This book “Pragmatic Knowledge with Python Programming” provides a concept of the Python programming language and its practical implementation. This book covers the following Overview of Provides an introduction to Python, its history, and its key features, such as readability, simplicity, and versatility. Setting up Guides readers on how to install Python on their operating system and set up the necessary development environment. Basic Python Programming : Introduces the basic programming of Python, including veriable, datatype and token. Python Flow Explain about the control statement that include variables, data types, operators, control structures (if-else statements, loops), and functions. Input and Explains how to interact with the user by taking input using the input() function and displaying output using the print() function. Python Introduces different data structures in Python, including strings, lists, tuples, and dictionaries. Covers their creation, manipulation, and common operations. Tuples, Lists And Dictionaries : Provides a brief introduction to different data structure of python also explain about the method used. Modules and Explores the use of modules and libraries in Python, showcasing how to import and utilize pre-existing functionality from the Python Standard Library and external libraries. The book serves as an introduction to Python that delve deeper into specific topics, such as advanced language features, web development, data analysis, and more.