Enough: Your Health, Your Weight, and What It's Like To Be Free

by Oprah Winfrey, Ania M. Jastreboff Jastreboff

*THE INSTANT NEW YORK TIMES BESTSELLER*. For her entire adult life, Oprah Winfrey has struggled with her weight. She never thought in her lifetime, medicines would provide hope, health, and healing for people like her. But as her conversations with Dr. Ania Jastreboff from the Yale School of Medicine reveal, we’ve learned that having obesity is not a choice. It’s not a question of willpower.

Obesity is a disease.

It’s a question of biology, created by our bodies' need to survive and the environment we created and now live in.

And it’s treatable.

The new medications can lower our body fat set point (our brain’s 'Enough Point'), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimise health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications.

Many of her patients say the 'food noise' that plagued them for years has evaporated. They describe a new freedom from intrusive, persistent and disruptive thoughts about food. With treatment they begin a journey of healing with self-compassion, devoid of the shame and blame they’ve endured from society for decades.

Oprah says she’s learned so much from Dr. Jastreboff about how, when it comes to weight, our bodies work with us — and also against us. How each of our struggles are different and each of our choices in living with obesity may also be different.

Dr. Jastreboff’s groundbreaking research offers a new way forward, not only for obesity treatment, but also for overall health, with significant implications for the prevention and reversal of hundreds of related diseases. As she demonstrates in this book, when science meets empathy, real healing becomes possible.

Yes, there is a path to healing and leading the life you have always wanted, when your brain is reassured that you have 'enough.'

Genres: Audiobook, Nonfiction, Health

Audible Audio

Published January 16, 2026

About the author

Oprah Gail Winfrey, also known mononymously as Oprah, is an American talk show host, television producer, actress, author, and media proprietor. She is best known for her talk show, The Oprah Winfrey Show, broadcast from Chicago, which ran in national syndication for 25 years, from 1986 to 2011. Dubbed the "Queen of All Media", she was the richest African-American of the 20th century and was once the world's only black billionaire. By 2007, she was often ranked as the most influential woman in the world.
Winfrey was born into poverty in rural Mississippi to a single teenage mother and later raised in inner-city Milwaukee. She has stated that she was molested during her childhood and early teenage years and became pregnant at 14; her son was born prematurely and died in infancy. Winfrey was then sent to live with the man she calls her father, Vernon Winfrey, a barber in Nashville, Tennessee, and landed a job in radio while still in high school. By 19, she was a co-anchor for the local evening news. Winfrey's often emotional, extemporaneous delivery eventually led to her transfer to the daytime talk show arena, and after boosting a third-rated local Chicago talk show to first place, she launched her own production company.
Credited with creating a more intimate, confessional form of media communication, Winfrey popularized and revolutionized the tabloid talk show genre pioneered by Phil Donahue. By the mid-1990s, Winfrey had reinvented her show with a focus on literature, self-improvement, mindfulness, and spirituality. Though she has been criticized for unleashing a confession culture, promoting controversial self-help ideas, and having an emotion-centered approach, she has also been praised for overcoming adversity to become a benefactor to others. Winfrey also emerged as a political force in the 2008 presidential race, with her endorsement of Barack Obama estimated to have been worth about one million votes during the 2008 Democratic primaries. In the same year, she formed her own network, the Oprah Winfrey Network (OWN). In 2013, Winfrey was awarded the Presidential Medal of Freedom by President Barack Obama.
In 1994, she was inducted into the National Women's Hall of Fame. Then in October, she finished the Marine Corps Marathon in less than four and a half hours. She has received honorary doctorate degrees from multiple universities. Winfrey has won many awards throughout her career, including 19 Daytime Emmy Awards (including the Lifetime Achievement Award and the Chairman's Award), two Primetime Emmy Awards (including the Bob Hope Humanitarian Award), a Tony Award, a Peabody Award, and the Jean Hersholt Humanitarian Award awarded by the Academy Awards, in addition to two competitive Academy Award nominations. Winfrey was elected as a member of the American Academy of Arts and Sciences in 2021.

Reviews

[Dee · Rating 3 out of 5]

Oprah continues to be a communicator, and here she has partnered with a leading doctor to discuss obesity as an illness, similar to alcohol or addictive drugs, not a matter of will power or absence. I think this will help a lot of people who are considering taking a GLP 1 or a family member of someone who is struggling with their weight.

[Bethany Blum · Rating 4 out of 5]

I think this was a great resource for anyone who is wanting to understand more about the disease of obesity, the biology behind it, the role that medications play, and new medications on the horizon. For anyone who has spent any time doing research on the topic or has followed Oprah and watched her special on obesity and GLP-1s, this book will likely not provide any new insights or information.

[Eleta · Rating 5 out of 5]

Vulnerable post/review! Oprah and Dr. Ania Jastreboff, a Yale endocrinologist, do a deep dive into the biology of obesity and the history of the treatment, perceptions, and missteps in the medical community regarding obesity. A major thread of the book is the emergence of GLP-1 medications and the life-lengthening effects of this drug for millions of people. If you've seen the movie Good Will Hunting, you know the famous scene with Robin Williams and Matt Damon when Williams' character says, over and over, "it's not your fault." This book is that line for anyone who has been frustrated and befuddled by weight management and a susceptibility to holding excess weight. Understanding the science behind "it's not a lack of willpower, it's personal biology and genetics" is freeing and enlightening. Many folks have wondered why it's easier for some people to maintain a normal weight and feels impossible for others. This book explains why, both in layman's terms and also with the understanding that the book's audience is intelligent and thoughtful. GLP-1 medications should be considered as obesity management drugs, not "weight loss medications," because a person with obesity, inflammation, or other ailments can and will benefit from a lifelong treatment. Understanding hunger and fullness hormones (ghrelin and leptin) and how they weren't discovered in the body until the 1990s (!!!) was fascinating to me. Basically, it may be the case that some of us naturally have less leptin than others, making it harder to know when we've had "enough" (pun intended) food, leading to either eating in excess OR making it incredibly difficult to stay in a calorie deficit for weight loss. If you're interested in nutrition, psychology, and/or physiology and/or you're GLP-1-curious, I highly recommend this book. Oprah and Dr. Ania read the audiobook, which is a treat.

[Cathy Ryan · Rating 4 out of 5]

Really thought-provoking and educational. Filled with a lot of scientific information (which I usually don't like and tend to skip over---but I didn't skip it this time and it was very helpful) as well as excellent ancedotes and lots of comments from Oprah. Well worth the read!!

[Lynn · Rating 4 out of 5]

My third read so far on how GLP1s are changing the world of medicine. Ania has an incredibly empathetic way of looking at obesity (and she has a lovely narration style too). Very interesting to hear Oprah's experiences too. It seems like GLP1s (and 2s and 3) can do no wrong at the moment!

[Donna · Rating 4 out of 5]

If you are considering going on a GLP-1 this is a great resource. Majority of the content is read by the doctor

[Jay · Rating 5 out of 5]

Great information

[Deanna · Rating 2 out of 5]

Although I thought there was some good information, it wasn't my cup of tea.