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Your Best Shot: The Personalized System for Optimal Weight Health―GLP-1 Shot or Not
The real revolution of the GLP-1 shots is the insight that the body regulates appetite and more with the hormones GLP-1, GIP, PYY, and CCK—and with Your Best Shot in hand, you can learn to optimize their function and your weight health for life.
Whether you have a little or a lot of fat to lose, cravings to curb, or use a shot or don’t, weight health hormone optimization is your best shot. Over two decades of research in her practice, renowned weight health expert Ashley Koff, RD, developed this game-changing system for patients and practitioners. Taking your best shot, you:
*determine whether your weight-health hormone function is suboptimal
*identify your suboptimal-function type and narrow down causes
*get specific, targeted, doable recommendations
*use experiments to lock in on your better choices
*develop strategies to tune out food noise and fight infobesity
*learn how to vet the growing number of weight-health hormone-targeting medications, supplements, and devices
*discover why better, not perfect, is the route to optimized health
*choose the methods and tools you'll use to reset your course whenever life happens
This evidence-based program is for anyone pursuing weight health—the majority of us not using a weight health hormone replacement, along with the millions who are, or are ready to come off it.
Your Best Shot is not another plan. It’s your plan.
Whether you have a little or a lot of fat to lose, cravings to curb, or use a shot or don’t, weight health hormone optimization is your best shot. Over two decades of research in her practice, renowned weight health expert Ashley Koff, RD, developed this game-changing system for patients and practitioners. Taking your best shot, you:
*determine whether your weight-health hormone function is suboptimal
*identify your suboptimal-function type and narrow down causes
*get specific, targeted, doable recommendations
*use experiments to lock in on your better choices
*develop strategies to tune out food noise and fight infobesity
*learn how to vet the growing number of weight-health hormone-targeting medications, supplements, and devices
*discover why better, not perfect, is the route to optimized health
*choose the methods and tools you'll use to reset your course whenever life happens
This evidence-based program is for anyone pursuing weight health—the majority of us not using a weight health hormone replacement, along with the millions who are, or are ready to come off it.
Your Best Shot is not another plan. It’s your plan.
368 pages, Hardcover
Published January 6, 2026
8 people are currently reading
32 people want to read
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Displaying 1 - 5 of 5 reviews
Review of advance copy received from Netgalley
Your Best Shot aims to simplify weight health through understanding key appetite-related hormones, as well as the popular GLP-1 medications. While the framing is timely, the book feels more like an attempt to ride the GLP-1 wave than a genuinely innovative resource. It promises a personalized system, but much of the advice is very familiar to anyone who has read other wellness or nutrition books.
Koff lays out multiple assessment tools and self-reflection exercises, which could be helpful for beginners. However, these sections rely heavily on general lifestyle principles rather than deep, actionable insights about hormone optimization. The material often circles around the same ideas without adding new layers, making the book feel longer than it needs to be.
Readers who expect a more scientific or critical look at GLP-1 medications may be disappointed. While the book touches on medication decisions, supplements, and devices, the coverage is broad rather than thorough. It stays at a safe, introductory level instead of digging into the complexities of how these tools can affect weight or health long-term.
There are positive elements, such as the focus on self-awareness, realistic expectations, and compassion. But in the end, the book does not offer enough depth or originality to distinguish itself. If you are new to wellness or want very basic guidance, it could work. If you are looking for more than that, this one may fall short.
Koff lays out multiple assessment tools and self-reflection exercises, which could be helpful for beginners. However, these sections rely heavily on general lifestyle principles rather than deep, actionable insights about hormone optimization. The material often circles around the same ideas without adding new layers, making the book feel longer than it needs to be.
Readers who expect a more scientific or critical look at GLP-1 medications may be disappointed. While the book touches on medication decisions, supplements, and devices, the coverage is broad rather than thorough. It stays at a safe, introductory level instead of digging into the complexities of how these tools can affect weight or health long-term.
There are positive elements, such as the focus on self-awareness, realistic expectations, and compassion. But in the end, the book does not offer enough depth or originality to distinguish itself. If you are new to wellness or want very basic guidance, it could work. If you are looking for more than that, this one may fall short.
February 21, 2026
Inspirational wellness playbook—Avoids the hype / echo chamber / armchair advice.
I got a copy of Your Best Shot by Ashley Koff, RD, as part of my work in nutrition science.
The book covers GLP-1 and weight-health hormones, but it’s really more of a complete wellness and personal growth guide than just a book about “shots.” The main message is about empowerment: meet yourself where you are, find what works for you, and keep pushing yourself, even when it’s tough. It mixes science with practical advice you can use every day.
Here’s what stood out to me: a practical structure that doesn’t expect perfection, clear and motivating advice for any starting point, a focus on steady progress instead of quick fixes, and the idea of creating your own Pizza (if you know, you know!).
Whether you’re new to wellness or have been at it for a while, this book can help you pause and refocus, so you don’t get distracted by all the hype out there.
I got a copy of Your Best Shot by Ashley Koff, RD, as part of my work in nutrition science.
The book covers GLP-1 and weight-health hormones, but it’s really more of a complete wellness and personal growth guide than just a book about “shots.” The main message is about empowerment: meet yourself where you are, find what works for you, and keep pushing yourself, even when it’s tough. It mixes science with practical advice you can use every day.
Here’s what stood out to me: a practical structure that doesn’t expect perfection, clear and motivating advice for any starting point, a focus on steady progress instead of quick fixes, and the idea of creating your own Pizza (if you know, you know!).
Whether you’re new to wellness or have been at it for a while, this book can help you pause and refocus, so you don’t get distracted by all the hype out there.
February 22, 2026
As a former Hospital Pharmacist, I found Ashley's book to contain excellent advice for the general population. Ashley does a fabulous job of breaking down the science into practical steps leading toward steady progress. She gives empowering advice that is needed when discussing medications. She understands what Americans are up against in our ultra-processed landscape and encourages us to take agency for our health. I learned that I'm a hose and how to become a sponge, highly recommend this resource!
February 20, 2026
No one makes how to live a healthy life with good nutrition and other lifestyle options more useful and realistic! Ashely has the gift of clear communication and the expertise and credentials to back it up. With the current GLP -1 obsession happening today - this book is ESSENTIAL! My boyfriend is on a GLLP-1 and Ashely helped us understand the pro's and con's in a simplified, personalized and digestible (sorry!) way....LOVE Ashley and this book!
January 14, 2026
This book is a game-changer for thinking about weight health. Ashley does an amazing job sharing the science and stories in a way that is both digestible and inspirational for taking care of ourselves. This is a must-read!!!
Displaying 1 - 5 of 5 reviews