Weightless: A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve

by Rocio Salas-Whalen

NATIONAL BESTSELLER • A board-certified physician shares her must-have guide to using GLP-1 medications, such as Ozempic, Wegovy, Mounjaro, and Zepbound, to reverse obesity and take charge of your health, with established strategies for maximizing your results

“This book is a game-changer. Dr. Salas-Whalen gives you the science and the compassion this conversation has been missing. You are not alone anymore.”—Mel Robbins, #1 New York Times bestselling author of The Let Them Theory

Whether your struggle to lose weight has lasted years or started more recently, GLP-1 medications will help you finally end it. While GLP-1s have redefined how we treat obesity, the search for expert care is likely to leave you feeling confused, overwhelmed, and unheard. Misconceptions are everywhere. Many doctors are still catching up with the science. And you may find a prescription but not the medical supervision you need for the best results.

In Weightless, Dr. Rocio Salas-Whalen, an expert in obesity medicine, delivers the real-world strategies that have helped thousands of patients achieve health goals that once felt out of reach. Her deeply compassionate approach sees obesity, not as a personal failure but as a chronic health condition that deserves medical treatment. Drawing on years of clinical expertise and the lived experience of her patients, she explains how

Rethink what you know about weight management: Learn why “eat less, move more” is an outdated and ineffective prescription.Give your GLP-1 journey a strong Choose an experienced provider, ask the right questions at every appointment, and get better outcomes if you’re using telehealth.Preserve muscle for long-term Follow Dr. Salas-Whalen’s advice for increasing protein intake and optimizing your strength training.Protect your Manage side effects with evidence-based care, recognize when you need a dosage change, and know what to do when GLP-1s don’t work.Adjust to life after Navigate the unexpected physical, social, and psychological changes that accompany significant weight loss.
Comprehensive and empowering, Weightless offers judgment-free support that ensures you never feel alone on this journey.

Genres: Nonfiction, Health, Self Help, Medical, Science, Audiobook, Diets

271 pages, Kindle Edition

Published December 30, 2025

Reviews

[Kristina P (ARC Reviewer) · Rating 5 out of 5]

PUBLISH DATE: December 30, 2025
Weightless (A Doctor’s Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve) by Rocio Salas-Whalen, MD is an outstanding and incredibly helpful resource for both patients and healthcare providers.

This book is extremely well written and, most importantly, written for the patient. It walks readers through GLP-1 medications in a clear, approachable way, answering many of the questions people actually have. It explains the different types of medications, how they work, insurance coverage considerations, FDA approval, and much more without feeling overwhelming or overly technical.

The second half of the book focuses on what a sustainable lifestyle can look like alongside a GLP-1 medication. It discusses the importance of eating enough protein, how to determine individual protein needs, and includes practical examples of what a week of eating might look like while working toward protein goals.

I also appreciated the way this book reframes obesity. It clearly explains that obesity is not simply a lack of willpower, but is influenced by hormones, genetics, and other biological factors, all supported by research. This perspective feels compassionate, empowering, and validating.

Additionally, the author does an excellent job covering side effects, contraindications, and how to have productive conversations with your healthcare provider, from the very first appointment through ongoing follow-ups. It equips readers with the language and confidence to advocate for themselves.

I highly recommend this book and fully expect to read it again.

Author Rocio Salas-Whalen, MD is a triple board-certified endocrinologist and obesity medicine specialist who founded New York Endocrinology, a practice focused on personalized care for endocrine disorders like diabetes, thyroid disease, and menopause, with a special expertise in weight management using GLP-1 medications. She is known for integrating innovative treatments, authoring the book Weightless, and providing comprehensive care for conditions such as PCOS, pituitary disorders, and adrenal disorders.

I received a complimentary digital ARC [Advanced Reader copy] of this book via NetGalley. Thank you to the Publisher and the Author for the opportunity to read and review this title prior to publication. As always, the opinions expressed in this review are my own.

BOOK TITLE: Weightless (A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve)
AUTHOR: Rocio Salas-Whalen, MD
PUBLISHER: Rodale Books
FORMAT: ebook
PAGES: 288

[Bethany (Beautifully Bookish Bethany) · Rating 4 out of 5]

A practical, medically grounded, and compassionate guide to GLP-1 medications, perfect for anyone beginning to consider the possibility of using one, though it may not offer a lot of new info for those who have already done a great deal of reading and research. That said, Weightless traces the (longer than most people realize!) history of these medications, how they work, what to expect on one, and the importance of prioritizing weight training and a diet high in protein and fiber.

I really appreciate that it also gets into the mental and emotional impact of weight loss and body changes, and often not positive ones. I don't think have enough conversations about what its like to realize because something about you has changed physically just how fatphobic the world around us is. I also appreciate how she talks about who should actually be using these medications, what they can treat, and the importance of close medical supervision and taking things slowly. If you or someone you love is taking or considering taking a GLP-1, this is worth picking up. I received a copy of this book for review from the publisher. All opinions are my own.

[Melody · Rating 5 out of 5]

4.5 stars. I was able to access an ARC of this book at the perfect time for me, and am very grateful to have had the opportunity to read it. Dr. Salas-Whalen does an excellent job of balancing education about glp-1 medications, compassion for the struggles of patients who are battling obesity and all of the stigma and emotions that often come with that, and practical information on how to navigate diet and other life changes that may occur as patients use these medications. As a therapist, I particularly appreciated the attention given to the emotional impact of living with obesity, making changes and dealing with maintaining that change. I am also intrigued by suggestions for possible new applications of these drugs, for example in working in the field of addictions .And as a person who has spent way too long battling my weight who recently (and with much anxiety) started on a glp-1 medication, I appreciate the compassionate tone and hopeful voice that she brings to this area, and the easily understandable breakdown of medical information. I will definitely be mentioning it to my doctor. Thanks to Netgalley for the ARC!

[Rachel · Rating 5 out of 5]

This book is a must read for anyone who has been obese and is scared to consider GLP-1s. Dr. Salas-Whalen offers a very well researched (with all the resources listed at the end—much appreciated for someone who likes to review journal articles) book on GLP-1 drugs. It includes the history of the drug (much further back than you would expect) along with tips and advice on who could benefit, how to talk to you doctor or find a doctor to prescribe them, all the different drug options, and what to expect when using the drug. The book is easy to read and understand for anyone, not just those with medical knowledge. The content that really makes this book stand out is that Dr. Salas-Whalen makes sure to teach you how to use a GLP-1 with proper nutrition and strength training. This is what so many miss when on a GLP-1 that leads to increased side effects and poor outcomes. Even if you never decide to take a GLP-1, this book offers great information that will really open your mind to obesity and how medications can lead to a healthier population without stigma in the future.
Thank you to Netgalley, the publisher, and the author for an ARC in exchange for my honest opinion.

[Zach Strassburger · Rating 1 out of 5]

I was not a fan of this book. I had to finish it because I read it through the goodreads program and have to review it, but I found it to be pretty dull. I think it’s one of those books people might read a chapter or two out of but rarely straight through.
I was very annoyed at the book for not having footnotes but it turned out it had endnotes and they just weren’t set up in the advance reader copy. Oops. So that should be fine for everybody else.
I wanted to learn more about glp1s but maybe not this much. My apologies to the author. The book tries to be less dry by having short patient stories but they weren’t long enough to actually care about the person.
I also felt weird that the author didn’t include anything negative about glp1s. She’s an advocate.

I received a free ecopy from the publisher and NetGalley in exchange for my honest review.

[Corinne’s Chapter Chatter · Rating 5 out of 5]

A must-read for anyone on, or even considering, a GLP-1!

I don’t usually reach for nonfiction in the medical sphere, but because this topic is personally relevant to me, I decided to give it a shot (no pun intended)—and I’m so glad I did. This book is incredibly well written, approachable, and impressively thorough. I ended up reading it in a single sitting. While I already knew a fair amount going in, there was just as much that was new to me, and the author explains everything clearly without ever talking down to the reader.

One of the highlights for me was the inclusion of personal stories. They’re varied, relatable, and help ground the science in real human experience. You can tell the doctor behind this book genuinely cares about both the subject matter and his patients. That level of compassion and practicality is something I wish we saw more often in healthcare.

The book does an excellent job dispelling common myths and misinformation surrounding GLP-1 medications. It also gives smart, actionable tips on how to optimize results, outlines what doesn’t work, and dives into both aftercare and what the future of these medications might look like. It feels comprehensive without being overwhelming.

Truly, whether you think you already know everything about GLP-1s or you’re just beginning to explore the idea, this is absolutely worth the read.

I fortunate to receive a complimentary eARC from Rodale Books via NetGalley, which gave me the opportunity to share my voluntary thoughts.

How I Rate
Because I mostly read ARCs, I focus on how I think fellow readers with similar tastes will respond. I sometimes round up or down based on pacing, prose, or overall impact, and I try to keep my personal preferences from weighing too heavily.

⭐️ 1 Star – Finished, but not for me as it has way too many issues; I never DNF ARCs but would have had it not been one.
⭐️⭐️ 2 Stars – Struggled due to writing, content, or editing issues.
⭐️⭐️⭐️ 3 Stars – Decent read with untapped potential; recommend with some reservations.
⭐️⭐️⭐️⭐️ 4 Stars – Really enjoyed it and would recommend for several reasons.
⭐️⭐️⭐️⭐️⭐️ 5 Stars – Exceptional; lingers in my mind well after reading. A story I’d gladly revisit.

[Mary · Rating 5 out of 5]

This book clearly and without any judgement explains the huge importance of GLP-1 in the field of obesity. Even though I’ve read numerous medical articles concerning this topic, I learned so much more. I was hoping though that there would be some information relating to how this type of medication that diabetics have used for a few years could also help them to understand how weight is not their fault either. There’s still the prejudice of doctors that if you have diabetes that it is your fault. This field of endocrinology as it pertains to weight loss should incorporate both sides of this issue instead of separating them. It’s good there are separate medications for both now, which was an extremely necessary step as seen from the lack of enough medicine produced in relationship to the overwhelming number of prescriptions written in 2023. I as a diabetic could not get my prescription filled at this time and had a 8 month lag. That in turn resulted in my A1c rising and weight increased. The medical field is making huge inroads in weight loss but so much more needs to (and will) be done.
I received this ebook from NetGalley for free and am voluntarily leaving my review.

[Deborah Awalt · Rating 5 out of 5]

I can’t recommend this book highly enough. The book is written by a board-certified endocrinologist and expert in obesity medicine who draws on years of clinical experience and the lived experiences of her patients. If you are thinking about starting on a GLP1 or know someone who is taking GLP1, this book gives you incredible insight into the medication. Eat less, exercise more doesn’t necessarily work for everyone because there are biological, hormonal and genetic factors at play. The book makes clear that a person with overweight or obesity has a chronic health condition (not a behavioral issue) that deserves medical treatment. GLP1’s are not just an easy way out. We treat depression, high blood pressure, high cholesterol…we should be treating overweight and obesity as well.

[Lori Hughes · Rating 5 out of 5]

This book has changed my life. 🥹

[January · Rating 5 out of 5]

Weightless: A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve by Rocio Salas-Whalen, MD (2025)
7h 17m narrated by Rocio Salas-Whalen, MD, Allyson Ryan, and Graham Halstead, 288 pages

Genre: Nonfiction, Health, Medical, Self-Help, Mental Health, Science, Health & Fitness, Endocrinology, Diet & Nutrition, Weight Management

Rating as a movie: PG-13

Featuring: Disclaimer - This book is not a substitute for medical advice from a physician; Foreword by Mary Claire Haver, MD; Rethinking Obesity: What We Got Wrong, Understanding Obesity, The Real Cause of Excess Fat Tissue, Testimonials, The Factors Behind Obesity and Excess Weight - Genes and Epigenetic Changes, Your Hormones [Insulin Resistance, Hypothyroidism, Perimenopause and Menopause, Pregnancy and Postpartum Weight Retention, Polycystic Ovarian Syndrome, Cushing’s Syndrome/Disease], Your Environment, Aging and Metabolic Changes [Metabolic Slowdown, Muscle Loss (Sarcopenia), Medications], Lifestyle Factors; Diagnosing Overweight and Obesity, The Problem With BMI, Enter GLP-1s: A New Era of Weight Management, History of GLP-1s, How They Work, FDA vs Compounded, Mild Side Effects, FAQ - Frequently Asked Questions, Are GLP-1s Right for You?: Evaluating Your Candidacy and Risks, Types of Weight Stories, Eligibility, Medical Conditions, Life Stage - Children, Young Adults, Older Adults, Age, Hormones, The Road Starts Here: Finding the Right Provider and Getting Your Prescription, Endocrinology, Obesity Medicine, Family Medicine, Red Flags, Med Spas, Telehealth, Your First Visit, When Your Provider is Nit the Right Fit For You, Which GLP-1 Is Right For You, What You Can Do at Home, Navigating the Costs, Navigating Insurance Coverage, Reducing the Risks of Compounded Pharmaceuticals, Your Life-Changing Journey Begins, Your GLP-1 Journey: What to Expect, Setting The Right Goals, Body Recomposition, What To Expect With Each Drug, Choosing and Changing Your Injection Day, Best Injection Techniques, Medication Storage, Traveling With Medications, Follow-up Appointments, Body Composition Analysis, Tracking Progress, Staying on Course: Your GPS for Progress, Lifestyle Changes, Protein Consumption, Strength Training, Titration and Troubleshooting: Adjusting Your Dose and Navigating Side Effects, Side Effects and Solutions, Life After GLP-1s, Maintaining Your Weight: Strategies for Sustained Success, Food Marketing, Behavioral Changes, After the Transformation: Facing Yourself and the World, Physical, Emotional and Psychological Adjustments, Ozempic Face, Therapy, Negative Comments, Quick Scripts, for Social Situations, Protein Cheat Sheet, First Appointment Checklist, Follow-up Appointment Checklist, Acknowledgments, Notes, Index

Books and Authors mentioned: The New Menopause: Navigating Your Path Through Hormonal Change with Purpose, Power, and Facts by Mary Claire Haver MD; The Galveston Diet: The Doctor-Developed, Patient-Proven Plan to Burn Fat and Tame Your Hormonal Symptoms by Mary Claire Haver, MD;

My rating: 🌟🌟🌟🌟🌟👩🏼‍⚕️🩺💉🧪⚗️👨‍🔬

My thoughts: 📱15% 1:07:03 Chapter 2: Enter GLP-1s: A New Era of Weight Management - This is certainly going to take me all week these chapters are long but the accent is slowing me down. I feel like I should've gotten the print but I don't have time to wait for it As I need this information as soon as possible and it's not unbearable it just has to go slow. So far the information is fantastic along with her approach.
📱36% 2:37:47 Chapter 4: The Road Starts Here: Finding the Right Provider and Getting Your Prescription - I have gotten accustomed to the accent so I was about to get to 2.55, but 2 is more comfortable. There is a lot of good information here. I like how she breaks it down but I feel like she could say more on some of these topics. This was published before oral medications were approved, and I had no idea they were being prescribed to children.

I was told this book is really good, and it is really good. This is the third book I have read on this topic, if memory serves right, and it is definitely the best book so far and it really gives profound information that should be standard knowledge among physicians and patients as part of this treatment plan.

Recommend to others: Yes! Everyone thinking about this treatment should read this book.

Memorable Quotes: This is an apology letter to anyone who has struggled with weight. Whether you’ve carried the burden of obesity your entire life, fought constantly to lose those last ten or twenty pounds, cycled through endless diets, or battled persistent food thoughts, I’m writing this book for you. And the first thing I want to do is apologize on behalf of the medical community. For too long, we approached chronic conditions such as obesity as “willpower problems” or moral failings. We sent patients home with oversimplified advice about “calories in, calories out,” and when the numbers on their scales didn’t go down, we chalked it up to noncompliance. We treated the symptoms but did nothing to treat the disease because we didn’t fully understand it as a medical condition. In the process, we caused our patients struggling with obesity and weight loss to become intensely distrustful of healthcare providers.

As one of the few endocrinologists in the world who has been specializing in obesity medicine since the advent of GLP-1 treatment, I’ve listened to the testimonials of thousands of patients. I have a unique body of knowledge, and I want to disseminate this information to as many people as possible. There aren’t enough experienced doctors, but hopefully, with this book, there will be well-informed patients.

Throughout this book, you’ll notice that I use person-first language when referring to people with obesity or related health conditions. That means you’ll see phrases such as “a patient with obesity” instead of “an obese patient” and “a person with overweight” instead of “an overweight person.” This isn’t just a matter of semantics. It’s very important to me always to frame obesity as a medical condition, never as a personal failing or defining trait. Language matters, and how we talk about health can shape how we think about it. When we put the person before the diagnosis, we’re not blaming the patient; we’re reinforcing a core belief of this book: You are not your weight.

For decades, medical professionals have been taught to approach obesity as a simple math problem: Eat less, exercise more. This advice was repeated in exam rooms, public health campaigns, and weight loss programs. And because it was presented as a straightforward solution, it also carried an unspoken assumption: If a patient wasn’t losing weight, it must have been due to a lack of effort, discipline, or willpower. But if this approach truly worked, why did obesity rates continue to rise? Why do millions of people—many of whom have followed every diet, exercise plan, and medical recommendation—still find themselves struggling with their weight? The answer: It’s not because patients aren’t trying but because this approach to treating obesity is fundamentally flawed.

When a patient who had overweight or obesity would tell us that they followed the recommendations but did not lose weight, we did the worst thing possible: We didn’t believe them. If after several appointments the patient’s weight seemed static or even increased, then either the doctor or the patient, sometimes both of them, would come to see that lack of progress as an impossible hurdle to overcome—and simply stop talking about it. We would instead turn to treating the symptoms of obesity because, for them, we did have medications that provided results. In the medical community, conventional wisdom told us that that was the best we could do. It wasn’t until I started seeing patients with obesity five days a week, eight hours a day, that I finally learned something new—something that defied what I’d been taught in medical school: Our patients were listening to us. Not only did they obviously understand the simple “calories in, calories out” formula, but they were following it—and going above and beyond. They counted calories, cut carbs, avoided fats, and exercised relentlessly. They’d tried it all: fasting, juice cleanses, Atkins, keto, paleo, SlimFast, Weight Watchers. (A Google search will show you that there are hundreds of weight loss diets out there, and these patients are more familiar with them than anyone else.) They’d exhausted exercise programs and trainers. Some had spent thousands of dollars on so-called fat camps with only temporary success. This happened for both people who had struggled with weight for their entire lives and those who had experienced weight gain after hitting a certain age or a certain life event (such as pregnancy, menopause, or illness). Even for the people who drastically transformed their habits, their results were not the expected ones and were nonlasting. Our patients were doing exactly what we told them to do. But the weight wouldn’t come off, no matter what they did. When they’d report this back to us, we’d tell them again: Eat even less. Move even more. Try harder. It’s no surprise that patients who struggle to manage their weight grow to dislike doctors. And you know what? I can’t blame them. We, the medical community, had failed them, and we had some things to change.

Obesity was recognized as a disease in 1948 by the World Health Organization (WHO)—but it wasn’t until 2013 that the American Medical Association (AMA) formally classified it as a chronic, multifactorial disease. This may sound like a minor distinction, but it reflected a major shift in medical understanding—one that forced us doctors to rethink the way we approached its treatment.

The Industrialized Food System: Engineered for Overconsumption It’s nearly impossible to walk into a grocery store, gas station, or even pharmacy without encountering shelves of highly processed, hyperpalatable foods. These foods are filled with refined sugars, saturated fats, and artificial additives—and they’re designed to override your natural hunger and fullness signals, leading to overeating and weight gain. Ultraprocessed foods now make up more than 50 percent of the average American’s diet. These foods are intentionally addictive, triggering the release of dopamine in our brain, making us crave more. The food industry spends billions of dollars on marketing each year to encourage their consumption, often targeting children and vulnerable populations. Big Agriculture and the food industry profit from a population hooked on calorie-dense, nutritionally poor foods. Much like the way the tobacco industry downplayed the risks of smoking for decades, food corporations have strategically marketed processed foods while dismissing their direct role in the obesity epidemic.

[Randal White · Rating 5 out of 5]

One of the most helpful, informative books that I have read all year! I admit it, due to several personal injuries, health issues, and just plain laziness, I found myself quite a bit overweight. I've tried all kinds of diets, all kinds of exercises, and really not succeeded to the point I was satisfied. Then along came the "miracle drugs" of GLP-1 medications. I watched the television ads where all these celebrities have had incredible weight loss while using the drugs. I was bombarded with social media ads offering reduced rate subscriptions to the medication. And I have had friends that have lost a great deal of weight while on the drugs.
Somehow, I was still hesitant (chicken) to ask my doctor about the medication. I am old enough to remember when "Fen-Fen" was the supposed miracle weight loss drug. And what happened to the hearts of people who took it.
Then, in my annual visit with my cardiologist, he recommended Zepbound to me. Said he had been on it for six months and felt better than ever. I literally trust that man with my life, as he has already saved it once. So off I went to my primary care doctor to inquire about getting a prescription. "Sure, no problem" was the response. A short explanation of what to do, and out the door I went. That's the problem with today's medical industry, the poor doctor's are so rushed that they are only allowed a 15 minute visit with the patient. Hardly enough time to discuss all of the ramifications of the medication, and what to expect.
Still, I began the medication, and it has worked immensely! I'm down 35 pounds, with another 15 to hopefully lose. I was still left with a lingering uncertainty, of what was happening, what was the reasons, and what else was available.
AND THEN CAME ALONG THIS BOOK! I'm so happy that I was granted an ARC from NetGalley. I read the entire book the next day, and then again two days later. It is one of the most informative books that I have ever read.
The author is fortunate enough to be able to run a private medical practice, where she has the time and patience to thoroughly explain the who, what, where and how of how GLP-1 drugs work. Oh, how I wish I could find a doctor like her! So she had done the next best thing, and written down the information she shares with her patients. Clearly, informatively, and no fluff or fillers. Easily understood, it's as if she were sitting next to you explaining everything you wanted to know.
Thanks to this book, I am now very, very confident in my weight loss journey. I know exactly what's happening, and what to expect in both the short term and long term. AND...what is coming next in the GLP-1 medications, and how exciting the new batch will be!
It's not often that I can say that a book has physically and mentally changed my life for the better, but in this case, it definitely has!
Get this book and start living your life again!

[Cindy Spear · Rating 5 out of 5]

The subtitle describes this book exactly: A Doctor’s Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve. She discusses the various weight loss medications such as Ozempic, Wegovy, Mounjaro, and Zepbound and their effects on the body and how used properly can be life savers for those who desperately need them. But not without proper guidance, care and maintenance. Which is what she offers in this information packed book.

Although I have read a number of health books due to a strong interest in self-care, I don’t usually choose to review them. This one, though, caught my attention on Netgalley as there has been a fair bit of discussion about weight loss medications. And although I have no experience with them personally, I do know people who do and thought if this was a good book I could recommend it to them. Little did I realise how much this manual covers and how fascinating I would find its contents.

Weightless begins with an interesting Forward from a colleague who cracks open the truth about obesity: that it has been misunderstood and mistreated. She states that ‘Weightless reframes obesity as the chronic, complex condition it truly is—not a willpower problem but a medical one.’

Author Dr. Rocio Salas-Whalen then begins with an Introduction that is very humbling and powerful by issuing first an apology on behalf of the medical community ‘to anyone who has struggled with weight’. To see such accountability is inspiring. For years patients have been sent home with ‘oversimplified advice’. Drs treated the symptoms (often unsuccessfully) without treating the disease. They ‘did not fully understand it as a medical condition’. But today weight management is seen in a new and positive light thanks to ‘increased aid, research and treatment.’ Although this is great news, the rapid adoption of new drug therapies are being administered without proper training and advice. As Dr Rocio Salas-Whalen states ‘although GLP-1s are revolutionary, they’re just one piece of the complex puzzle.’ She wrote this book to put all the factors together so it works. It includes nutritional and mental health support, too. This comprehensive health journey provides a firm foundation and redefines obesity from being a personal failing or defining trait— to confirming the medical condition it is. And to remove the blame and stigma attached to it in the past.

The book is then broken into Part I, II and III.

Part I - The Road Ahead: Rethinking obesity, Enter GLP-1, Are GLP-1’s Right for you. The Road Starts here. (Within these sections are honest discussions, evaluations and how to find the right provider to assist you on your journey.)

Part II – Your Life Changing Journey Begins: Your GLP-1 Journey and what to expect, Staying on Course: Your GPS for progress, Titration and Troubleshooting

Part III: Life After GLP-1s: Maintaining your weight: strategies for Sustained Success, After the Transformation: Facing Yourself and the World.

This powerful and informative guide delivers the information to patients and their friends and families in a very readable form. Dr. Rocio Salas-Whalen explains the history, misinformation, terminology and how these drugs work and what tools you need to be successful in their use. There are food Cheat Sheets, appointment Checklists and a wealth of excellent advice to those who could really appreciate it. I found that although the guide expands our knowledge of the treatment of weight issues, it covers so much more. Why is obesity a bigger problem today than in the past? The obvious reasons such as less physical activity and more processed foods to consume are mentioned. But also how our radically altered environment has affected us, too. As a result, there have been some subtle changes in our body chemistry. Chemicals in and on foods and those genetically modified surely have added fuel to the fires of destruction. And even when the body manages at some level to adapt or deal with all these negative things, there are still consequences. One area that I found fascinating is how our ancestors’ living conditions changed their DNA. This in turn has been passed down to us in the current age. I actually never thought extensively before about this aspect of our make-up but it certainly makes sense. Those who lived through various famines and the Great Depression, etc. were not only affected psychologically but also at deep physiological levels which we have reaped today. As distressing as that can be, the wonder of it all is how our bodies have tried to adapt and continue to do so if given proper tools. Proper nutrition, vitamins, exercise and appropriate medicines can assist with the healing process. Yes, the extent of the long term damage must be noted but it is encouraging to know people still stand a fighting chance.

It is obvious from reading this book that Dr. Rocio Salas-Whalen MD board-certified endocrinologist, obesity medicine specialist is passionate about helping those who need it. ‘Weightless’ definitely provides a bounty of ‘science, clarity and confidence’ to explore weight loss options. I totally recommend this eye-opening, compassionate and empowering guidebook to doctors and patients (current and upcoming) alike. It certainly delivers an uplifting and positive path to wellness and will surely help those who need answers and guidance. 5 Stars ⭐️⭐️⭐️⭐️⭐️

Thanks to Rodale Books and Netgalley for a review copy.

[Cindy (BKind2Books) · Rating 5 out of 5]

4.5 / 5 stars

GLP-1's have seemingly come out of nowhere to take center stage on the discussions of dieting and weight loss. While they actually date from the early 2000s, it is only since the formulations became more user-friendly - weekly vs daily / twice daily injections - and the indications were expanded to other conditions besides type 2 diabetes that their use has exploded. This book traces the history and research into these meds as well as how they are best used and how to handle common side effects and problems with tolerability. The book was written by a board-certified endocrinologist and weight loss specialist. She is compassionate and does not talk down to her audience. Overweight and obesity are multifactorial problems and the use of these meds are not crutches or the 'easy' way. There is still much work that her patients do to be successful - increasing protein intake to avoid muscle loss, working out (especially strength training) to build muscle. If you are taking these meds, or just considering them, it worth a read to get the best out of this emerging therapy.

[Vanessa Valenzuela · Rating 4 out of 5]

Glp1 medications were a very trendy topic in 2025. As someone who has struggled with their weight after having a baby, (and had very poor self image and eating issues before the baby) these medications seemed like they were marketing to my demographic. I spoke to my doctor about it early last year. She knew nothing about it, and only prescribed Wegovy to a handful of people. So I decided not to go along with it because I was uninformed at the time. I had no idea of the processes and what it actually did.

‘Weightless’ walks you through the whole journey of the glp1 discoveries and FDA approvals. Then it tells you all you need to know about being on a glp1 injection. From the prescription process, to the injection, to the side effects, and the after hitting your goal weight. It also provided protein guidelines and tips to healthy weight loss.

After reading this book, I feel much more in the know about Glp1’s and I do suggest reading it if you’re at all interested in learning about these medications. I wont be going on one any time soon, but it’s good to know options!

Thank you Net Gallery for the opportunity to read this!

[Ty Maynard · Rating 4 out of 5]

I think this is a really great guide for people who are considering GLP-1 medications. The author is a board certified doctor with a specialty in obesity medicine and endocrinology. She's not only extremely educated on these types of medications, she's also very empathetic and understanding towards those who may seek out these medications in order to help with Weight-loss.

The book is an easy read, informative and well written. Each process a patient might be met with is described in detail, from the moment they first speak with their doctor- to the day to day after taking the medication. The book speaks lots about the glamification and lack of knowledge that many health care providers have when dealing with these drugs, and which kind of questions you should consider when choosing a physician.

Even as someone who's not actively considering these medications I found this to be an interesting read, it taught me lots about the human body even beyond the scope of GLP-1 medications. I would like to thank the author for the compassion she has for her patients and I would like to thank NetGalley for providing me with access to this ARC.

[Tabitha Zangre · Rating 5 out of 5]

I recently the made the difficult decision to start Zepbound and I am so glad I read this book to help me along this new path to health. I have struggled with disordered eating and the effects of the roller coaster that is dieting on physical and mental health. For the last several years, I have embraced intuitive eating and a Health at any size framework. Unfortunately, I never did achieve a healthy body image nor is MY body healthy at this size although I know that people certainly can be healthy in large bodies and unhealthy in small ones. I am undertaking this journey with all the learning I have had, not discarding it and this book is incredibly helpful at both reframing your thinking and offering a practical guide along the way.

[Stephanie · Rating 5 out of 5]

Highly, highly recommend this book to any health care providers with patients taking or interested in GLP1 medications. Such a concise and comprehensive overview of what these medications are and what patients can expect to experience while taking them.

Weightless is a love letter from Dr. Salas-Whalen to her patients, and I hope everyone taking GLP1s has a provider like her, but if you don't, read this book! Dr. Salas-Whalen maps out how to get the most out of your medication, addresses possible side effects and how to prevent or manage them, and offers options for long-term weight management in a way that is empathetic and easy to understand.

[Helen · Rating 4 out of 5]

I wasn’t expecting much from this book as I suspected that this author might be cashing into the hype around weight loss jabs but I was really pleasantly surprised. It was well written, considered and sensible and covered all the elements of the journey, including psychological adjustments you need to make. I am not taking the medication but I found there were also interesting tips in there for everyone. I think this would be a really good read for anyone thinking about it. Thanks to NetGalley and Rodale Books for the ARC.

[Tanya · Rating 4 out of 5]

Very informative

[Ann Warren · Rating 4 out of 5]

Very practical and informational book on use of GLP1 medications in managing obesity. I appreciate the author’s compassionate approach and acknowledgement that obesity is a chronic, multifactorial medical condition… not a moral failure. My mom passed away from an obesity related cancer and failed to seek medical help for years because of the stigma her weight carried with her doctors. I only wish she had access to these new medications that give so many hope for overcoming obesity and its related complications. Good read for those wanting to understand more about GLP1 treatments. {Audible}

[Becky Gallego · Rating 3 out of 5]

Not really any new mind blowing information.

[Suzanne Crane · Rating 5 out of 5]

This is a must read for anyone who has battled with their weight, particularly those who are taking or considering taking a GLP-1 medication to assist with weight loss. I found it to be exceptionally informative. The only thing that would make this book better: get on my radar a year ago instead of a month ago. This book was amazing for my transition from weight loss to maintenance.

[JenBsBooks · Rating 4 out of 5]

Yes ... after years of struggling with my weight and seeing the success others have found with GLP-1 medications, it is something I am trying. I'd already done quite a bit of research, so parts of this book felt a tad tedious, but I thought the focus and explanations of the importance of muscle, protein and strength training, were very informative. Parts were a little too "yeah, I'm so proud of you" and then other parts would cover some things that patients may not be dealing with, things I might have skipped or skimmed if reading, but that's harder to do in audiobook format, which is what I had. Looong waits at the library, so I used Spotify listening hours to get this immediately. 99% of the time I also have the Kindle copy on hand for reference, and I really would have liked to have it, but not enough to pay $14 (and library waits were very long).

Divided into three parts ...
1. The Road Ahead
2. Your Life-Changing Journey Begins
3. Life After GLP-1s

In part 1 ... the chapters were
1. Rethinking Obesity: What We Got Wrong
2. Enter GLP-1s: A New Era of Weight Management
3. Are GLP-1s Right for You? Evaluating Your Candidacy and Risks
4: The Road Starts Here: Finding the Right Provider and Getting Your Prescription

In part 2 ...
5. Your GLP-1 Journey: What To Expect
6. Staying on Course: Your GPS for Progress
7. Titration and Troubleshooting: Adjusting Your Dose and Navigating Side Effects

In part 3 ...
8. Maintaining Your Weight: Strategies for Sustained Success
9. After the Transformation: Facing Yourself and the World

Extras include: Protein Cheat Sheet, First Appointment Checklist, Followup Appointment Checklist

I know with Libby borrows, if there is an "accompanying PDF" I can access it through Overdrive online (which I rarely do, because I almost always have the Kindle copy, which has that non-audio info). I'm not sure how to access it in Spotify.

In the "Rethinking Obesity" ... while I can see some wisdom in considering external factors, I think this was a little too "it's not your fault" ... for some people, it IS, even if there are some of these other items to consider, overeating, sedentary lifestyles are still a thing and there should be SOME responsibility for some obesity issues. I don't let myself off the hook so easily, knowing it's the eating, I can't out cardio my calories (I try!). Hoping this medication will help give me a little extra self-control to fight the cravings (and yes, so far so good!)

The author really pushes finding a good doctor, having many follow-up appointments, getting scans all along the way. She is very disdainful of the companies with a quick telehealth prescription policy ... alas, I must admit I was thrilled with the easy access. I DID discuss it with my PCP, and he was completely on board/was okay with less expensive compounded medication ... but ultimately, rather than making another appointment with my doctor (which would have been $200 out of pocket, toward deductible) I went with one of those telehealth companies (Brello). While of course it would be wonderful if everyone could go to a specialist, try out a few doctors to find a good fit, pay for labs (I did have labs done, indicating that medically I do need some help getting A1C/Cholesterol down), have scans to monitor muscle ... so many of us pay thousands in premiums, that really only cover catastrophic care. All of these appointments would be out of pocket, and just not really feasible.

Of course this author also warns against the compounded medication, even saying it was illegal (a point that is constantly in flux ... it IS allowed now with tweaks) and recommending the "name brand" ... again ... $$$$. Honestly, I didn't even TRY to get this covered by insurance (my PCP said didn't think it would be), not wanting to deal with the wait, paperwork, requirements to try other medications first, set titration schedules. I'm comfortable with a compound, and feel there are several advantages to it (of course not mentioned here).

I really liked the GPS portion, and the information and explanations about protein, and muscle, and felt like this is where I learned the most. Still double checking some of the info ... the author states that GLP-1 users should aim for 100g of protein a day, and that this protein should be spread out, only 30 counting toward that total at any one meal.

The side-effects portion was interesting ... but also extraneous if one is lucky enough NOT to be having any of those symptoms.

The final chapters, for "after" ... feel a little odd, when one is just starting on this journey. Should I read these chapters now, or wait until I have lost the weight? ;) This book covers the ENTIRE journey, but of course people picking up the book will either be just starting, in the middle, or at the end, so portions of the book will not match the reader's moment, unless the reader actually does stop and start again, reading the chapters months apart.

Narrated by the author ... I liked her accent. I usually listen at a 1.5 speed, but did feel I needed to slow this down just a bit (1.25). There were a couple other narrators that stepped in to cover some "stories" (personal experiences from patients) and some of the more factual presentations (leaving the author to narrated the more personal, first person, sections, very conversational).

I really liked the title tie-in ... not only physical weight, but emotional/mental as well.

I would absolutely recommend this for anyone on or considering GLP-1, even if it's a family member not themselves, just to have a better understanding. I would like to have a copy for reference ... the physical copy is ridiculously expensive (maybe cheaper, paperback will be coming?) and I've heard from more than one person that a purchased Kindle copy didn't download correctly. I got the sample (TOC and first few pages).

[Kelsey reviews•books · Rating 5 out of 5]

▹TL;DR Review: As someone who’s been on a GLP-1 for over a year, I found this book to be a great tool for not only reading about maintenance but would have been helpful to read prior to starting my journey. If you or someone you know is thinking about starting a GLP-1 journey, I recommend starting with this and talking with your doctor to see if it’s a good fit for you. ♥

▹My ⭐ Rating: ★★★★.5 out of 5
▹Format: 📱 eReader
Thank you to NetGalley, Rodale Books, and Dr. Rocio Salas-Whalen, MD for an advanced copy of this book in exchange for my review. These opinions are my own.
─────────────────────────

○★○ What to Expect from This Book: ○★○

– About: Focuses on the medically grounded science, practical use, and real-life examples of GLP-1 medications for weight loss and improved health. Reframes obesity and weight management as a chronic health issue vs. a moral or willpower problem. This book is informative for readers who need help with choosing providers, understanding the effects of each medication, what to expect for results and what is expected from the patient both during and after treatment.
– Tropes: self-help, education on GLP-1, compassionate medical navigation, evidence-based strategies
– Representation: for patients who have gone to the doctor and have been told to “lose weight,” I see you. You are not the problem. This book will help reframe obesity and weight management so you can start your healing journey.

─────────────────────────

★○ If You Like the Following, You Might Like This Book ○★

➼ Framing obesity as a chronic condition that isn’t as simple as “willpower”
➼ Good tools to help you start on a GLP-1 journey, if you and your doctor feel like it’s a good fit for you

─────────────────────────

🎯 My Thoughts:

Before sharing my thoughts on this book, I want to offer some brief context so readers understand my perspective:
I’ve lived in a larger body for most of my life and have experienced weight stigma in medical settings, relationships, and everyday life. Like many others, I’ve cycled through countless diets with temporary results. I’ve also been on a GLP-1 medication for about a year and a half, which has significantly changed both my physical health and my relationship with my body.

This background naturally shapes how I approached Weightless, but I believe the book has value regardless of where you currently stand on weight-loss medication.

What stood out most to me is how comprehensive and grounded the book feels. Dr. Salas-Whalen begins by outlining the history and medical purpose of GLP-1 medications, how their use has evolved, and who may benefit from them. She also provides practical guidance on finding knowledgeable providers and navigating care—an aspect that many people struggle with but that’s rarely addressed clearly.

The book goes beyond medication alone, focusing on how to use GLP-1s responsibly and sustainably, including what to expect as you approach maintenance or long-term goals. I appreciated that it doesn’t frame these medications as a quick fix, but rather as one tool within a broader health journey.

Most meaningful to me was the attention given to the emotional and social realities of weight loss and the stigma surrounding these medications. The tone throughout is compassionate, nonjudgmental, and practical. Rather than reinforcing shame, the book reframes obesity through a medical lens and acknowledges how deeply personal and complex these experiences can be. That approach made me feel seen in a way few health books (or doctors) have.

The author also addresses accessibility and cost, openly acknowledging that GLP-1 medications aren’t financially available to everyone. She offers alternative strategies and supportive suggestions for readers who may not be able to pursue this option right now, which felt thoughtful and inclusive.

One area I wished had been explored more:
While the book does touch on the mental and emotional changes that can accompany weight loss, I would have appreciated a deeper discussion of the potential psychological side effects of GLP-1 medications themselves—particularly for individuals with a history of disordered eating. This may be an area where more research is still emerging, but given how closely weight, food, and mental health are intertwined, it felt like an opportunity for further exploration.

Overall, Weightless offers a compassionate, evidence-based perspective that challenges long-standing narratives around weight and health. Whether or not GLP-1s are part of your own journey, this book provides valuable insight into the science, the stigma, and the human experience surrounding them.

Some of my favorite quotes:

╰┈➤ ❝I watched the tension in his shoulders ease as his emotional burden was lifted. He started to cry. For the first time, he heard that he hadn’t failed. He felt the validation that what he was up against wasn’t a personal flaw but a medical condition.❞

(about one of the author’s patients after he came to her for help with his obesity)

╰┈➤ ❝One of the most revolutionary things about GLP-1 medications is that they make weight loss feel more natural. For many people, that means no more crash diets, no more white knuckling through hunger, and no more obsessing over every bite…That’s because they don’t just reduce appetite; they recalibrate the entire system that used to drive overeating in the first place.❞

╰┈➤ ❝Everyone involved needs to understand that this is not cosmetic weight loss; the goal is not simply to “get thin” but to reduce long-term health risks and improve quality of life.❞

[Jim Razinha · Rating 4 out of 5]

I think this books stands alone on this subject in a number of areas, and while that is praise for what it is, it is also an indictment of the system, the status quo, the indifferent medical professionals, body shamers, internet keyboard warriors who have made obesity and weight loss a personal failure. It is, instead, a medical condition, something Dr. Salas-Whalen embraces and, if I may take liberties, evangelize.

My skeptic brain goes into overdrive when I see books that use definitive articles - “The” solution to your problems (one size does not fit all; you have more credibility if you say “a” possible solution is…), exclusive book selling lists - the four quadrants, the ten things you need to do (those usually tie to the definitive articles), or hyperbole - “miracle drug”, “groundbreaking”, “revolutionary”, “the secrets no one tells you”.

That’s not what happens here. Dr. Salas-Whalen is obviously a cheerleader and advocate for the medications she describes here, but she only used the word “revolutionary” four times (and “miracle drug” only once in the Introduction as a side eye to doctors prescribing it without helping patients with the holistic treatment). It’s not the theme, though. Talking the reader through as much as practicable on the subject is the theme. She says:

“I can't tell you how happy I am that you picked up this book. This means that you're on a GLP-1 medication, you are a family member or friend of someone taking one, or you might be considering using one for weight management.”

I am in the middle group - family member (though it is GLP-2, not -1, but the principles of before, during and after are the same). And I requested and received a review copy of this from the publisher through NetGalley to learn more.

Dr. Salas-Whalen establishes from the start that she understands. “Being skinny is not the goal. Losing fat is the goal. Improving your health meaningfully is the goal..” She says,
“Throughout this book, you'll notice that I use person-first language when referring to people with obesity or related health conditions. That means you'll see phrases such as "a patient with obesity" instead of "an obese patient" and "a person with overweight" instead of "an overweight person." This isn't just a matter of semantics. It's very important to me always to frame obesity as a medical condition, never as a personal failing or defining trait. Language matters, and how we talk about health can shape how we think about it. When we put the person before the diagnosis, we're not blaming the patient;…”

This is good. Much like “person with autism”, this is the language we all need to use, and then we all need to understand why it needs to be used.

She had the credentials and the experience and she knows how important is is to talk to, understand, connect with patients. She know “We [doctors] are set up to fail as physicians when we are not given the freedom to practice medicine as we see fit.” Meaning, when an office manager dictates the time allowed, physicians don’t have time to get the big picture… and may be going in a rote (and possibly wrong) direction when it comes to diagnosis and treatment.

This is an easy read. Yes she goes into the science. Yes she talks about studies. And more importantly, she makes the information accessible. From making it clear this is a medical not mental issue, to the background of the medications- history, mechanisms, effects and possible side effects, to what’s happening under the medication, what you need to do while taking it, emphasis on on taking in protein to prevent losing muscle mass with the fat (someone commented that they wished Dr. S-W had focused on protein… I think she did, with constructive repetition to reinforce the importance), dosages, post goal attainment habits. Interspersed with short testimonials, which may bother some with tethering inclusion, while for others they may serve as inspiration or identification - “Hey! That’s me!”

And that this is a medication (I have deliberately not used the term “drug” to not trigger any adverse impression to treat a condition not unlike high cholesterol or blood pressure: it can be safely taken as a maintenance dose for life. And there is no shame in doing so. I have been on statins for decades for my cholesterol. At first I thought my eating habits were at fault, but that didn’t prove to be the case, so… lifetime maintenance without guilt. Neither should there be with taking a GLP-1 medication, and I think Dr. Salas-Whalen has done a good job here conveying that.

And if you’ve read this far, you should so know that the healthy lifestyle promoted here is also good for folks not on one of these medications. Protein, exercise, mindful awareness of body composition… you get it.

[Harley Quinn · Rating 5 out of 5]

4.5★: A NECESSARY REFRAME OF OBESITY, EVEN IF THE SOLUTION IS PRO-GLP1. For decades, patients struggling with their weight were told the same thing: “eat less, move more, try harder, repeat.” Weightless opens by explaining why that advice has failed so many people—and why its persistence has caused real harm.

In the opening section, Dr. Rocio Salas-Whalen reframes obesity with clarity, empathy, and medical rigor in a way I wish were standard across the healthcare system. Her discussion of the six causes of obesity is clear, non-shaming, and deeply humane. Obesity is presented not as a moral failure, but as a complex medical condition shaped by biology, environment, and lived experience.

She identifies the causes as:

1. Genes & Epigenetic Changes — some people are biologically predisposed to gain weight more easily than others, and those tendencies can be amplified by life events and exposures.

2. Hormones — disruptions in hormonal signaling (including insulin, leptin, ghrelin, cortisol, thyroid, and others) can drive weight gain and actively resist weight loss.

3. Your Environment — emotional, social, and physical environments matter, including childhood and generational trauma, chronic stress, modern work patterns, and car-dependent lifestyles that quietly but powerfully promote weight gain.

4. Aging & Metabolic Changes — metabolic shifts over time, including loss of muscle mass and changes in energy expenditure, make weight management harder with age.

5. Medications — many commonly prescribed drugs promote weight gain, often without patients being warned.

6. Lifestyle Factors — dietary patterns, sedentary behavior, chronic stress, alcohol use, and consistently getting less than seven hours of sleep all play meaningful roles.

This framework alone makes the book worth reading.

As the book continues, Dr. Salas-Whalen is unapologetically pro–GLP-1 medications, which she views as potentially life-changing tools. That enthusiasm clearly shapes the book’s center of gravity. However, this is not a “medication replaces everything else” argument. She strongly emphasizes building and preserving muscle mass, higher protein intake, right-sizing eating, and more movement as foundational—whether or not medication is part of the plan. GLP-1s are framed as support, not a substitute.

Even so, the book feels less balanced than it could have been. Risks, limitations, and long-term unknowns are discussed, but generally through a favorable lens rather than a skeptical one.

Where Weightless shines again is in its practical guidance. Dr. Salas-Whalen offers concrete advice on choosing a knowledgeable doctor, what kind of care to look for, how to get started, and what to monitor along the way. As an endocrinologist, her credibility is high, and she convincingly argues that obesity often deserves specialist care, not recycled advice or dismissal.

One of the most unsettling sections covers compounding pharmacies. ☠️ The lack of oversight she describes is genuinely alarming and left me wondering how such practices are permitted in the U.S. healthcare system at all.

Overall, Weightless earns its high rating for empathy, reframing, and medical credibility. I would have welcomed a more critical stance on GLP-1s, but the book succeeds at something arguably more important: dismantling the simplistic “try harder” narrative and treating obesity as the serious, complex medical condition it is.

Published a month ago in December 2025, this book currently has a 4.56-star average by 443 GR peeps.

[MC · Rating 4 out of 5]

Rating: 4.25

Summary: For someone who is considering or just starting to take a GLP-1, or who has a family member who is, this book would be a great foundational guide to use as a handbook through the journey. It was an easy-to-read yet comprehensive book, and the author Dr. Rocio Salas-Whalen shares scientific support, as well as applicable anecdotes and wisdom, from her numerous years of experience with prescribing GLP-1s and briefly using them herself.

How the book is structured/main topics:
The book is broken into three main sections. The first four chapters outlines factors that may lead to obesity and how the medications work. It helps the reader appreciate the comprehensive number of factors that can lead to obesity, provides a history of GLP-1s, and thoughts to help readers decide how to evaluate if GLP-1s are the right choice and options on where to get it prescribed.

Chapters 5 to 7 focus on taking the medication, such as starting doses and when to titrate higher, considerations on what day to dose, and the importance of prioritizing protein and strength training to maintain muscle. It also covers side effects and adjusting dosages.

The final two chapters covers what happens after you’ve reached your goal for body recomposition. Dr. Salas-Whalen explains the options for titration down to a lower dose or even going off the medication if necessary, but the emphasis is that obesity is a chronic condition and many will likely require some type of maintenance dose. It also discusses the mental and emotional adjustments, not just physical ones, which people face with weight loss and changes in their health.

There are also a few quick reference sheets for protein and for appointment checklists to guide prep to converse with your prescribing medical professional.


Additional thoughts:

As someone who has done a fair amount of online research on GLP-1s, the book echoed many of the same points with which I was familiar. The author’s tone seems friendly yet professional, and while she shares many factors that may contribute to an individual’s obesity, it didn’t come across as judgment or subtly snarky. I would have appreciated having this book a year ago when I was having conversations with my primary doctor about starting a GLP-1 med; having a one-stop resource at home to kick things off would have been useful. I have been taking tirzepatide pen injections for almost a year now, and I have experienced some common side effects, as well as several less common ones, although none have been serious enough that I needed to discontinue the medication. I thought it was important how much she emphasized the need to maintain adequate protein because it is difficult, and she provided sample menus on how to achieve such. It’s great to be prepared and know the history of the meds, but actually taking the medication can be quite an adjustment for many people. More depth on troubleshooting side effects would be useful—it’s covered, but side effects can be detailers that make people feel like quitting early so having more on that topic seems like it would be welcomed by many. Also, for those with more to lose, my perception is that there can be many more plateaus or adjustments needed, partly due to the longer duration. I felt like it took a lot of trial and error and know that I am not alone in feeling that way.

Overall, the book is a solid guide, and I will recommend it or gift it to others who are early in their journey. Thank you to Netgalley, the author, and Rodale Books for the ARC. All opinions are my own.

[Betty Panik · Rating 5 out of 5]

This book was a must read for anyone struggling with their weight and considering taking any weight loss drugs.

The author starts with apologizing to all obese patients who she told to stop eating and exercise and they would lose weight. She said that obesity is a disease and not a matter of willpower.
She then went on to describe the many factors that cause the disease of obesity: genes and environment, hormones, life stages, emotions, endocrine disrupting chemicals in plastics and personal care products, medications, lack of sleep, stress, and metabolic slowdown as we age due to muscle loss, lower protein intake and reduced physical activity.

Stories of her patient’s journeys were also helpful to emphasize how obesity is a disease and is so hard to control.

Metrics for health and weight management were thoroughly explained including fat measurement, lipid profiles and inflammatory markers.

The thorough review of the history of GLP-1 medications was eye-opening to me because it made me realize how long these drugs have been used successfully and how they have been improved over the years. A comparison explanation of FDA approved medications versus compounded medications was important to know for the safety of anyone considering taking these drugs. Explanations of the different generations of these drugs and how they work was extremely informative.
Questions to ask when looking for a provider for your GLP-1 journey, what to expect when you start, how to monitor progress, and even storing the medications was thoroughly discussed.
Guiding the patient to optimal results was explored. She described the importance of preserving muscle to help burn fat by eating enough protein and strength training. She went into detail about the composition of protein, what constitutes a complete amino acid and a nonessential amino acid. She even included sample menus to ensure you eat enough protein.
She went over what to do once you hit your goal weight; decreasing dosages vs getting off the drug completely. Psychological effects of large weight loss including how to handle positive as well as negative comments, and excess skin loss was described as an important part of the journey that must be considered.

This book is an invaluable resource for everyone to understand the disease of obesity and how these drugs help control it. It is written in such a way that ANYONE can understand it. This is so important so people without a science background can understand these drugs and make informed decisions when considering starting this journey to better health.
I highly recommend this book for all people, not just obese people, so obesity can lose its stigma and people will be less judgmental and more compassionate towards people with this disease.

I thank Netgalley and the publisher for giving me the privilege to read an advanced reader copy of this outstanding book. I am writing this review honestly and voluntarily.

[Pamela Shrewsbury · Rating 5 out of 5]

✨ ARC REVIEW ✨
TITLE: Weightless
AUTHOR: Dr. Rocio Salas-Whalen
PUBLICATION DATE: Dec 29, 2025
PUBLISHER: Rodale Books
RATING: ⭐️⭐️⭐️⭐️⭐️

Dr. Salas-Whalen, a board-certified endocrinologist, delivers a groundbreaking guide to GLP-1 medications—Ozempic, Wegovy, Mounjaro, and Zepbound—and reframes obesity as a chronic, biologically driven condition rather than a personal failure. The book breaks down the science in an accessible, judgment-free way, explaining what these medications do inside the body, who they’re appropriate for, and how to use them safely.

The focus is on reversing obesity with evidence-based tools, not quick fixes. The tone feels supportive and practical, giving readers the confidence to advocate for themselves and understand their options in a medical landscape that can feel overwhelming. I also appreciated the emphasis on reducing shame, cutting through misinformation, and helping readers make informed decisions about their health.

💡 What makes this book stand out:
— The GPS protocol: GLP-1 + Protein + Strength training, designed to protect muscle and metabolism while losing fat.
— Myth-busting clarity: From “Ozempic face” to viral misconceptions, she dismantles hype with science.
— Emotional ripple effects: How weight loss shifts relationships, identity, and self-image—and how to navigate those changes with compassion.
— Midlife resonance: Insight into perimenopause and menopause, explaining why traditional diets often fail and how GLP-1s can help.
— Patient stories: Real voices that make the science personal, showing both triumphs and challenges.

This isn’t a quick-fix manual—it’s science, strategy, and soul. Salas-Whalen’s tone is warm, direct, and deeply respectful, offering readers a roadmap to reclaim their health with clarity and confidence.

If you’re exploring GLP-1 meds or simply want a trustworthy, medically grounded resource in a topic full of noise, Weightless is absolutely worth keeping on your radar.

Thank you to NetGalley, Dr. Rocio Salas-Whalen, and Rodale Books for the ARC.

#ARCReview #WeightlessBook #GLP1Medications #BookTherapy #HealthLit #Ozempic #Wegovy #Mounjaro #Zepbound #RodaleBooks #Bookstagram #NonfictionReads #MidlifeWellness #BodyAutonomy #MentalHealthMatters #BookReview

[Mechele · Rating 5 out of 5]

Weightless
Authored by Rocio Salas-Whalen, MD

I was very skeptical about this book, but found it to contain some very good information presented in a supportive way for people struggling with weight and metabolism issues. Dr. Salas-Whalen is very compassionate and writes this book for non-medical personnel, so it is easily digestible (pun intended). I can not vouch for the studies used, but most of the information appears solid and helpful.

Dr. Salas-Whalen gives information on the history of the American medical establishment providing uninformed care and traumatizing many people who struggle with weight issues. She discusses the history of GLP-1s and demystifies them along with framing them as part of good healthcare. She carefully lets the reader know of any problems they may encounter with the medications be they physical or psychological. She outlines the importance of healthy eating and stresses the importance of resistance/weight training. She further talks about aftercare once one’s health goals are met, which I found to be helpful.

This is a very positive book on how GLP-1s (and other medications) can be used to help people with Type II Diabetes Mellitus as well as those struggling with metabolism and weight issues. It is framed in a person-centered helpful way with minimal scare tactics- she does discuss the medical complications that can/ do exist for people who struggle with weight. It also addresses stigmas and myths surrounding medical weight loss and health.

Dr. Salas-Whalen’s book takes you from contemplation to taking action and all of the steps in between sequentially until you have met your “body composition” goals and are in the maintenance phase. This is a good place to start if you are considering a GLP-1 and gives you talking points you can bring to your physician. It also addresses stigmas and myths surrounding medical weight loss and health.

My thanks to Rodale/Random House for allowing me to read this ARC in exchange for my review.