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Pathophysiology: The Biologic Basis for Disease in Adults & Children

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McCance & Huether The Biologic Basis for Disease in Adults
and Children has been the leading pathophysiology textbook since publication of
the first edition in 1989. Key reasons for its success include comprehensive coverage,
complete and separate treatment of paediatric pathophysiology, clear writing, and
numerous illustrations, in full-colour beginning with the third edition. The new, fourth
edition of this authoritative and classic text features extensively revised and
updated content and a greatly enhanced full-colour design and art program.

The book is divided into two parts. Part One presents the general principles of pathophysiology, including cellular structure, injury, and repair; fluids and electrolytes, and acid-base balance; immunity, inflammation, and infection; stress; and oncogenesis. The influence of the environment and the role of genetics in the development of disease are also discussed. Part Two is organized by body system, and for each system it provides an overview of normal anatomy and physiology, alterations of function in adults, and alterations of function in children. The alterations chapters consistently present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease.

· Comprehensive coverage provides unparalleled discussion of general pathophysiology and specific disease processes
· Consistent presentation of each disease includes pathophysiology, clinical manifestations, and evaluation and treatment
· Full-color art and design vividly illustrates the clinical manifestations of disease and disease processes and makes the content more visually appealing to the student
· Pediatric content is presented in 10 separate chapters to provide unequaled coverage of how disease processes specifically affect children
· Aging content is identified with special heads within the adult chapters. All aging content is listed with page numbers on the end sheets
· Nutrition and Disease boxes show evidenced-based links between dietary patterns and disease.
· 'What's New?' boxes highlight the most current research and finding
· Algorithms are used throughout the text to illustrate normal and compensatory physiology and pathophysiology
· Detailed chapter outlines with page numbers begin each chapter to provide easy access to content and overview of topics
· Chapter introductions provide a to the student and a rationale for learning the content about to be presented
· Key terms are boldface in text and listed with page numbers at the end of each chapter for easy reference and chapter review
· Chapter summary reviews, in the form of numbered lists, provide concise synopses of each chapter and serve as a built-in content review

· Approximately 300 new full-colour drawings and photographs illustrate normal anatomy and physiology, disease processes, and clinical manifestations of disease
· Extensive revision of chapter 29 on alterations of cardiovascular function features new content on atherosclerosis, minerals and hypertension, and hormones and heart disease
· An Introduction to Pathophysiologyincluded in the front matter provides an overview to the subject of pathophysiology and explains why it is important
· Unintentional and Intentional Injuries section added to chapter 2 explains how injuries alter cellular and tissue biology

1616 pages, Hardcover

First published January 1, 1990

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About the author

Sue Huether

3 books

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5 stars
176 (39%)
4 stars
130 (29%)
3 stars
88 (19%)
2 stars
26 (5%)
1 star
27 (6%)
Displaying 1 - 17 of 17 reviews
Profile Image for Jann.
157 reviews
February 26, 2017
This text claims it's easy to read. I think that's a pretty subjective assessment. It does not keep things simple or start from an easy place and increase in difficulty. With this book, you have to be completely focused and totally ready to jump in or you will end up reading what you need to read several times to catch it all. That being said, I ended up purchasing it (instead of renting), because I will come back to it time and again throughout nursing school. It's thorough, and I learned a lot, but it was as complex as the subject demands. I won't be using it in the future for quick and easy answers, but instead for thoughtful and in-depth ones. I'm also really glad there's a kindle version available because this book is massive in print.
Profile Image for Alyssa Graham.
45 reviews
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December 14, 2021
Spent more time with this than anyone else the last 4 months. Deservedly adding these 1700 pages to my 2021 book list. Tears were shed.
Profile Image for Heather.
3 reviews1 follower
March 24, 2008
Okay, so I had to read this book for my class this semester, but I really like it. I am just nerdy that way. It explains the disease process on so many different diseases in a way I can understand it. It will really enable me to help my patients.
Profile Image for Maria.
67 reviews
November 8, 2025
A brutal first semester for my Master of Nursing degree made this book my best friend. The text is OK, but I've read others that read easier. The website wasn't very helpful with it's "extras." But if all goes according to plan, I'll get a "B" in the class. :)
Profile Image for Dee.
38 reviews
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December 18, 2021
Filled with an amazing amount of information but as all text book, dry as the Sahara. My instructor truly made us read the entire 17 lb book, then tested us on minutiae. That will forever make me hate even a glimpse of this book.
Profile Image for Michael.
20 reviews
December 28, 2009
Read 4th edition. Fantastic book. Great read for a textbook. Great reference.
16 reviews
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March 23, 2012
well i am reading this cover to cover for grad school so there goes my leisure reading this fall! lol
Profile Image for Emily Jaynes.
2 reviews
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December 27, 2012
It does not read very well, and makes relatively simple concepts hard to capture. I have been going back to my undergraduate physiology text often for clarification.
Profile Image for Sophia.
1 review
March 22, 2023
Even utilizing the text bank was an exhausting experience.
Profile Image for Lizzy.
103 reviews1 follower
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May 4, 2019
Doorstop challenge completed.
Displaying 1 - 17 of 17 reviews

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