Head To Toe is a curious document, one of the handful of novels Joe Orton wrote before his violent death in 1967. None of those novels were published in his lifetime, and it's unclear whether Orton would have wanted this particular book published at all.
As it stands, it fits well with the late 1960's British counterculture, where drug-influenced randomness was incorporated into a number of art forms. Much of that material doesn't stand the test of time, and Head To Toe suffers the same fate. There are individual moments that shine with creative insight, as with this paragraph from the beginning of chapter 5, where the protagonist finds himself imprisoned in a privy:
"And then, he studied how he might liken this house of ordure to the world: first, the pissoirs - they were the mob, gurgle, gurgle, gurgle into infinity. And the lavatory pans were the politicians - there were fewer of them and these came in the same shape and size but not colour. The chains were artists and thinkers - pull one and release a fresh shower of water, cleaning away the shit. Industrialists were toilet paper - some of the cubicles (which he took to be countries) had too much, some hadn't any, in one he had to push his way through festoons of the stuff. These ideas flowered in him; his head almost burst; he did not know where they came from, they were inexhaustible."
But overall, the clever notion of human communities thriving on the living body of a giant (and the hero's exploration thereof) begins to get a bit repetitive. With no plot to speak of, Head To Toe is at times amusing and colorful, but ultimately it doesn't amount to much more than that.