This is the prequel series to "The Incal", the series Jodorowsky did back in the 1980's about a private detective named John DiFool in a surrealistic far future who gets caught up in the quest for a holy relic with 2 matching halves (a white and a black one) that everyone in the universe wants from rivalling galactic empires over religious sects to revolutionary political movements.
At any rate the prequel charts the beginning of John DiFool's career as a private detective in the planetville where he lives. So there is less focus on the space opera and religious mysticism, more on exploring the society of the Pit City as it's called as he gets caught up in all types of intrigue between different squabbling upper class families and ideological factions within its corrupt and dysfunctional surveillance state. His key to this being a rebellious young heiress named Louz de Garra, whose loyalties are never quite clear, but she ends up as something different than a classic femme fatale, and becomes one of the most interesting characters Jodorowsky has written in his comics in a long while to the point she is an integral part of why I enjoyed reading "Before the Incal" so much.
As you can guess, this feels more like a futuristic take on old fashioned detective novels than either the original "Incal" or the concluding sequel series "The Final Incal". (where Louz de Garra, now a space pirate, returns as an important character) Zoran Janjetov's art style fits that as well, since it's less psychedelic than Moebius' and less in line with modern science-fiction trends than that of José Ladrönn who illustrated "The Final Incal", instead feeling like an updated take on "neon noir" crime thriller films of the 1980's.
That said, there are still mystical elements here that can be expected from Jodorowsky. For example, after JDF loses his parents he ends up raised by a secretive new religious movement that preaches to the downtrodden of society while being persecuted by the authorities, and Jodorowsky goes into great detail about its beliefs and observances - a clear callback to his 1989 film "Santa Sangre". (and those observances revolve in large part around a specific rare hallucinogenic plant) JDF also goes through several mentor figures that he has to break with at some point, and each of them requires him to adapt to a completely different worldview and lifestyle - shades of the Masters in "El Topo" but also the different Sephiroth in the Kabbalah. More notably, his nonfiction book "The Spiritual Journey of Alejandro Jodorowsky" goes into detail about how his own life story involved learning from several mentor figures whose life philosophies were radically different from one another.
The final echo of "El Topo" is how "Before the Incal" ends: JDF's crusade together with Louz de Garra to expose a terrible secret incriminating the entire aristocracy of the Pit City and its power structure turns out to be all for naught, just like both of El Topo's quests he undergoes. Yet, as El Topo's son goes on with his life as a monk, so does JDF go onwards to his career as a detective into his next assignment which we see being set up here. Which turns out to have much bigger stakes for the entire universe, not just the Pit City. I think there is an important point in all this, as well as the fact of Louz de Garra returning in "The Final Incal" to play a central role in its final cosmic drama with infinitely more important implications than she did here.