This book introduces basic and fundamental programs of Python Programming, and it is simple and easy to understand for beginners. Here, I'll discuss how Python is comparable to other programming languages like C, C++, and Java, with the exception that the reserved term has been modified to set it apart from other languages. Variables, Input-Output statements, looping, decision-making, arrays, strings, numpyarray, list, tuple,functions, files etc. are also included in Python. This Book presents Python's user input, output, looping, decision-making, array, functions, characters, strings, tuples, lists, functions and files as well as code testing, in a way that is more approachable, painless, and efficient. This book is made up of large number of programs with clear and easy explanation. This book helps to give more information for B.Tech (CSE, IT and other branches), M.C.A, B.C.A, B.Sc (Computer Science), M.Sc (Information Technology) students of various universities.