I went into this series, knowing nothing about it, other than that it's a collaboration between Koshi Rikudou (Excel Saga), and Masamune Shirow (Ghost in the Shell)--both series I really like, but in wildly different genres. For me, reading the announcement about Pandora was like hearing Guillermo Del Toro and Jackie Chan would be working together on a project; their styles are so radically different, but man, wouldn't it be interesting to see what they come up with together? So far, in this mash-up of cyberpunk and off-the-wall comedy, the answer is yes.
The story centers around Nene, a cyborg girl with a fully prosthetic body, who's taking a trip to the island of Cenacle, to visit her aunt. En route, Nene draws the attention of an eccentric scientist named Uzal, and gets roped into helping Uzal save the island from a giant robot that her assistants have unwittingly sent on a rampage. Full-body prosthetics are rare, and Nene's body conveniently lends itself to military-style upgrades. (Need expertise in small arms or camouflage? There's quite literally an app for that.)
Things aren't incredibly deep as of yet, but it's an entertaining enough story, thanks to Rikudou's lively artwork (when he doesn't revert to chibi-fying everything), and Shirow's genuinely funny writing. Pandora is unabashedly fan-servicy at times (particularly in how Nene acquires her special abilities from Uzal's assistant, Clarion), but it's all very tongue-in-cheek, and fairly lighthearted.
Pandora in the Crimson Shell is fluff, but so far, it's entertaining fluff. Reading it brings to mind a slightly more pervy version of Slayers, but in a futuristic setting: it's silly, the characters are fun, and there's enough action in amidst the slapstick to keep things moving at a good pace. Time will tell if the charm has staying power, but right now, this is a fun little series.