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Bromocriptine: An Old Drug with New Uses

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Bromocriptine is a dopamine agonist drug (meaning that it acts like dopamine in the brain) that has been used for over three decades for the treatment of a number of conditions such as Parkinson’s disease, acromegaly (the disease Andre “The Giant” had), and overproduction of the hormone prolactin. You may be wondering what this has to do with the topic of body composition.

As I discuss in many of my articles and other books, the body regulates factors such as body weight, composition and appetite through a variety of hormones such as insulin and leptin. It turns out that those hormones exert at least part of their effect through dopamine levels in the brain. When people diet, dopamine levels drop in the brain and this is responsible for many of the effects (such as lowered metabolic rate, increased hunger, etc.) that occur.

My book Bromocriptine starts by outlining the systems that regulate body weight and fat levels before explaining how the drug bromocriptine can ‘trick’ the body into thinking that it’s not dieting so that metabolic rate doesn’t slow, hunger is decreased, etc. Side effects, dosing and everything else related to the drug and how it can be used for various purposes related to body composition are outlined in detail in the book.

Table of Contents

Chapter 1: Defining the Problem
Chapter 2: How your Body Knows
Chapter 3: Leptin Resistance
Chapter 4: Bromocriptine
Chapter 5: What Bromocriptine Does
Chapter 6: How Bromocriptine Works
Chapter 7: Using Bromocriptine, Part 1
Chapter 8: Side-effects and Risks
Chapter 9: Using Bromocriptine, Part 2
Chapter 10: Miscellaneous Miscellany
Appendix 1: The FDA and Bromocriptine
Frequently Asked Questions
References Cited

132 pages, Spiral-bound

First published January 1, 2002

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About the author

Lyle McDonald

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Profile Image for Joe.
42 reviews10 followers
February 4, 2018
Read this in 2013. Had forgotten a bunch of details. Re-read it yesterday and today. This book explains the real problem with dieting, as most of Lyle McDonald's writings do. It's a shame that he isn't mainstream. People need to concentrate a bit to read this. And they aren't told what they want to hear. That's why this isn't so accessible. But it isn't that hard to understand.

This book explains how the setpoint in the brain works. How we know how to lose weight effectively. What we don't know is how to keep the weight off. We always gain back the weight due to the setpoint in the Hypothalamus, signaled by Leptin. Which causes metabolism to change and hunger to spike.

Additionally, this book is a must-read if you are diabetic. He explains well why that's so challenging.

Finally, he explains the mechanism of how the setpoint screws you up and how to use Bromocriptine to "fix" it. A hack really.

I tried it in 2013 but stopped because of the side effects. Going to try again now, but slowly increase dosage. Hit me up if you want to know how it went. Wish me luck!
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