Ratfist started life as a webcomic, though I wonder how many people would have guessed it was if Doug TenNapel didn't say so in his afterward. Like Earthworm Jim before it, Ratfist is a goofy take on the superhero genre; indeed fans of EWJ will recognize the cartoon humor juxtaposed with weird, and sometimes gross stuff. That said, Ratfist goes into heavier subject matter than the EWJ video games ever did (the graphic novels are another story, but I digress).
Simply put, the story of Ratfist is about the transformation of Ricky, who works a corporate job by day and is a masked vigilante by night. Ricky is dating a woman named Gina who is deathly afraid of rats, which proves problematic because during a nighttime mission, Ricky accidentally absorbs a rat in a freak accident and becomes a rat-man hybrid. Naturally, Ricky wants to revert to his old self, and he thinks his employer has the antidote, which has ties to some spurious secret experiments. From there, we're treated to a rabbit hole of pagan gods, mad science, dystopian futures, and a talking rat tail?
It's a fun premise and the art is, as one can expect, well-executed. The story is decent and has its moments, though TenNapel gets pretty self-indulgent in this book. Earthworm Jim cameos, characters break the fourth wall, TenNapel inserts himself into the story, and there's a fair amount of religious and sociopolitical commentary. That last one will definitely be a turn-off for some readers, especially since Ratfist gets a bit didactic with it (remember to vote in the next election, kids!).
Ratfist has a fun premise and Ricky's transformations, be it a rat-man or his transformation from a selfish man to a selfless man make for a solid story. TenNapel clearly had fun making this comic, even though he got a bit carried away with the messaging. I liked Ratfist well enough. That said, I think it's safe to say that with any book by this author, your mileage may vary.