The Folate Fix: Exploring the Role of Folate in Autism and Neurodevelopmental Disorders

by Richard Frye

This book explores the extraordinary role of folate in the body. While folate may not be a magic cure-all, its vital importance for essential bodily functions makes it nothing short of miraculous for those who lack it. Although folate deficiency was first identified over a century ago, recent medical advancements have revealed that this deficiency can be localized to the brain—a condition known as cerebral folate deficiency (CFD).

CFD is a serious yet often overlooked syndrome that can lead to neurodevelopmental and psychiatric symptoms, including epilepsy. Most notably, CFD has been linked to autism spectrum disorder (ASD), a condition affecting an increasing number of children worldwide. Many children with ASD may have unrecognized, yet treatable, folate abnormalities. Fortunately, CFD is treatable with leucovorin—a safe and effective form of folate, also known as folinic acid (distinct from folic acid). Leucovorin can cross into the central nervous system, correcting folate deficiency in the brain and significantly alleviating symptoms. This treatment offers new hope for individuals with CFD and ASD.

This book serves as both an informative guide and a practical resource for understanding and addressing folate abnormalities. It features inspiring stories from parents of children with neurodevelopmental disorders who have witnessed remarkable improvements with CFD treatment. Additionally, it provides clinicians and caregivers with essential tools, including evaluation strategies, treatment best practices, and answers to frequently asked questions. By shedding light on this well-tolerated, life-changing treatment, this book aims to empower families and healthcare professionals alike—offering hope, healing, and a path toward better outcomes for those affected by folate-related disorders.

475 pages, Kindle Edition

Published April 8, 2025

Reviews

[Frrobins · Rating 5 out of 5]

As someone with two autistic children, and who worked with children with autism long before becoming a parent, I completely understand why some people might initially dismiss this as snake oil. But I urge readers to give it a chance.

Unlike many purported treatments for autism, this one has a plausible biological mechanism and screening tools. As many people are discovering, the results often speak for themselves. I also found the chapters on vaccines and genetics refreshing, given how contentious those topics have become. The book helped me feel reassured, too, because I had been trying to trace genetic causes for autism in my family without success, and it explained other mechanisms that could account for why autism sometimes runs in families.

This book provides a solid overview of what folate is, the role it plays in development, and how folate deficiencies can contribute to a range of conditions, including autism. It includes case studies, information on comorbid conditions such as mitochondrial dysfunction, and guidance on treating Cerebral Folate Deficiency.

My 14-year-old son has level 2 autism. After testing, we discovered that he has a high level of binding antibodies, and we started him on folinic acid four weeks ago. Even though he isn’t yet on a full therapeutic dose, we’re already seeing encouraging progress, especially in his conversational skills. Several teachers have commented on his improvements, saying they haven’t seen anything like it before.

I strongly recommend this book to families affected by autism.

[Grace · Rating 5 out of 5]

Folinic acid is healing my boy. He was diagnosed with autism at age 3, now at 7 after being on folinic acid I think his diagnosis is wrong.