Across the Boundaries: Extrapolation in Biology and Social Science

by Daniel Steel

The biological and social sciences often generalize causal conclusions from one context or location to others that may differ in some relevant respects, as is illustrated by inferences from animal models to humans or from a pilot study to a broader population. Inferences like these are known as extrapolations. The question of how and when extrapolation can be legitimate is a fundamental issue for the biological and social sciences that has not received the attention it deserves. In Across the Boundaries , Steel argues that previous accounts of extrapolation are inadequate and proposes a better approach that is able to answer methodological critiques of extrapolation from animal models to humans.

Across the Boundaries develops the thought that knowledge of mechanisms linking cause to effect can serve as a basis for extrapolation. Despite its intuitive appeal, this idea faces several obstacles. Extrapolation is worthwhile only when there are stringent practical or ethical limitations on what can be learned about the target (say, human) population by studying it directly. Meanwhile, the mechanisms approach rests on the idea that extrapolation is justified when mechanisms are the same or similar enough. Yet since mechanisms may differ significantly between model and target, it needs to be explained how the suitability of the model could be established given only very limited information about the target. Moreover, since model and target are rarely alike in all relevant respects, an adequate account of extrapolation must also explain how extrapolation can be legitimate even when some causally relevant differences are present.

Steel explains how his proposal can answer these challenges, illustrates his account with a detailed biological case study, and explores its implications for such traditional philosophy of science topics ceteris paribus laws and reductionism. Finally, he considers whether mechanisms-based extrapolation can work in social science.

Genres: Philosophy, Biology

256 pages, Hardcover

First published January 1, 2007

About the author

Dr. Steel earned his PhD from the Department of History and Philosophy of Science at the University of Pittsburgh in 2002, and is affiliated with the Environmental Science and Policy Program at Michigan State University. His area of research expertise is in the philosophy of science, with particular emphases on causation, confirmation, and implications of these for practical decisions of public policy. He has a strong record of publications in these areas, with over thirty articles, a monograph, and a co-edited reader on the philosophy of social science. His work has appeared in leading journals in the field such as Philosophy of Science, British Journal of Philosophy of Science, Biology and Philosophy, and Philosophy of the Social Sciences. He is the author of, Across the Boundaries: Extrapolation in Biology and Social Science (Oxford University Press 2008). He is also the co-editor, with Francesco Guala, of, The Philosophy of Social Science Reader (Routledge 2011). Dr. Steel's current research focuses on the interaction between values, evidence and decision making in contested environmental issues, such as toxic chemicals regulation and climate change. Some of this work has already been published in a number of articles and more is set to appear in book form in, Phiosophy and the Precautionary Principle: Science, Evidence, and Environmental Policy (under contract with Cambridge University Press).

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