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Your Best Shot: The Personalized System for Optimal Weight Health―GLP-1 Shot or Not
The real revolution of the GLP-1 shots is the insight that the body regulates appetite and more with the hormones GLP-1, GIP, PYY, and CCK—and with Your Best Shot in hand, you can learn to optimize their function and your weight health for life.
Whether you have a little or a lot of fat to lose, cravings to curb, or use a shot or don’t, weight health hormone optimization is your best shot. Over two decades of research in her practice, renowned weight health expert Ashley Koff, RD, developed this game-changing system for patients and practitioners. Taking your best shot, you:
*determine whether your weight-health hormone function is suboptimal
*identify your suboptimal-function type and narrow down causes
*get specific, targeted, doable recommendations
*use experiments to lock in on your better choices
*develop strategies to tune out food noise and fight infobesity
*learn how to vet the growing number of weight-health hormone-targeting medications, supplements, and devices
*discover why better, not perfect, is the route to optimized health
*choose the methods and tools you'll use to reset your course whenever life happens
This evidence-based program is for anyone pursuing weight health—the majority of us not using a weight health hormone replacement, along with the millions who are, or are ready to come off it.
Your Best Shot is not another plan. It’s your plan.
Whether you have a little or a lot of fat to lose, cravings to curb, or use a shot or don’t, weight health hormone optimization is your best shot. Over two decades of research in her practice, renowned weight health expert Ashley Koff, RD, developed this game-changing system for patients and practitioners. Taking your best shot, you:
*determine whether your weight-health hormone function is suboptimal
*identify your suboptimal-function type and narrow down causes
*get specific, targeted, doable recommendations
*use experiments to lock in on your better choices
*develop strategies to tune out food noise and fight infobesity
*learn how to vet the growing number of weight-health hormone-targeting medications, supplements, and devices
*discover why better, not perfect, is the route to optimized health
*choose the methods and tools you'll use to reset your course whenever life happens
This evidence-based program is for anyone pursuing weight health—the majority of us not using a weight health hormone replacement, along with the millions who are, or are ready to come off it.
Your Best Shot is not another plan. It’s your plan.
- GenresHealth
368 pages, Hardcover
Published January 6, 2026
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Displaying 1 - 12 of 12 reviews
September 3, 2026
I listened to this book and found it fascinating. While I have no need for the GLP1 shot/pill it was interesting learning about why it works. I’d like to buy the book and use the resource material that goes with it to help experiment in optimizing myself. She provides a lot of information on why certain supplements work and how they can also be a roadblock. I liked her analogies of building a pizza and referring to meals and snacks as pit stops. I like her approach to weight management. She makes it clear that everyone is different and has different deal breakers that will work for them.
February 21, 2026
Inspirational wellness playbook—Avoids the hype / echo chamber / armchair advice.
I got a copy of Your Best Shot by Ashley Koff, RD, as part of my work in nutrition science.
The book covers GLP-1 and weight-health hormones, but it’s really more of a complete wellness and personal growth guide than just a book about “shots.” The main message is about empowerment: meet yourself where you are, find what works for you, and keep pushing yourself, even when it’s tough. It mixes science with practical advice you can use every day.
Here’s what stood out to me: a practical structure that doesn’t expect perfection, clear and motivating advice for any starting point, a focus on steady progress instead of quick fixes, and the idea of creating your own Pizza (if you know, you know!).
Whether you’re new to wellness or have been at it for a while, this book can help you pause and refocus, so you don’t get distracted by all the hype out there.
I got a copy of Your Best Shot by Ashley Koff, RD, as part of my work in nutrition science.
The book covers GLP-1 and weight-health hormones, but it’s really more of a complete wellness and personal growth guide than just a book about “shots.” The main message is about empowerment: meet yourself where you are, find what works for you, and keep pushing yourself, even when it’s tough. It mixes science with practical advice you can use every day.
Here’s what stood out to me: a practical structure that doesn’t expect perfection, clear and motivating advice for any starting point, a focus on steady progress instead of quick fixes, and the idea of creating your own Pizza (if you know, you know!).
Whether you’re new to wellness or have been at it for a while, this book can help you pause and refocus, so you don’t get distracted by all the hype out there.
April 1, 2026
Not a lot of GLP1 info but lots of good nutrition information and she has you gather a bunch of data about yourself to be evaluated. That can be fun and informative to do. She goes over your results and how to interpret them.
May 5, 2026
Game changer! Ashley talks about real things for real people in a way you can understand. Bonus: she’s not trying to sell you a bunch of unnecessary things!
Good common sense advice for those that struggle with weight health given with the analogy of a pizza of all things!
Good common sense advice for those that struggle with weight health given with the analogy of a pizza of all things!
Review of advance copy received from Netgalley
Your Best Shot aims to simplify weight health through understanding key appetite-related hormones, as well as the popular GLP-1 medications. While the framing is timely, the book feels more like an attempt to ride the GLP-1 wave than a genuinely innovative resource. It promises a personalized system, but much of the advice is very familiar to anyone who has read other wellness or nutrition books.
Koff lays out multiple assessment tools and self-reflection exercises, which could be helpful for beginners. However, these sections rely heavily on general lifestyle principles rather than deep, actionable insights about hormone optimization. The material often circles around the same ideas without adding new layers, making the book feel longer than it needs to be.
Readers who expect a more scientific or critical look at GLP-1 medications may be disappointed. While the book touches on medication decisions, supplements, and devices, the coverage is broad rather than thorough. It stays at a safe, introductory level instead of digging into the complexities of how these tools can affect weight or health long-term.
There are positive elements, such as the focus on self-awareness, realistic expectations, and compassion. But in the end, the book does not offer enough depth or originality to distinguish itself. If you are new to wellness or want very basic guidance, it could work. If you are looking for more than that, this one may fall short.
Koff lays out multiple assessment tools and self-reflection exercises, which could be helpful for beginners. However, these sections rely heavily on general lifestyle principles rather than deep, actionable insights about hormone optimization. The material often circles around the same ideas without adding new layers, making the book feel longer than it needs to be.
Readers who expect a more scientific or critical look at GLP-1 medications may be disappointed. While the book touches on medication decisions, supplements, and devices, the coverage is broad rather than thorough. It stays at a safe, introductory level instead of digging into the complexities of how these tools can affect weight or health long-term.
There are positive elements, such as the focus on self-awareness, realistic expectations, and compassion. But in the end, the book does not offer enough depth or originality to distinguish itself. If you are new to wellness or want very basic guidance, it could work. If you are looking for more than that, this one may fall short.
February 22, 2026
As a former Hospital Pharmacist, I found Ashley's book to contain excellent advice for the general population. Ashley does a fabulous job of breaking down the science into practical steps leading toward steady progress. She gives empowering advice that is needed when discussing medications. She understands what Americans are up against in our ultra-processed landscape and encourages us to take agency for our health. I learned that I'm a hose and how to become a sponge, highly recommend this resource!
February 20, 2026
No one makes how to live a healthy life with good nutrition and other lifestyle options more useful and realistic! Ashely has the gift of clear communication and the expertise and credentials to back it up. With the current GLP -1 obsession happening today - this book is ESSENTIAL! My boyfriend is on a GLLP-1 and Ashely helped us understand the pro's and con's in a simplified, personalized and digestible (sorry!) way....LOVE Ashley and this book!
August 26, 2026
Really poorly written. Out of all the books I've read related to GLP-1 use, this was one of the worst. It purports to be scientific but there's a lot of pseudoscience or straight up inaccurate information. If you are on a GLP-1, skip this book. Weightless by Dr. Rocio Salas-Whalen is a far better read with higher quality information.
January 14, 2026
This book is a game-changer for thinking about weight health. Ashley does an amazing job sharing the science and stories in a way that is both digestible and inspirational for taking care of ourselves. This is a must-read!!!
September 6, 2026
Love that book is not another one-size-fits-all diet plan. The author helps you identify your specific hormone-function type and explains how to work with your body - whether you use a GLP-1 shot or not. Warm, precise, and funny. This is a lasting-fix book. Highly recommended!
March 30, 2026
I'm sure there's good advice in here, but the book desperately needs an editor
September 2, 2026
Overall felt the writing style a little distracting. I thought the pizza metaphor was unfortunate. And overall didn’t seem to have a lot of specific information.
Displaying 1 - 12 of 12 reviews