This books is a mix of proven fact, unproven but rational ideas, radical ideas, and out-right false information and opinions. The real problem with the book is that there is no way to note which is which and his references at the end of the book are just a list of books with no way to link it to what the author claims in the chapter.
The basic gist is good. Balance the enzymes in the brain for better brain function. Everyone really knows what he is telling you to do: 1. Be aware of how well your brain is functioning; 2. Meditate and learn to relax; 3. Eat whole foods, lots of veggies and fruit, and lean meat; 4. Do brain boosting exercises and physical exercise; 5. Get hormone replacement therapy for areas your lacking (and there is a lot of false and unproven stuff in this chapter); and 6. Take medication as needed. While it sounds good, the author puts so much other information and contradictory information that it weakens everything else he writes.
At the beginning of the book, when he would claim things that I was fairly sure to be false, I started looking it up. Some of the things he will tell you is that a well functioning brain will have no issues driving while talking on a cell phone, extended estrogen use does not have any link to higher risk of breast cancer, and Parkinson's disease can be cured with dopamine (research shows it declines after time). There are a ton of other things and I didn't take notes or this review would easily run through the characters allowed.
Some of the claims that are not proven to be outright false but are certainly questionable is that extroverts are smarter than introverts, that the vitamins and supplements that are more expensive and that he makes are inherently better than other ones (but oddly he doesn't claim to be certified as having current good manufacturing practices - though he mentions that of course he follows them), and that following his protocol anyone should be able to have perfect (or close to it) memory in four different areas.
Add to all that and there is the condescending tone that this is written in and his disdain for anyone that might disagree with him. He even makes a statement to take this book with you to your doctor and point out all the places that your doctor might disagree to change your doctor's mind. He uses chemical and medical acronyms without defining them. He also describes the biochemistry of things in a manner much more complex (and sometimes therefore not quite accurate) than in necessary.
I would never recommend this book to anyone because it has so many flaws. I would, however, recommend some of the same things the author suggests, which is why I gave it two stars instead of one.