How does caffeine work its magic?
As long as we are awake, our brains are working hard. Our senses soak up data from the world around us… All of this information is reported to the brain by special cells called neurons.
With each bit of information we process, millions of neurons are active. The problem is, much as a running motor generates exhaust fumes, all of this neural activity leads to a serious buildup of cellular waste products. Eventually our cells need a nap. Neuron "exhaust" takes the form of molecules, including one called adenosine. Prompted by the adenosine buildup, our bodies nudge us into bed when our batteries need re-charging.
Anyone who has struggled to stay awake while driving knows the relentless pressure adenosine exerts on us to stop and sleep.
Adenosine itself doesn't cause the sleepiness; it's a messenger that simply signals the surrounding cells to settle down. Caffeine blocks this sleepy message. Here's how.
Our brain cells communicate by passing chemical messages like adenosine to one another. Messenger molecules are teamed up with specific listeners—called receptors—on other cells.
Adenosine and its receptors are exquisitely matched, like tiny locks that open only with the proper miniature key. When a cell releases adenosine, it fills adenosine receptors on nearby cells, passing along the message to sleep.
As the production of adenosine continues throughout our day, more and more receptors are filled. Increasingly our brain cells become sluggish, regardless of how strongly they are stimulated. We become tired. As we sleep, the night shift sweeps the adenosine away. When we wake, we feel better because we literally are more clear-headed.
Alcohol is the great impersonator, fooling at least four different receptor molecules. In a quick survey of the functions of these victims, we can see exactly how alcohol works its magic.
1. It slows us down, "relaxing" our neurons. By blocking receptors for our brains' chief excitatory neurotransmitters, alcohol coats the brain in a bit of molasses, slowing reaction times and slurring speech. We could probably do without this effect.
2. It gives us a pleasant buzz. Acting like cocaine — but much weaker — alcohol blocks dopamine reuptake, increasing the concentration of the happy neurotransmitter in the key parts of our brains.
3. It blocks pain. By stimulating the release of endorphins, alcohol lets us sample the "runner's high" without even putting on our running shoes. Resembling morphine and heroin in this respect, but again at a greatly reduced magnitude, alcohol spurs our body to produce a little opiate-like high.
4. Alcohol makes us happier, at least while if's in our system. Like a "do-it-yourself Prozac kit," alcohol modifies and increases the efficiency of our serotonin receptors.