Autoimmunity Unlocked: 5 Keys to Transform Microbiome, Immune, and Digestive Health and Reclaim Your Life. A 5R+ Holistic Guide for Rheumatoid Arthritis, Lupus, and Crohn's

by Anar R Guliyev

Your body is an ecosystem. To heal immune cells, you must repair their entire environment.

Autoimmunity Unlocked is your complete guide to the 5R+ System—a revolutionary approach to addressing chronic immune diseases by focusing on and treating the human microbiome and body as an interconnected ecosystem.

This book is an encyclopedia of healthy living centered on the immune system, microbiome, and digestive health. Designed for readers of all backgrounds—regardless of medical expertise—yet comprehensive in scope, it simplifies complex functional medicine concepts into practical and actionable steps to holistic health.

Perfect for those managing:

Autoimmune conditions: Rheumatoid arthritis, lupus, IBD (inflammatory bowel disease) and Crohn's disease, Graves' and Hashimoto's thyroiditis, Sjögren's syndrome, multiple sclerosis, psoriasis and psoriatic arthritis, scleroderma, systemic vasculitis, etc.
Digestive issues: IBS (irritable bowel syndrome), SIBO/SIFO (small intestinal bacterial overgrowth, and small intestinal fungal overgrowth), chronic constipation, diarrhea, or bloating.
Allergies and food sensitivities.
Chronic inflammation.
Weak immunity and susceptibility to infections.
Or anyone seeking to improve immune and digestive health holistically.

The core disease factors addressed (DILL+):

Dysbiosis: Disrupted microbiome distribution and composition.
Inflammation: Including hidden intestinal inflammation.
Leaky gut: Compromised health of the intestinal epithelial lining.
Lazy gut: Poor tone and motility of the digestive tract.

+ More topics covered:

Hormonal health
Environment, climate, and microclimate
Hygiene paradox
Sleep and circadian rhythms
Oral health
Physical exercises
Hydrotherapy
Anti-inflammatory diets
Natural remedies
Polyphenols
Prebiotics and probiotics
Fasting
Detoxification
Liver and stomach health
And more…

Over 6% of Americans are diagnosed with autoimmune diseases, and another 6% are expected to develop one during their lifetime. 30% of the population suffers from allergies or food intolerances, and 25% experience irritable bowel syndrome, indigestion, or related issues. Many are also more susceptible to infections and face an increased risk of cancer—examples of the far-reaching effects of immune and microbiome-related disorders.

That's why the 5R+ System is relevant for everyone seeking better health and longevity. It offers a blueprint for a healthy lifestyle and natural healing treatments, designed to restore harmony to your immune system, digestive functions, and the trillions of bacteria in your body.

Inside this book and its online addendum:

5 Strategies.
59 Tactics.
17 Diagrams.
15 Tables.
20 Illustrations.
9 Video Guides, including 6 targeted exercise routines.
100+ Lists, Algorithms, and Tips.
10+ Recipes for naturally fermented probiotic foods.
220+ Foods ranked by their impact on the gut-microbiome-immune ecosystem (5 Food Baskets Guide).
700+ References to scientific research publications.
Numerous endorsements by leading experts—renowned clinicians and researchers worldwide.

Genres: Health

392 pages, Kindle Edition

Published January 27, 2025

Reviews

[Puneet Parashar]

I didn't like it. I really don't understand what bro was trying to do while writing this book. Several QR codes and almost every second-third page mentions to watch a video or photo. It would be better to create a YouTube video with this information instead of writing a book.

[Amy]

This book was f*$#@ng annoying.

It's a huge disorganized mess.

Every chapter is only like, a page and half long.

There are all these QR codes on every other page - I don't read with my phone in my lap, okay? That sounds like hell.

There are all these acronyms everywhere, and since I skimmed around reading it to find useful things it took me forever to finally find out what DILL was supposed to be referring to.

Suggestions are often extremely vague, with no evidence, and no details on the amount of a supplement it might be helpful to take, etc.

Most of this is old news to me, as I've been navigating chronic pain and mystery symptoms and food allergies/intolerances since OHS and Covid 5 years ago.

However, for someone new to this, there might be something useful to learn, IF (you're suffering so much that) you're finally willing to change the way you eat to heal your rheumatoid arthritis or other autoimmune chronic illness.... What I DID take note of (many of these points I'd heard before but needed a reminder of) and what will maybe be useful to me now was:

-avoid chilled drinks: it increases stomach dumping which leads to incomplete digestions and decreased digestive juice production

-improve stomach acid production by eating bitter vegetables, vinegar, fermented pickles; can try dandelion, hops, gentian

-maintain glutathione: sulfur rich food, pineapple, papaya, asparagus, okra, Brazil nuts, spinach, cilantro, turmeric

-HALF YOUR DIET SHOULD BE RAW VEGETABLES, FRUITS, NUTS & SEEDS

-chew more. wayyyyy more.

-maybe beef's not good. or coconut oil.

-avoid snacking: this gives your gut epithelium and stomach a chance to repair themselves, and your liver can get a rest. This is one reason leaky gut and malabsorption are so prevalent today.

-"Don't fear the sensation of hunger; embrace it." (p. 247)

-contrast showers (2-3 min hot, then 30 sec cold)

-capillary circulation/dead bug exercise: increases lymph drainage and blood flow in legs. Lay on back with arms and legs in the air; relax body while shaking/vibrating limbs intensely for several minutes.

(Those are just the points that I myself (after years' experience navigating health problems by myself because doctors don't give a $#!*) need to really try harder to put into practice in my own life - but if you're someone for whom these ideas are brand new, there might be much more you could get from the book, like about not eating SUGAR ANYMORE!!!! Or pork or much meat at all, or moldy cheeses like brie and camembert, or gluten or grains or processed crap; not eating foods that cause any sort of intolerance or reaction, etc.)

[Jodie Cary]

Wow! Just Wow! What a book to read! This book was well written, easy to read and follow, I learnt a lot about how to help myself in Healing my immune and digestive system. There is so much great, helpful information in this book, I loved it! Immune System, Dysbiosis, the Microbiome, Healing an ecosystem, Healthy Digestion, Inflammation, Food Reactions, Supplements, Absorbtion, Leaky Gut, Lazy Gut, Hormones, Exercise, Sleep, and so much more!
I definitely recommend this book to anyone who wants to learn about what is going on inside your body and help to heal yourself.

I received a free copy of this book via Booksprout and am voluntarily leaving a review.

[Agarza]

I’ve read many health books, but this one stands out. It doesn’t just focus on diet—it takes a comprehensive look at how different lifestyle factors shape long-term health. The sections on gut health and immune function were particularly fascinating, breaking down complex science into easy-to-understand concepts. I came away with a much deeper understanding of how to support my body for long-term vitality. If you’re interested in living a healthier, longer life, this book is a fantastic resource.

[Asami Shirinova]

Autoimmunity from a new perspective

The book is a great read for anyone interested in maintaining healthy lifestyle and covers more than autoimmunity. It dives into the nutrition and metabolism and offer many priceless advises on how to maintain your health. Very refreshing.

[D.]

There is so much information and detail in this book. I learned a lot in the first reading and I want to go back to read it a few more times so I don't miss anything. This is a great resource.

I received a free copy of this book via Booksprout and am voluntarily leaving a review.

[R. Hollis]

In depth

As a visual learner, I really appreciate the charts! And the bonuses are really good, but what pushes it into awesome is the info about exercises and gut health! The section about water and laxatives are also informative.

[Dia Sv]

A life altering book. Just started reading it and applying the knowledge to my daily life.