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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result.
Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms that underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
The third edition of The Molecular Biology of Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms that drive cancer is leading to the development of new targeted therapeutic
agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer.
Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
Written with students in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject--and an appreciation of
how a theoretical understanding can be transformed into therapeutic benefit.
The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease--and uncover possible solutions for its effective control.
COMPANION WEBSITE (www.oup.com/uk/orc/bin/9780199577170)
For
* Hyperlinks to primary literature articles featured in the text
* News feeds relevant to cancer biology, drawn from a variety of publications
* A web link library, giving access to relevant online resources
For
* Downloadable figures from the book
* A Test Bank of questions, with feedback linked to the book, for use in formative or summative assessment (password-protected)
Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms that underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
The third edition of The Molecular Biology of Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms that drive cancer is leading to the development of new targeted therapeutic
agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer.
Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
Written with students in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject--and an appreciation of
how a theoretical understanding can be transformed into therapeutic benefit.
The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease--and uncover possible solutions for its effective control.
COMPANION WEBSITE (www.oup.com/uk/orc/bin/9780199577170)
For
* Hyperlinks to primary literature articles featured in the text
* News feeds relevant to cancer biology, drawn from a variety of publications
* A web link library, giving access to relevant online resources
For
* Downloadable figures from the book
* A Test Bank of questions, with feedback linked to the book, for use in formative or summative assessment (password-protected)
360 pages, Paperback
First published January 1, 2005
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118 people want to read
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Displaying 1 - 4 of 4 reviews
April 6, 2025
Managed to find it at the local university library. Quite technical for a non-medical person like myself. But I did note many interesting aspects while reading the most digestible parts:
> The chemicals from sunscreen are cancer producing (photosentisized carcinogen)
> Vitamin D protects from cancer but sunscreen prevents production of it. Tanning is a self defence mechanism against excessive UV absorption
> Cooking meat in high temperatures creates carcinogenic compounds
> helicobacter pylori is a virus that is carcinogenic
> Skin peeling off after sunburn is a normal process that helps prevent skin cancer, by killing the cells that have had the dna modified. But then I wonder what happens when applying aloe vera gel, is it just that the cells killing response (apoptosis) is not initiated or is it that the DNA is repaired?
> If the genes that causes Brest cancer are activated in 50-80% cases, what do other that do not get it activated do differently?
> Mold produces cancer
> Tomatoes grapes and garlic have anti cancer properties
> Hpv infection is usually cleared by the immune system and does not affect a person’s health, but chronic infection over years causes cancer. The majority of hpv infections will be transient with a clearance time of 6-18 months.
> The chemicals from sunscreen are cancer producing (photosentisized carcinogen)
> Vitamin D protects from cancer but sunscreen prevents production of it. Tanning is a self defence mechanism against excessive UV absorption
> Cooking meat in high temperatures creates carcinogenic compounds
> helicobacter pylori is a virus that is carcinogenic
> Skin peeling off after sunburn is a normal process that helps prevent skin cancer, by killing the cells that have had the dna modified. But then I wonder what happens when applying aloe vera gel, is it just that the cells killing response (apoptosis) is not initiated or is it that the DNA is repaired?
> If the genes that causes Brest cancer are activated in 50-80% cases, what do other that do not get it activated do differently?
> Mold produces cancer
> Tomatoes grapes and garlic have anti cancer properties
> Hpv infection is usually cleared by the immune system and does not affect a person’s health, but chronic infection over years causes cancer. The majority of hpv infections will be transient with a clearance time of 6-18 months.
January 28, 2022
I read the 5th edition that just came out in 2021. It was a well-structured textbook with clear writing, easy to understand figures, and thoughtful call-out boxes. It does not go into significant detail but it does lay a good foundation for additional advanced study. The book could probably benefit from an abbreviations list. Overall, good textbook.
May 30, 2020
Great textbook
April 30, 2019
I referred to this book to complete an essay on cancer metastasis and it was very helpful. All the knowledge of cancer is perfectly summarised and presented in a very user-friendly manner. I would definitely recommend this book for people looking to learn more about cancer.
Displaying 1 - 4 of 4 reviews