The hero of this story is a young lad who has the unusual ability of being able to see and talk to micro organisms.
This ability he finds of great help starting as a fresher at an agricultural college in Japan where his fellow students include an SM dominatrix, his best friend is a goth-loli transvestite and his professor is an expert on fermentation. Many natto making, sake brewing and other bacterium related adventures follow.
This is one of my favorite mangas. But seriously, what is there not to like about a manga with a story like this?