When still a boy, Brinnin's parents moved to Detroit, Michigan. Brinnin went to the University of Michigan for his undergraduate studies where he won three Hopwood Awards in 1938, 1939 and 1940. He worked his way through school in an Ann Arbor book store. During part of this time (1936–1938), Brinnin served as the editor of the journal Signatures. Graduating from Michigan in 1942, Brinnin went to Harvard University for graduate work.
From 1949 to 1956 Brinnin was Director of the Young Men's and Young Women's Hebrew Association Poetry Center, popularly known today as the 92nd Street Y. While there he raised the center to national attention as a focal point for poetry in the United States. He was, for example, the first person to bring Dylan Thomas to the United States and his 1955 book Dylan Thomas in America describes much of his attempt to befriend and help the troubled Welsh poet.
In addition to his work on Thomas, Brinnin published six volumes of his own poetry. Brinnin also wrote scholarly works on T. S. Eliot, Gertrude Stein, Truman Capote, and William Carlos Williams; and published three personal travelogues.
Brinnin taught in a number of universities over his career. At various times, he gave courses at Vassar College, Boston University, the University of Connecticut, and Harvard University.
Brinnin died in Key West, Florida on June 25, 1998. His papers were left to the University of Delaware.
Oh sure there are a few plays I would've added -- "A Curtain Raiser," "Bonne Annee," and "Capital Capitals" -- and one that I would've dropped -- "Say It With Flowers" -- but having expressed that, this is an excellent anthology showcasing the scope of Stein's theatrical writings whether she's experimenting with the use of a period ("They Must. Be Wedded. To Their Wife.") or reinventing a classic ("Doctor Faustus Lights the Lights"). Even her operas "Four Saints in Three Acts" and "The Mother of Us All" read well on the page.