Writer William Messner-Loebs and artist Sam Kieth tinker a lot with history, including Greek gods and myths into the titular character's travels across Greece in search of students for his school of Moderation, but it is some darn funny tinkering. The writing is somewhat subtle for your typical comic book (or comics reader), but students of classic civilization, classical history, folklore, and mythology will likely get some laughs out of the representations of philosophers and the gods who poke fun at them.
Particularly amusing characters include the lisping Hades and his feminist wife Persephone; pompous Socrates and sycophantic Plato; and the surprisingly laid-back Aristotle. Other philosophers (and philosophies) make guest appearances, too, as does a very young and wild Alexander the Great, but they're all balanced by Epicurus himself, who tries to teach all of them the beauty of being a Moderate.
Not for everyone, perhaps, but if you enjoy some tongue-in-cheek humor that mocks the self-proclaimed intelligentsia, you'll probably find this to your liking.