Why Brains Need Friends: The Neuroscience of Social Connection

by Ben Rein

"An exquisite book that reminds us our minds aren't soloists but symphony we are wired for connection."—David Eagleman, PhD, author of Incognito and Livewired

A neuroscientist’s guide to boosting your brain health by living a more connected life, and thriving in a post-interaction world

Headlines have made clear that we are in a crisis of loneliness, but the conversation has yet to explore how spending less time with others can impact the body and mind on a cellular level—and why this knowledge is part of the way forward. Renowned neuroscientist Dr. Ben Rein dives into the fascinating science of social interaction, revealing how our brains are wired for connection and why modern life is challenging those ancient instincts. Through the lens of neuroscience, he explains our need for community and provides new frameworks for bringing togetherness into our lives. Rein uncovers the mesmerizing biological factors at play in our moments together, from small talk with baristas to deep conversation with friends, and shares how to leverage this information to our advantage as we seek happiness and health.

Enlightening and empowering, this book
How socializing supports brain health and moodThe hidden dangers of isolation and why it increases the risk of death by any causeWhy the brain experiences virtual conversations differently from in-person encountersThe science of likability and the secrets of making a positive impressionThe neuroscience of empathy, deep bonds, and how we understand othersHow relationships with animals can support our healthHow certain drugs like ecstasy enhance social exchanges, while others like painkillers impair themStrategies for improving your social life to maximize benefits to your mental and physical health
Weaving together cutting-edge scientific discoveries, storytelling, and practical advice inspired by data, Rein reveals how our brains and our bodies are made stronger by connection, and ultimately why brain health is critical to our well-being.

Genres: Psychology, Science, Nonfiction, Self Help, Health, Neuroscience, Audiobook

254 pages, Kindle Edition

Published October 14, 2025

Reviews

[Jchotey · Rating 1 out of 5]

Dr. Rein’s core message in this book is that healthy brains need social interaction. He does a good enough job going into some of the research and nuance behind that message, like why virtual interactions don’t suffice, the role of empathy, etc. It’s easily accessible for someone who isn’t well-versed in neuroscience.

But the book is painfully overwritten. It’s obvious that the author had a page count to meet: Some sections are annoyingly repetitive; there are laughably unnecessary illustrations throughout the book just to fill space; and there’s just so much pointless filler.

I also hated the tone and writing style. Dr. Rein takes on this BuzzFeed, millennial, infantilizing, quirky tone that I just find nauseating. Like, “Yes, you read that right—I used compassion and zebra fish in the same sentence.” Something to this effect is at the end of every other paragraph.

Lots of really shallow moralizing throughout the book too, about how the concepts in the book could help heal humanity. “This is how we put the human back in humanity.” Give me a break.

[Ashley Singer · Rating 1 out of 5]

I agree with this review from Amazon. Books like this are dangerous when in the hands of narcissistic people who use these as guides on how to better where a mask, love bomb, and manipulative others into seeing a false version of themselves. They do the same with psychological terms by weaponizing and using them out of context. They learn how to interact without understanding the reasons and heart behind these interactions. Similar to how many religious organizations teach people how to obey/interact without helping them develop personal discernment which guides their interactions.

As an autistic person who was recently abused by a narcissistic person (who is currently reading this book) I fear for those in relationship with her. Someone who has to read about why a brain needs friends (not to mention the whole person) is someone who doesn’t naturally experience or understand this. If you have to learn how to make a good first impression, you aren’t being your authentic self. You are lying to others and yourself.

I have a few emotionally deep relationships built on vulnerability, respect, trust, accountability, conflict repair, compassion, empathy, understanding and love. I’ve learned through experience that quality is far better than quantity (which the abuser only appears to have). The person who abused me claimed she didn’t do surface relationships. In the end she didn’t have the capacity for deep friendship. She couldn’t connect emotionally. She’d get defensive, project, or go silent. So she reads books like this to learn. Until someone develops the ability to self reflect, take accountability, and show empathy, they will never develop authentically deep relationships. Someone can be surrounded by surface relationships, appear happy, yet feel lonely. While someone who is physically alone may experience solitude and peace. This book reinforces ideals our capitalist society encourages like ableism and narcissism.

“Mark F.
2.0 out of 5 stars
Verified Purchase
The book extolls neurotypicals and extraverts
Reviewed in the United States on October 15, 2025
Format: Hardcover
This is a very idiosyncratic critique, based on my personal reasons for buying the book, but may be important for others to know. Carl Jung reputedly said, "Loneliness does not come form having no people around you, but from being unable to communicate the things which seem important to you." This book's thesis misses Jung's point.

That's because the book is slanted toward extraverted neurotypicals; introversion is misidentified as shyness, and neurodivergents are overlooked, except to say mice "regained empathy" when given MDMA or through an alternative manual stimulation technique (183). This implies the old ableist trope: that autistics lack empathy and need to be cured. Not true at all. It also implies autistics and even introverted neurotypicals should aspire to be extraverted neurotypicals and to be surrounded by people. I have no such aspiration; my AuDHD is not a disorder nor a flaw, it is a difference in design, and doesn't need to be fixed. Maybe the mice felt the same way.”

[Jen Brodehl · Rating 4 out of 5]

3.5 Stars- I always love learning more about the brain and this book had some interesting information.

[Victoria Godi · Rating 5 out of 5]

First book of 2026. 5 out of 5 stars 🌟 read. This is specially important starting a new year with intentions.

First love that this book is written by Ben, who is a sci-communicator, who I even followed back when I used to use TikTok. He is very book good at breaking down brain concepts into something anyone can digest.

I love brain related books since I worked on brain myself during my PhD. This book highlights the importance of social interactions and how it can improve our quality of life. Definitely will be working on socializing more in 2026, with friends, family, and forming better connections with my students.

[Susan · Rating 3 out of 5]

I was underwhelmed by this book for a number of reasons. He makes a lot of generalizations and most of what he has to say isn't new to me. Also, as an older neurodivergent extreme introvert with social anxiety I felt personally not addressed.

[Claire Kopp · Rating 5 out of 5]

Excellent book on the importance of making and keeping friendships, especially later in life. Written by neuroscientist Ben Rein, this book delves into the science of WHY human social connection is so important.

Copied from Amazon, - a good summary :-)
=====================================================
Enlightening and empowering, this book reveals:

How socializing supports brain health and mood
The hidden dangers of isolation and why it increases the risk of death by any cause
Why the brain experiences virtual conversations differently from in-person encounters
The science of likability and the secrets of making a positive impression
The neuroscience of empathy, deep bonds, and how we understand others
How relationships with animals can support our health
How certain drugs like ecstasy enhance social exchanges, while others like painkillers impair them
Strategies for improving your social life to maximize benefits to your mental and physical health
Weaving together cutting-edge scientific discoveries, storytelling, and practical advice inspired by data, Rein reveals how our brains and our bodies are made stronger by connection, and ultimately why brain health is critical to our well-being.
=================================================

I listened to the audio of this book and learned so much. I am fortunate to have many friends and many connections. This book emphasized how important face to face (ie coffee/ lunch, etc.) meetings are. I will try harder to nurture these friendships! Real conversations with friends and family are the best way to do this.

I listened to the audio of this book but will order the hard copy to have as a reference.

A must read!

[Josh · Rating 3 out of 5]

Why Brains Need Friends is built on a fascinating and timely premise, but it ultimately struggles under the weight of its own academic flexing. When the author's expertise serves the narrative, it’s genuinely brilliant. The standout example for me was the exploration of canine companions—specifically the biological "why" behind why dogs might actually hold more neuro-social value for us than cats. Moments like that, where a complex concept is perfectly integrated to explain a universal human bond, are where the book truly shines.

Unfortunately, these moments of elegant storytelling are often buried under an avalanche of academic noise. Despite the attempt to make neuroscience accessible, the text suffers from a flood of Greek and Latin verbiage that often feels like a performance of intellectual bona fides rather than a source of real insight. This constant need to showcase terminology disrupts the narrative flow and keeps the reader at arm's length, turning what should be an immersive journey into more of a dry lecture.

I also found the tone to be a significant hurdle. The writing style leans into a "BuzzFeed-esque," quirky millennial voice that feels a bit infantilizing, creating a strange cognitive dissonance between dense medical terminology and "Yes, you read that right!" filler. Furthermore, the book’s thesis feels like a "one-size-fits-all" approach that extols the virtues of extroverted connection while largely missing the nuance of introversion.

Ultimately, if you are willing to sift through the shallow moralizing and the stylistic quirks, there is value to be found here. But if you’re looking for deep, original insight that doesn't require wading through an unnecessary amount of "scientific noise," you should probably look elsewhere.

[Tom Morton · Rating 4 out of 5]

"Interacting with a diverse group of people is associated with the greatest affects on well-being, so you may be better served by hanging out with a few different people than by spending all of your time with one person."

"Of all the amazing things humans can do with our remarkable brains, arguing online is probably one of the most useless ones...online arguments generate more negative emotions than in-person disputes and are less likely to result in consensus. You're really not getting anywhere. Ignore the trolls and avoid becoming one yourself."

There is a lot of fascinating and useful info packed in this book about how important meaningful socialization is for our mental health and well-being. Definitely worth the read!

[Suzanne Smith · Rating 4 out of 5]

4.5 stars

[Mari Sim · Rating 5 out of 5]

Great book to start the year with!
While listening to it, I caught myself being more mindful about my social life and starting more conversations with strangers (and I enjoyed them a lot!)

[Zibby Owens · Rating 5 out of 5]

Based on years of research, this book reveals how friendship, empathy, and social bonds literally shape our brains. These connections influence everything from stress and memory to immune function and happiness. The author presents complex neuroscience with clarity and humor, illustrating how our need for social interaction is hardwired into our nervous system. He explains how oxytocin fosters trust and how loneliness can change brain chemistry, making science feel both deeply human and surprisingly hopeful.

The author explains complex neuroscience in an engaging, accessible manner, sharing insights into how even small, everyday interactions can enhance mental health, creativity, and a sense of belonging. The stories and studies he shares—about cooperation, community, and the impact of small acts of kindness on the brain—transform abstract research into practical, inspiring insights. By the end, you not only understand the importance of connection, but you feel it.

To listen to my interview with the author, go to my podcast at:
https://shows.acast.com/moms-dont-hav...

[Ehsan · Rating 5 out of 5]

Hi there! I’m Ehsan 😎
Here’s my review after reading The Social Brain and checking out some of the harsh, negative critiques 📚

1. About the book:
The entry point to the world Ben Ryan (the author) created and the way he shares his research and insights is genuinely fascinating 🤩. Perfect for anyone curious about human interaction and connection! That’s why I bought this book—but it went far beyond my expectations 😲.
It revolves around neuroscience 🧠 and social interactions in a super simple way, yet it throws in ideas that totally shocked me. I literally shouted, “WTF!” at some points.
So yes, it’s about neuroscience and social behavior—but don’t underestimate it! This book is also about love ❤️, compassion, and humanity.

2. Writing style and the author:
No exaggeration—some parts made me laugh out loud 😂. Ben drops funny, relatable moments even in serious scientific discussions, making the concepts easier to understand while keeping you entertained.
It’s not a novel, but the storytelling—especially his anecdotes—is super engaging 📖. I found myself standing up, pacing around, just blown away 🤪.
Not too childish, not too formal—perfect for readers of almost any age.

3. Accuracy of content:
I care a lot about whether information is correct ✔️. Whenever I doubted something, I double-checked and was satisfied 👍. The author also lists sources at the end of each chapter 📚. The content is simplified for easier understanding, but it’s still accurate.

4. About critics:
A: Some readers didn’t enjoy the style and tone 🤷‍♂️. If you prefer dense, ultra-formal scientific books, this might not be for you. The storytelling style is similar to Nir Eyal and Tony Robbins: fun examples, acceptable humor, no weird jargon.
B: Some complained the book talks too much about social interactions 🤔. That’s fair—most of the book focuses on interaction, love, and humanity, not deep introversion. If you’re looking for in-depth introversion insights, other books are better. The main focus here is human nature and our evolution from tribal living 🌱.

5. Who should read it?
If you’re curious about the brain and want to understand relationships better 🧠, but hate getting lost in heavy scientific terms, this book is a delicious, digestible treat. After reading a heavy book, this one felt like a refreshing, tasty snack 🥰.

Hope this helps! 🌟
With love from Iran 🇮🇷, and تمام پارسی زبانان☕
Ehsan Golmakani

[Doug R · Rating 5 out of 5]

Examples from life and science make a case for self-improvement
Dr. Rein asserts that social interaction is a key element of a healthy brain, and a satisfying life. Then he goes on to make that case in so many compelling ways. Educational, yet heart-warming. Using comparisons to common things, Dr. Rein introduces us to neuroscience concepts, and how they influence our connections to the world. His writing style is very conversational and engaging, like sitting and chatting with a friend. He pulls from our collective experience and his own life to give relatable examples. Then, he goes on to cite many interesting published studies in easily digestible terms. And, while many studies come from renowned journals, he includes a myriad of examples from his own personal research, and that of his trusted peers. You'll understand the world, and yourself, in a new way.

[Jennifer · Rating 4 out of 5]

First, I would like to say I was shocked with how many times I laughed, and some of his jokes were just kind of funny
Secondly, I am pleased with how the book developed. I was worried it was gonna be very too dimensional and focused on extroverts and very quasi normal people however it seemed to dive into just about every little aspect that I was hoping it would obviously there were some things definitely left out that I think should’ve been focused on more.
I will say, I am incredibly validated and feel vindicated by the research on romantic relationships and their importance in our brains. And I will continue to stand on my soapbox and tell people about that until the cows come home anyways I would recommend he almost lost all of his stars at one point and I almost gave him no stars, and he slowly started to earn them back as the book went on

[Chris M. · Rating 5 out of 5]

This is a book that anyone can benefit from reading. This book is also helpful if you work in people-facing roles. Ben Rein discusses the importance of social connection through the lens of neuroscience, but he is able to break down a lot of advanced graduate level neuroscience concepts in a way that is accessible to everyone (not an easy task). One of his main points is that division and isolation are harmful to our brains, and he presents a lot of evidence explaining the reasons why, which is very helpful in an age where person to person interactions are on the decline. Although he doesn't speculate too much about the future, he does share enough evidence to prove that online interactions are not a substitute for human connection.

[kglibrarian (Karin Greenberg) · Rating 5 out of 5]

A fascinating look at the way the brain works in relation to social connections. The writing is accessible and conversational, making some of the most intricate brain processes easy to understand. He uses personal anecdotes and experiences from his own professional studies to enhance the research findings.

There are chapters about social media, drugs, empathy, and dogs (yes, I was pleasantly surprised by this one!). In each section, Rein lays out the historical context for his ideas and then goes on to show the implications for modern society's impact on age-old brain structures.

It's a book filled with interesting information that will have me looking differently about all of my social interactions, both physically and digitally.

[Javad Usefabadi · Rating 4 out of 5]

«مغز رفیق باز» کتابی است درباره ی ارزش و اهمیت تعاملات اجتماعی و تاثیر آن بر مغز انسان.
کتاب جالب و خواندنی ای است.
تمام کتاب رو دوست داشتم بخش هاییش رو بیشتر:
مثلاً فصلی که درباره‌ی تعاملات در فضای مجازی بود خیلی برام کمک کننده بود یا بخش تعامل با حیوانات و فصلی که درباره‌ی تاثیر دارو ها بر مغز بود و بخش خجالتی نباشید.
اگر تعاملات اجتماعی برای شما صرفا یک سرگرمی است این کتاب به شما میگه که مغز ذاتا اجتماعی طراحی شده و تعامل اجتماعی رو برای بقای خودش لازم داره.
اگر دنیای عصب شناسی براتون جالبه و روابط اجتماعی براتون مهم. این کتاب برای شماست.
کتاب اندکی ایراد ویرایشی داره.

[Kat · Rating 5 out of 5]

THIS BOOK!!!!!!!!!!! What a beautiful and important message packed full of education & delivered in an easily digestible (& sometimes pretty funny!) format. Dr Ben Rein starts off by stating he wants science to be accessible to all and he makes good on that sentiment with every! single! page! Given that my research interests focus on social function, I recognize my own biases but to me, this is the book of the year. It’s certainly the best book ive read in a long time.

[Sammie g · Rating 5 out of 5]

This is arguably one of the best and most important books I’ll ever read. Ours brains are miraculous and even more miraculous when we connect w those around us.

Also I was so impressed with Ben’s ability to elucidate his research on neuroscience in digestible doses. This book felt like I was getting smarter in the easiest way possible. Well done Ben!!!!!!!

[S Ahilan · Rating 5 out of 5]

Very easy to read and understand.Dr Ben explains interesting researches done with rats.I learned the importance of social interaction and how loneliness affects our health.Serotonin is very important chemical for us.Dr Ben also explains how psychedelics like Ecstasy and Psilocybin may help us become more empathetic and connected.Overall,a very interesting book.

[Brenna Goodman · Rating 5 out of 5]

Not the dogs and Bubbys at the end! Definitely a relatable and more importantly readable evidence based book on the science of loneliness. “When you feel like yelling at someone you don’t know, turn and hug someone you love”

[Salvador Aceves · Rating 5 out of 5]

Delivers powerful insights in every chapter. It effectively explains the neuroscience behind why empathy is not just altruism, but a vital cognitive tool, and how being surrounded by friends is a key ingredient for better physical and mental health.

[Reader · Rating 5 out of 5]

Telling everyone to read this book! So cool to be able to learn about ourselves and why we interact the way we do. Definitely recommend!

[Lyn C. · Rating 5 out of 5]

I am planning on teaching a high school level course using this book as a key text. I loved it!
It's incredibly approachable, much like Dr Rein's social media identity.

[Jeff · Rating 5 out of 5]

Loved this book. Fascinating, interesting and I am going to for sure take a lot of the ideas to heart as I strive to improve my relationships and social fitness

Highly recommend

[Stephanie Paley · Rating 5 out of 5]

Love it! Psychology meets fascinating neuroscience. He goes into nuance of empathy, introversion vs extroversion, the love for our fur babies and oxytocin pathways. Plus more. It’s a quick read

[Emma · Rating 5 out of 5]

Brilliant! So wholesome 💗

[Maris · Rating 4 out of 5]

Interesting and fun. I think about anyone would benefit from this quick read in this day and age.

[Evan · Rating 3 out of 5]

Pretty good, first chapter is best and is essential for overall wellbeing, the rest is all over the place and not necessarily related to topic.

[Kristen · Rating 4 out of 5]

4.5 for me. Quick, engaging read with lots of accessible, fun science about human (and animal) connection.