Hacking gives us a marvelous overview of (primarily) 20th century philosophy of science (though we do have some Bacon, Hume, Comte and Kant thrown in there, among others), focusing on the debate over realism and anti-realism. The first part of the book focuses on trends in the philosophy of science, especially on the 20th century fixation with language, meaning and reference that we inherited from the positivsts, who thought that certain types of sentences, theoretical or observational could eventually be reduced to pure reference, out of which a solid foundation for our knowledge could be built. They eschewed talk of causes as a Humean violation (preferring talk of theoretical regularity as providing the only scientific explanation), were largely anti-realists (since they restricted the real to the observable), and chanted the mantra "against metaphysics!" Hacking does a great job of laying out and contrasting the basic positions of figures like Carnap, Popper, Hempel, and Van Frassen. He also acknowledges the influential (but somewhat less so) strain of thought arising out of American pragmatism via Peirce, Dewey and James. Hacking is perhaps more of an intellectual descendent of these figures, who wanted to substitute method for truth, than the positivists. These pragmatists are more concerned with what we can do with knowledge than the ultimate truth of it (with the exception of Peirce, perhaps). Actually, I wish he'd spent a bit more time with these guys. As Hacking continues, he explains how he wants to get away from understanding science as a theoretical body of knowledge, and also why we might prefer this move in the aftermath of Kuhnian incommensurability (if science is all about making meaningful theories via precise language, then we have a serious problem when a paradigm "shifts" or a new theory takes the place of an old-how can the knowledge be preserved?).
In the second half of the book, Hacking explains that he wants to go back to what he thinks of as a more properly Baconian ideal of experimental science as intervention in the world. Specifically, he suggests that we should count as real what we can use to intervene in the world. He then shows us how our preoccupation with scientific theory over practice has caused us to misunderstand observation, experiment, and measurement, among other scientific activities. For example, we developed an erroneous notion about theory coming either before or after experiment, but in fact they are both too intertwined to be separable. The positivists gave us a legacy of describing observation as "theory-laden" which seems to create a problem for knowledge. Hacking argues that new equipment gives scientists an expanded notion of what counts as observation, and that the use of instruments doesn't necessarily imply that an experiment is fatally theoretical. Importantly, Hacking insists that scientists create and stabilize phenomena. They don't merely uncover or discover them. I really like this notion because there's so much naive talk about science merely unveiling nature, whereas in fact our experiments present nature to us in a very particular, engineered way. Hacking is happy to argue that science is bigger than us, but not so happy to think of that bigness as real, per-se. In fact, Hacking seems to think that some things we observe in science consistently, like the evidence for black holes, aren't actually real, simply because we can't use black holes to make anything or intervene in nature. Once we could, black holes could pass into Hacking's realm of the real. Until then, they will stay nicely categorized alongside ether.
I really liked this book, though I found that, like with many STS classics, its arguments had already thoroughly permeated my cranium. Perhaps the one thing I'm not so sure about here is whether Hacking's set-up really requires us to be realists as opposed to instrumentalists. Perhaps I missed a big point here...I think realism makes the most sense, but the former still doesn't seem to be precluded on philosophical grounds...Otherwise, I highly recommend this book. It's clearly written (a rarity in philosophy!), with a minimum of absurd made-up examples (his examples all come from actual science, which makes a big difference).