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Beyond Inheritance: Our Ever-Mutating Cells and a New Understanding of Health

Not yet published
Expected 21 Apr 26
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The new science of how our DNA mutates over our lifetimes, with radical implications for our health and medical treatments.

We tend to think of Darwinian evolution as a process that plays out over generations. But our understanding of natural selection is itself evolving. Science writer Roxanne Khamsi reveals our bodies as active landscapes of evolution. Genetic mutations are constantly happening within your body—even as you read this.

In this astonishing book, Khamsi shows how our bodies comprise cells that change over the course of a lifetime, mutating, competing, and evolving. Our immune systems fight viruses by evolving millions of different cells that produce distinct antibodies for dealing with invaders, while cancer and bacterial cells evolve in response to our bodies’ attempts to destroy them. Meanwhile, the random mutations of cells throughout our bodies have immense potential to harm us—and heal us.

Beyond Inheritance reveals our DNA as a dynamic, mutating entity. By letting go of the antiquated idea that each cell has the same exact DNA and embracing a messier—but truer—reality, we can usher in a whole new era of medicine. Khamsi introduces readers to the scientists who are harnessing evolutionary forces to design vaccines and to battle cancer. This book will open your eyes to the immense and ongoing genetic diversity that exists within each human body and its incredible potential to impact your health and well-being.

304 pages, Hardcover

Expected publication April 21, 2026

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About the author

Roxanne Khamsi

2 books1 follower
Roxanne Khamsi is a writer and editor formerly based in Brooklyn and now living in Montreal. Her articles have appeared in publications such as The New York Times, The Economist, Popular Science, Scientific American, Slate, Nature, New York magazine, WIRED magazine and the MIT Technology Review.

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805 reviews37 followers
Review of advance copy received from Netgalley
December 17, 2025
I found this book informative. Although the actual science can be quite complex, I think that Khamsi did a good job of translating it into plain language. I also liked the case-based approach and the author’s journey. And I did chuckle a couple of times over some of the clever writing. Overall, this book was well worth reading. Thank you to Edelweiss and Riverhead Books for the advance reader copy.
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