Erudite yet readable for the nonspecialist, and sparkling with wit despite the depressing topic. The aim is to show how anti-Judaism isn't some marginal phenomenon, but a foundational platform of Western (and Islamic) thought. Since St. Paul's epistles, Jews have been cast in the role of "vessels of wrath," into which all of the troubling features of cultural life could be quarantined. And this othering has remained constant, even as those troubling features change in response to new ideological needs.
Thus, for the earliest Christian thinkers, Judaism became synonymous with law and narrow literalism, as opposed to the spiritual freedom of Christianity. When Martin Luther wanted to reintroduce the verbatim biblical text during the Reformation, Jews were cast as interlopers in the biblical story, whose protagonists were actually to be regarded as Christian. When commercial activity became crucial to new European states, parasitic "Jewish" speculation was made to stand against productive Christian economic develoment. And when rationalism became fashionable during the Enlightenment, Judaism putatively became the preserve of unreasonable hatred and fanaticism. Critical thinkers abjectly failed to question their received prejudices about Jews and Judaism, even when the thinkers themselves were of recent Jewish descent: e.g., Spinoza, Marx, Hannah Arendt. Indeed, modern thinkers even mined the pre-Christian past for evidence of Jewish iniquity.
Jews didn't have to be present for this kind of thinking to occur, and when scholars throughout the ages write about Jews, they often mean non-Jews with "Jewish traits". But when Jews were nearby, the prevailing images of Judaism had profound consequences for them. In the background, we can see antisemitism rising alongside anti-Judaism, which culminated in the Holocaust. And Nirenberg sees the post-war discourse as more of the same, with "Israel" replacing "Jew". He is cautious to rule out determinism when considering how trends in thought impact behavior, but he does assert that these trends can smooth the way for particular outcomes while making others harder to imagine.
The dismal synopsis is that negative stereotypes can be highly functional for ideological requirements and we can't always rely upon critical scholars to question them. And this is particularly true for figures of Judaism, which form a major pillar of Western culture.