In italics are items I've sourced from the book.
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|- 4.5 billion years ago: Earth formed
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|- 4 billion years ago
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|- 3.5 billion years ago: Anaerobic bacteria first appeared around now. AGE OF BACTERIA COMMENCES
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|- 3.2 billion years ago: photosynthetic bacteria first appear
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|- 3 billion years ago
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|- 2 billion years ago
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|- 1 billion years ago
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|- 500 million years ago: Cambrian explosion.
|- 400 million years ago: mass extinction somewhere in here
|- 300 million years ago: oh another mass extinction event somewhere in here
|- 200 million years ago: yep, another one. Dinosaurs first appear.
|- 100 million years ago
|= Now. Somewhere between the last point and here we've had dinosaurs die, mammals rise, a few ice ages, man appeared 300,000 years ago. AGE OF BACTERIA CONTINUES
For comparison, let's take the same number of increments (but make them decades) and start from the year 1550. The following information in italics comes from the book at hand, with direct quotations where indicated.
|- 1550
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|- 1600
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|- 1650
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|- 1670: In 1676 the first bacteria observed under magnifying lens
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|- 1700
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|- 1750
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|- 1800
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|- 1850
|- 1860: The publishing in 1861 Pasteur's theory of disease.
|- 1870: Theory of germs broadly accepted as bacteria being pathogenic.
|- 1880: 1881 Koch's postulates form a framework for determining whether singular bacterial types cause a given infection. 1885 E coli discovered.
|- 1890: bacterial infection most common cause of premature death
|- 1900
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|- 1920: In 1929 Alexander Fleming published findings that a fungus, Penicillium notatum, has antibacterial properties.
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|- 1940: A man was first treated with penicillin in 1941. Much research into naturally occurring antibiotics, most were toxic to humans.
|- 1950
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|- 1970: By about now, all naturally occurring antibiotics that have ever been discovered were already identified.
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|- 2000
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|- 2020: Gaining antibiotic resistant strains of bacteria, particularly in hospitals. The author suggests we will need to modify safety standards for acceptable antibiotic use. "While there is no shortage of antibacterial compounds, the vast majority of them would fail current safety standards," he says, noting that, in contrast, chemotherapy patients are effectively given toxic agents, so perhaps we will need to accept this for bacterial infections in future. Bacteria are good at spreading around their genes, and thus antibiotic resistance is shared. "During the first forty years of antibiotic use, resistance was a problem but not sufficient to force the removal of individual antibiotics from clinical use. Multi-resistance emerged as a major problem in the 1980s with MRSA and was quickly followed by other bacteria that became resistant to most antibiotics. At that time, a greater demand was being made on antibiotics; previously they had primarily been used to treat acute infections that were finally resolved by the patient’s immune system. The era of transplantation and aggressive cancer treatments causing neutropenia has meant that antibiotics have been used in patients with suppressed immune systems". Antibiotic resistance is gaining, and we've had these so briefly.
While I thoroughly enjoyed most of this book, the final chapter suddenly became incredibly densely technical. It did not seem to fit the rest of the book.