Got this through my local library via Interlibrary Loan (ILL)
Total cholesterol level is useless.
When chol is in HDL, it’s good.
When it’s in large buoyant LDL particles, it’s neutral
When it’s in VLDL (TG), it’s bad.
And when it’s in small dense LDL particles, it’s disastrous.
Pg 97
What you see as LDL on your cholesterol test results is LDL-C, a calculated estimate, not a true number.
Pattern A LDL is large fluffy harmless LDL particles
Pattern B is the small, dense and potentially dangerous kind.
So if LDL is high, demand a new test running the particle test size.
There’s only 1 thing that causes small LDL particles & that’s carbs.
Pg 98
There isn’t a drug that lowers TG’s well, just diet.
High TGs trigger the production of the small dense lipoprotein particles that cause atherosclerosis
Pg 104
Best indicator of health is triglyceride to HDL ratio.
This number goes hand in hand with number of small LDL particles.
Optimal ratio is 1.0 or lower.
Preferably, TGs should be around 50.
Best way to get that: cut carbs and increase fat
Pg 108
CRP (C-reactive Protein) should also be low. If CRP is <1.0, then it doesn’t matter what the cholesterol levels are bc no inflammation so no cholesterol being deposited as plaque.
High CRP can be caused from smoking, too much EtOH, trans fats & processed carbs, high blood sugar, chemical exposure, high BP, &/or stress
Pg 114
Reduce your cardio-metabolic risk by decreasing your dose of statins gradually while simultaneously changing diet to improve overall health.
Pg 118
Jupiter study showed the very best marker of cardiovascular risk is CRP. (Not cholesterol)
Pg 119
The patient is always the boss, and the doctor is the employee; you have hired them to consult about your health. But you are the final arbiter when it comes to your health.
Pg 127
Let your doctor do thru all the std treatment protocols they need to do to stay in medical compliance, even if that includes them writing you a script for statins. That doesn’t mean you have to fill it! This keeps your doctor out of trouble for not treating your high cholesterol “properly “, thus protecting them legally if something happens to your heart health.
Pg 128
If you have excess sugar in the blood, then the sugar attaches and attacks the LDL and causes something called glycation damage. Proteins in the blood get glycated by excess sugar; this is strongly related to diabetes. When you have diabetes, you have high sugar in the blood and that sugar attack’s the proteins in the blood one of the things that it attack’s is the LDL. Think of a keyhole gummed up with ice, preventing you from getting into your car. Your body can have the same problem. The LDL is gummed up with sugar and it becomes inefficient in delivering its goods to the tissues, so you need more of it to function properly. When LDL gets gummed up with sugar, it can’t get recycled by the liver. So you get these small dense LDL particles that are basically crud. They’re garbage that can’t be gotten rid of. It gets stuck in this form that your body can’t use. That’s why these macrophages come into the plaque and scavenge - to basically sweep this LDL into the cell, clean it up, and send it back out again in HDL. The macrophages are performing a very heroic activity in taking the small dense LDL out of circulation. The LDL provides a service of delivering cholesterol and fats to the tissues. This leaves it as a small dense LDL particle that then gets transported back to the liver to become refurbished and cleaned up. That process gets stuck because of sugar.
Pg 143
There is a segment of the population that has a mysterious reaction to low-carb high-fat diet: their LDL-C, LDL-P, ApoB and total cholesterol spike dramatically. The reason for now is unknown.
Pg 145
Here’s the key ?: if all your other health markers incl most of your lipid markets are ok & you are eating alow-carb high-fat diet diet, are you at greater risk of heart attack because your LDL-P is high? We don’t know, because the studies haven’t been done.
Pg 146
Watchful waiting rather than treating with a statin is the smart thing to do
Also re-eval thyroid labs
Don’t get chol tests during wt loss. Reach goal weight, wait a month, then test
When the body is using its own fat energy storage for fuel, blood chol levels may shift dramatically.
Pg158
Lack of micronutrients like iodine, selenium, zinc or copper can raise cholesterol
Pg 159
the benefits you receive from statin treatment is trivial
for a 60 y.o. male who had had a heart attack, the change of being alive for another 5 years is about 90%. By taking a statin every day, he increases those odds by only 2%
pg 165
Pharmaceutical industry spokespeople would have us believe that the benefits of taking their drugs are far more dramatic. But they're merely pointing out the relative risks, which show a greater percentage of perceived benefit, not absolute risks, which have a far less significant benefit. "The drug companies tell us that we can lower the risk of a heart attack by 20% with statins because of the 2% different in mortality rates. With a statin, it's 8% and without statin treatment it's 10%. But to sue the change in percentage rather than percentage points is incredibly misleading."
pg 163-4
Statin drugs increase the risk of diabetes by 4%, impotence by 20%, and muscle and joint pain by more than 40%.
pg 164
If you're really worried about your high cholesterol, get a CT heart calcium scan. If you don't have any coronary artery calcium, stop worrying!
Ideal LDL-C ranges
People at very high risk of heart disease: <70
High risk of heart disease: <100
Near ideal: 100-129
borderline risk of heart disease: 130-159