Fever: Basic Mechanisms and Management

by Philip A. Mackowiak (Editor)

Completely revised and updated, the new edition of this essential text continues to serve as a comprehensive reference on the basic mechanisms, physiological consequences, clinical characteristics, and management of fever. The book provides an in-depth analysis of clinical thermometry, thermoregulation, endogenous and exogenous pyrogens, the role of prostaglandins in fever, the immunological consequences of fever, the cardiovascular alterations that occur during fever, the role of fever in host defense against pathogenic microorganisms, and the significance of the fever pattern in clinical diagnosis. Leading authorities offer guidelines on diagnosis and treatment of fever of unknown origin, postoperative fever, drug-induced fever, and fever in infants, children, the elderly, and the immunocompromised patient. The pharmacology and clinical use of antipyretics and the influence of fever on pharmacokinetics and pharmacodynamics are also discussed in detail. The Second Edition is more clinically focused and features new experts, ten new chapters, and more complete coverage.

506 pages, Hardcover

First published December 1, 1990