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Enough: Your Health, Your Weight, and What It's Like To Be Free
For her entire adult life, Oprah Winfrey has struggled with her weight. She never thought in her lifetime, medicines would provide hope, health, and healing for people like her. But as her conversations with Dr. Ania Jastreboff from the Yale School of Medicine reveal, we’ve learned that having obesity is not a choice. It’s not a question of willpower.Obesity is a disease.
It’s a biological challenge, created by the intersection of our inherent need to survive and the environment we created and now live in.
And it’s treatable.
The new medications can lower our body fat set point (our brain’s “Enough Point”), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimize health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications.
Many of her patients say the “food noise” that plagued them for years has evaporated. They describe a new freedom from intrusive, persistent, and disruptive thoughts about food. With treatment they begin a journey of healing with self-compassion, devoid of the shame and blame they’ve endured from society for decades.
Oprah says she’s learned so much from Dr. Jastreboff about how, when it comes to weight, our bodies work with us—and also against us. How each of our struggles are different and each of our choices in living with obesity may also be different.
Dr. Jastreboff’s groundbreaking research offers a new way forward, not only for obesity treatment, but for overall health, with significant implications for the prevention and reversal of hundreds of related diseases. As she demonstrates in this book, when science meets empathy, real healing becomes possible.
Yes, there is a path to healing and leading the life you have always wanted, when your brain is reassured that you have “enough”.
It’s a biological challenge, created by the intersection of our inherent need to survive and the environment we created and now live in.
And it’s treatable.
The new medications can lower our body fat set point (our brain’s “Enough Point”), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimize health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications.
Many of her patients say the “food noise” that plagued them for years has evaporated. They describe a new freedom from intrusive, persistent, and disruptive thoughts about food. With treatment they begin a journey of healing with self-compassion, devoid of the shame and blame they’ve endured from society for decades.
Oprah says she’s learned so much from Dr. Jastreboff about how, when it comes to weight, our bodies work with us—and also against us. How each of our struggles are different and each of our choices in living with obesity may also be different.
Dr. Jastreboff’s groundbreaking research offers a new way forward, not only for obesity treatment, but for overall health, with significant implications for the prevention and reversal of hundreds of related diseases. As she demonstrates in this book, when science meets empathy, real healing becomes possible.
Yes, there is a path to healing and leading the life you have always wanted, when your brain is reassured that you have “enough”.
- GenresNonfictionAudiobook
288 pages, Hardcover
Published January 13, 2026
536 people are currently reading
349 people want to read
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Displaying 1 - 6 of 6 reviews
January 14, 2026
To be clear, this is not a book about Oprah. She is only a small part of this book. It is about obesity as a disease and treating this disease with modern medicine, namely GLP-1s in all their forms. A well-written book--technical at times--but it's easy to gloss over those sections. The medical world is finally getting it!
January 20, 2026
Sadly, I’m really disappointed in this book. I’ve had it on pre-order for months and, based on the interviews and podcasts I’ve seen with Dr. Ania and Oprah on this topic I had such high hopes for it. But it’s missing a huge piece of the puzzle in my opinion…the mental health component of obesity. The book is very clinically/medically focused which I get since it was written by a doctor, but I would have liked to have heard more from Oprah in it. More like the book she co-wrote with Dr Perry. Better yet, it it could have been co-authored by a psychologist that would have added a critical dimension on the topic. She does mention briefly that 40% of people with obesity have depression and even more have anxiety. What are the links between childhood trauma and severe obesity? They’re significant…I’ve seen stats on them. GLP1s will help but unless the mental and emotional component is also addressed it’s only one puzzle piece to a very complex puzzle. More needs to be explored and discussed openly on that aspect of this topic.
January 18, 2026
Interesting read, but I still find it unsettling that everyone and their mother is turning into a literal bobblehead these days.
January 18, 2026
I grew up an Oprah fan and was curious what she had to say in this book. I appreciate her sharing about her food freedom journey. But it is also about the science of GLP-1 medications.
January 18, 2026
5++ stars. I relate to SO MUCH of this book. Thank you to the authors for writing it.
January 19, 2026
The science behind GLP’s. Very little Oprah except for her endorsement of how she f e e l s now.
“Your mind is never clear. Obesity is not a choice. It is confused biology.”
“Your mind is never clear. Obesity is not a choice. It is confused biology.”
Displaying 1 - 6 of 6 reviews