This book has three major problems that make it a difficult read and also a bit unnerving:
1) The authors have a bone to pick with certain transhumanist arguments, which generally I don't mind a bit of cat-calling in academic texts is good. The problem is, they never really define what they are against or what is the full range of the arguments/suppositions they are criticizing; so as someone who has been working on transhumanism enabling technologies (artificial organs, cell/material (machine interfaces), biosensors), it completely alienated me as it is attacking stuff that is only articulated in the most "popular" aspects of transhumanism.
2) This brings me to the second point, the book is a barrage of how people "don't get it", how simplistic their understanding of large-scale problems, and how the "Enlightenment" point of view is only the part of the story... Yet, the level of understanding of the technologies that are being developed is so superficial that this egging of others looks weird. You can claim that you do not need to understand the technologies to comment on their large-scale effects; yeah maybe but that would not be a University press book, that would be a newspaper article.
3) There is no structure to what is discussed, at one point it becomes completely random rants on climate change policies. The Level I-III technology is a good descriptive framework but it is repeated so many times without adding any depth to it, that it becomes meaningless too. Also, in my opinion, there is a level 4 also. Just like in science where it is very hard to predict the final stopping position of 20 marbles thrown to the ground from a height, it is possible to estimate the exact position of a giant comet; at the highest scale, some interactions are very obvious(for example at U.N. decision level). So things are not always so complex, you do not need to attack all problems in a reductionist fashion, you can look at the emergent behavior (the intricacies of the activities of my cells vs. predictability of my potential macroscale activities as a human for example).
There is one point I agree though, the transhumanism enabling technologies cannot be used for pushing certain political agendas under the shroud of "advancement"; their potential impacts are unknowable thus any sense of certainty in these whether by the scientists or policymakers will spell disaster. But, where I habit professionally, things are not as "blind-sided" as described, which annoyed me. As it is a 10 years old book, I thought maybe it was like that back then, but no. I was in it for 15 years, and in our community, we always at least think about the consequences of our activities. Applied scientists/technologists do not fit into the stereotypical/bleary-eyed idealist scientists (if that ever had existed in the first place).