Enough: Your Health, Your Weight, and What It's Like To Be Free

by Oprah Winfrey, M.D. Ph.D. Ania M. Jastreboff Jastreboff

*THE INSTANT NEW YORK TIMES BESTSELLER*. For her entire adult life, Oprah Winfrey has struggled with her weight. She never thought in her lifetime, medicines would provide hope, health, and healing for people like her. But as her conversations with Dr. Ania Jastreboff from the Yale School of Medicine reveal, we’ve learned that having obesity is not a choice. It’s not a question of willpower.

Obesity is a disease.

It’s a question of biology, created by our bodies' need to survive and the environment we created and now live in.

And it’s treatable.

The new medications can lower our body fat set point (our brain’s 'Enough Point'), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimise health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications.

Many of her patients say the 'food noise' that plagued them for years has evaporated. They describe a new freedom from intrusive, persistent and disruptive thoughts about food. With treatment they begin a journey of healing with self-compassion, devoid of the shame and blame they’ve endured from society for decades.

Oprah says she’s learned so much from Dr. Jastreboff about how, when it comes to weight, our bodies work with us — and also against us. How each of our struggles are different and each of our choices in living with obesity may also be different.

Dr. Jastreboff’s groundbreaking research offers a new way forward, not only for obesity treatment, but also for overall health, with significant implications for the prevention and reversal of hundreds of related diseases. As she demonstrates in this book, when science meets empathy, real healing becomes possible.

Yes, there is a path to healing and leading the life you have always wanted, when your brain is reassured that you have 'enough.'

283 pages, Kindle Edition

Published January 15, 2026

About the author

Oprah Gail Winfrey, also known mononymously as Oprah, is an American talk show host, television producer, actress, author, and media proprietor. She is best known for her talk show, The Oprah Winfrey Show, broadcast from Chicago, which ran in national syndication for 25 years, from 1986 to 2011. Dubbed the "Queen of All Media", she was the richest African-American of the 20th century and was once the world's only black billionaire. By 2007, she was often ranked as the most influential woman in the world.
Winfrey was born into poverty in rural Mississippi to a single teenage mother and later raised in inner-city Milwaukee. She has stated that she was molested during her childhood and early teenage years and became pregnant at 14; her son was born prematurely and died in infancy. Winfrey was then sent to live with the man she calls her father, Vernon Winfrey, a barber in Nashville, Tennessee, and landed a job in radio while still in high school. By 19, she was a co-anchor for the local evening news. Winfrey's often emotional, extemporaneous delivery eventually led to her transfer to the daytime talk show arena, and after boosting a third-rated local Chicago talk show to first place, she launched her own production company.
Credited with creating a more intimate, confessional form of media communication, Winfrey popularized and revolutionized the tabloid talk show genre pioneered by Phil Donahue. By the mid-1990s, Winfrey had reinvented her show with a focus on literature, self-improvement, mindfulness, and spirituality. Though she has been criticized for unleashing a confession culture, promoting controversial self-help ideas, and having an emotion-centered approach, she has also been praised for overcoming adversity to become a benefactor to others. Winfrey also emerged as a political force in the 2008 presidential race, with her endorsement of Barack Obama estimated to have been worth about one million votes during the 2008 Democratic primaries. In the same year, she formed her own network, the Oprah Winfrey Network (OWN). In 2013, Winfrey was awarded the Presidential Medal of Freedom by President Barack Obama.
In 1994, she was inducted into the National Women's Hall of Fame. Then in October, she finished the Marine Corps Marathon in less than four and a half hours. She has received honorary doctorate degrees from multiple universities. Winfrey has won many awards throughout her career, including 19 Daytime Emmy Awards (including the Lifetime Achievement Award and the Chairman's Award), two Primetime Emmy Awards (including the Bob Hope Humanitarian Award), a Tony Award, a Peabody Award, and the Jean Hersholt Humanitarian Award awarded by the Academy Awards, in addition to two competitive Academy Award nominations. Winfrey was elected as a member of the American Academy of Arts and Sciences in 2021.

Reviews

[Diane Hernandez · Rating 4 out of 5]

It’s that time of the year when everyone tries to be healthier. If losing weight is one of your resolutions, using GLP-1 medications are an effective, though expensive, way to make your goal more achievable. Enough is a well-researched book by Oprah’s doctor talking about the pros and cons of these drugs. She explains how your body literally fights any attempts to lose weight by willpower alone. GLP-1 medications can help. Or maybe not, it all depends on your particular biology.

These drugs don’t make you lose weight any faster. You still have to eat less and choose more nutritious food. Strength training is also a must. But both are also necessary when losing weight through traditional diets. So what makes GLP-1 medicines so popular? They quiet your “food noise” or constant thinking about food. They make you feel full after eating a much smaller amount. You will feel full longer too. So following the same diet and exercise rules are just easier.

I learned a lot from the clear explanations within this book. I only have one warning. If you are expecting a book by Oprah, you will be sadly disappointed. Oprah has a few comments within the book but they are mere asides about her experiences with these drugs. Despite this, I still recommend Enough for those thinking of using, or already beginning their journey with, GLP-1 medicines. 4 stars!

Thanks to NetGalley and Avid Reader Press for providing me with an advanced review copy.

[Carolyn Chong · Rating 5 out of 5]

As is expected from Oprah, the book is very accessible and easy to read. She provides anecdotes and her personal experience to connect to readers but the medical research is nicely explained by Dr. Jastreboff. I appreciate the book's work to re-frame the stigma around therapies to treat obesity and the objective input.