Runaway Grannies tells the story of two middle-aged women who find themselves bound together in an unlikely friendship that takes them on an event-filled frolic into their later years, both finding themselves living their best lives and learning to love again after experiencing life-altering loss. In order to save the family they both share from imminent financial catastrophe, the two leave behind the comfort of their separate lives, hatching a plan that sees them sharing a basement suite in the family home. The two women, as unlikely room mates, find themselves bonding in a friendship that neither could have imagined.