aging, enhance brain function, and improve quality of life.

The book covers a wide range of topics, from the history and principles of systems biology, to the key ideas and technologies that enable scientific wellness, to the applications and implications of scientific wellness for various health conditions and challenges.

Written in an accessible and engaging style, there are clear explanations of complex concepts and technical terms. Although intended for a general audience, it also provides enough depth and detail for readers who want to learn more about the science behind scientific wellness.

The authors cover a lot of territory in a relatively short space, which means that some topics are not treated as thoroughly or evenly as others. For example, the book devotes more attention to Alzheimer’s and cancer than to other diseases or disorders that could also benefit from scientific wellness. Moreover, they don't explore enough the potential of artificial intelligence, especially generative models such as GPTs (Generative Pre-trained Transformers), which could revolutionize the analysis and synthesis of biological data.

Still, this is a must-read for anyone who is interested in learning about the cutting-edge science and technology that can enable us to live longer, healthier, and happier lives.
Profile Image for Rosalyn Brown.
167 reviews2 followers
March 30, 2024
This book sparked a curiosity within me to explore the depths of my own biology by considering genome sequencing. The idea of unraveling the intricacies of my genetic makeup felt empowering, offering insights into potential health risks and personalized treatments.

However, the journey doesn't end with curiosity. "The Age of Scientific Wellness" sheds light on the unfortunate disparities in access to such groundbreaking technologies. It's disheartening to realize that in some countries, genome sequencing is becoming a standard while in others, like the United States, it remains largely uncovered by insurance.

This book serves as a call to action, urging us to advocate for equitable access to scientific advancements in healthcare. It's a compelling read that not only educates but also ignites a sense of responsibility towards shaping a future where personalized healthcare is accessible to all.

Highly recommend for anyone intrigued by the intersection of science, health, and equity.

And if you have had your genome sequenced tell me where? And how was it?
Profile Image for Brandon.
184 reviews1 follower
June 29, 2023
This is an interesting book that excites with its view of an improved version of healthcare through a P4 lens: personalized, predictive, preventative, and participatory. My biggest critique is that I don't believe this book is as accessible as it should be. I think the authors make large assumptions about the scientific and biological backgrounds of their readers. That being said, I learned a lot and hope that many of the ideas regarding the use of multiomics in everyone's healthcare journey comes to fruition.
102 reviews8 followers
July 5, 2023
Some really important info in here about the future of medicine - focusing on health span and wellness rather than treating problems when it is too late. However, it was very repetitive and could have used a good editing. Still, I think it is a necessary read.
Profile Image for Livvy.
318 reviews2 followers
November 7, 2023
3.5: Very informative read but very very dense.
Profile Image for Rakhi.
Author 2 books97 followers
October 8, 2023
Health is the state of being well and free from illness. Science has outgrown every expectation and medicines for every ailment have been in place and to improve healthcare quality. Longevity has touched heights and life expectancy is also high. But are we leading a quality life? In this era of AI, it is treating diseases enough. The Age of Scientific Wellness by Leroy Hood and Nathan Prince is a comprehensive study of how we should be proactive rather than reactive.

How to improve healthcare quality - Leroy Hood and Nathan Prince don't mince the words

The book aims at enabling us to optimize our health. With the suggestions of unprecedented techniques the authors open a new world of health in front of the readers. The world is open to treatment of symptoms and proudly beam in the technological advancements that we have never seen before. But are we indeed aware of the real 'technology' available to us? But extending our health span in comparison to the yester years are we indeed way ahead in science and technology? Apparently we are but we are not aware of the real cutting edge technology available to us. 

Only a minority knows that with AI empowered technology and genome sequencing, we can predict the disease years before the symptoms arise. With this technology, it is even possible to eliminate cancer and effectively address diseases like Alzheimer's even before we know it. The sad reality is that only the rich and privileged have access to the technology as it is available at an exorbitant price. But don't we deserve to know what is available for us.

The proactive steps to improve healthcare quality

The authors of the age of scientific wellness aim at providing the information at the fingertips of the readers. The information available in the book are priceless and I bet you would drop your jaw to know that some of the dystopian fantasies are indeed a reality. However the authors identify the reality that we are not ready for a robot overload and urges to find an interim solution.

The language of the book is too technical for a layman to process. If someone with no knowledge about the medical field reads this, they will be lost among the jargons. For someone who is keen at knowing the advancement in the medical and scientific field the book is a treasure to keep. With the slow pace of information flow, the book is sure to remain relevant for another two decades. An important highlight of the books is that it gives us practical solutions which we can try right away - diet, exercise, sleep and stress management. Also if we have any known family history we could try to alter our lifestyle to prepare ourselves for an impending lifestyle disorder. The book holds so vast information that the readers would have something or the other to relate to with respect to their loved ones or the ones they know.

No medicine is better than ineffective medicine

While I deal with my clients of wellness programs, some of them chose to ditch their medicine and go forward with the wellness routine. However, I suggested them to continue their medication as I was no one to decide on the possible positive or negative repercussions. However, some of them felt better without medications and some had to go back to their psychiatrists. While I reviewed Young Mental Health by Meera Haran Alva and Amrita Tripathi, we also came across various case studies.This forced me to zero in that sometime ditching the medicine can be helpful but not always.

The authors bravely challenged the inefficacy of some medicines and despite having the risk of a painful final days the author's partner stopped the medicines and got better. However , the discretion of the readers is imperative in this case and it would be puerile to reach an assumption without reading through the book. With a careful approach the book could help you look out for various avenues to improve healthcare quality especially for terminal illnesses like cancer and neurodegenerative conditions like Alzheimer's.
34 reviews
July 27, 2024
There is an interesting tension at the heart of personalized, preventive medicine. Disease prevention does not require personalization (exercise, diet, and sleep pretty much work for everyone). And personalized medicine is not preventive (we are only willing to pay for expensive, personalized molecular data when it's already too late). The only stage of disease progression where the two meet is in the middle: just enough worry to pay for personalized data, and just early enough to prevent full-blown disease. This is a very narrow window of opportunity.

And as the anecdotes from Arivale show, even when data is able to clue us in on impending disease, there are no truly personalized treatments! Just a firm reminder to pay more attention to the fundamentals of good health: exercise, diet, sleep.

I wholeheartedly believe in the future of data-driven medicine: where we can transfer the biological insights learned from preventable chronic diseases to ones which are less preventable, such as aging or long COVID. But prevention is a problem which does not require personalization, prediction, nor data. Only participation.
2 reviews
January 16, 2025
My fastest DNF ever - I made it to 14%. I'm leaving this comment mainly to mark my word: the authors predictions of personalized medicine for all will not come true in the 50 year timeframe they predict.

Their first assumptions are patently false. Modern medicine does not 'wait for something to go wrong' before trying to fix it. So many counterexamples come to mind: LDL/cholesterol lowering meds (e.g. statins) are begun at first sign of hypercholesterolemia, decades before any ACS. Same with treating hypertension. Physicians also discuss the importance of active lifestyles, exercise, sleep, and smoking cessation with their patients prior to onset of any associated disease state.

The biggest challenge for medicine in the next 50 years will be providing the above standard of care measures equitably to all regardless of income, SES, and geography. Summoning AI and -omics technologies has not, and will not, change this fact.

It is ironic that the authors mention Linus Pauling and vitamin deficiencies so early in the book. I fear that this work will leave the same stain on Dr. Hood's legacy that Vitamin C left on Dr. Pauling's.
Profile Image for James Alvarez.
9 reviews
November 19, 2023
Healthcare is broken. Anyone that knows anything about healthcare knows that. I spent a decade working in the industry, so I’ve seen it firsthand, and it can be very depressing to think about. This book provided a glimmer of hope that we might soon be able to turn the page into a new age of healthcare, driven by big shifts in technology and ways of viewing our health. I loved this book, and although it was filled with loads of information it was well written and was an easy read. If you’re curious about what the future of healthcare might look like, and/or you want to know where the opportunities might be, then this is a great book to read.
Profile Image for Martina.
135 reviews15 followers
November 29, 2023
I was admittedly reluctant to buy this book because of my distaste for Big Pharma and the de-humanizing, dis-empowering, and wasteful administration of "health care" in the United States. To my pleasant surprise, the book eschews these failed models and calls for a paradigm shift toward preventing chronic diseases rather than waiting until patients are already sick. The new paradigm also puts more autonomy and power into the hand of people to positively affect their health through actionable lifestyle modification before (largely useless or harmful) medical treatments and drugs become necessary.
8 reviews
November 2, 2024
I’m a data strategist in healthcare and a firm believer in personalized medicine and data driven healthcare. I wish I could be more positive about the review of this book but, I can’t. It talks a lot about what’s possible and visionary but not how to do it and make it scalable and available to the broad population in the US. There’s no discussion of national policy which is necessary for the vision in this book to be achieved.
Profile Image for Dr. Ashori.
226 reviews6 followers
July 22, 2023
I stopped reading 60% into the book.
I'm not the right audience for a book basing advice on research on rats and mice and dogs and suggesting NAD supplements. With more funding and data the author's believe we'd get there. I think some of the science they share is interesting but I think we've tortured about animals without much advancement in medicine. .
Profile Image for Charles Reed.
Author 334 books41 followers
January 5, 2024
83%

I was just talking about Wellness and healthspan with my new physician friend so this was a nice thing to touch on.
Using this and going over my jeans I think to myself well you know prevention really is the Hallmark cure to disease, so let's make sure that we focus on our wellness and that means drinking enough water staying active and having a healthy well-balanced diet.
Profile Image for Carol.
974 reviews
October 11, 2025
A look at what might be more personalized medical care in the near future given science's ability to quantify more of our lifestyle and body markers added to the enormous advances in computing (including AI). There are some very real privacy concerns. But only by looking at the range of data can we tease out the forerunners of disease and aging.
Profile Image for Eric Jain.
19 reviews2 followers
May 24, 2023
The authors make a very clear case that we can and should address diseases before symptoms appear, introduce us to efforts (some failed, some ongoing) to get us there, and tell us what we as individuals can do today.
Profile Image for Jackie Kearney.
117 reviews2 followers
August 4, 2023
A lot of this went over my head, but I am so glad smart people think about these things. Is sticking with me in terms of what I request for my health in the future and what I do to prevent illness. You could probably get the gist by listening to a podcast-I didn’t need to read the whole book.
Profile Image for Joshua Glucksman.
99 reviews9 followers
June 3, 2024
Literally fell asleep reading this, so boring. But this is probably the guys most will take seriously in the turn to personalized / AI medicine. Literally so done with this shit for rn, time for some bible
Profile Image for Dani.
56 reviews
October 26, 2024
The authors’ collective vision for the future of medicine is astonishing. The information presented in this book is incredible, although it did get a bit repetitive and over my head toward the end. Despite this, I highly recommend this book.
Profile Image for Keri.
5 reviews
March 28, 2025
It’s an interesting concept. At times it is exactly the kind of healthcare treatment I would want. When it comes down to it, it is not something I’m willing to pay for on top of my insurance premiums. Also, would I really listen to the advice if they tell me not to eat chocolate anymore?
Profile Image for Ariel.
7 reviews
May 5, 2025
Reads like a lengthy essay, a call to action convincing the reader why healthcare needs to change. I believe that’s its niche and it does it well. We need to many many many people in board about changing the way we do medicine before we can actually make some changes about it
Profile Image for Madison Pittman.
36 reviews
August 14, 2023
Great book. Very insightful. A little repetitive and I got the gist early on. Additionally, I didn't feel like I came away with super specific next steps.
Profile Image for Dave Tubridy.
14 reviews
August 30, 2023
An interesting topic and a very knowledgable author but I found the book highly detailed, repetitive and not very engaging to read.
Profile Image for Kristel.
612 reviews1 follower
January 4, 2024
Good forward thinking information about health and health care.
23 reviews
June 17, 2024
some useful information that we can all benefit from regardless of age.
Profile Image for Celeste.
42 reviews
December 13, 2024
It gave me a new perspective on wellness and healthcare. I really enjoyed this book!
Profile Image for Robin Pond.
1 review
February 1, 2025
2.5 stars. Very informative but WAY too long for what it was. Was very repetitive
Displaying 1 - 30 of 32 reviews

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