This encyclopedic work should be consumed along with other books in the rotation. This is pretty comprehensive, but mostly focuses on the development of Western/scientific medicine. You will get a lot of info about fads along with actual scientific progress. One question I have: why feces were such a prominent ingredient in many drugs before the advent of scientific pharmacology? The author is quite witty a points. When describing the development of Munchausen's syndrome (addiction to surgery) as a diagnosis, he comments, "No label seems to have been devised, however, for surgeons addicted to surgery." The description of various experiments provide some good cocktail party conversation fodder: having healthy patients bitten by infected mosquitos (that one wouldn't have gotten IRB approval); "John Brinkley (1885-1942) made a specialty of implanting goats' testicles, promising his clients sexual rejuvenation and relief of high blood pressure"; the beginnings of understanding of the microbiome show up when doctors transplant (via feeding tubes) the stomach contents of non-anemic patients into the stomachs of anemic patients. If you are interested in the history of medicine, this is a good book to lay the foundation.
Tidbits:
- Why the lack of medical science progress? Perhaps it was the church's focus on the soul, subordinating the body to the spirit (along with Galen worship (if dissection to prove Galen right, it was the anatomist's fault))
- dissection was not prohibited but was restricted to criminal bodies
- 1200s in southern Europe there was no separation between surgeon and physician, while in Paris these positions were differently licensed
- "The wish to bring dead crusaders back from the Holy Land for burial led to the custom of boiling up bodies to leave only the bones, and to the preservation of the heart of the deceased."
- there are passages that show the existence of surgical techniques (e.g. removing cataracts) in 9th century Indian medicine, but there is no evidence of further progress
- Galen did not provide many examples of human dissection and applied the results of animal dissection to humans (parallels to modern pharmaceutical research that gets a lot of hype... there's even a scientist whose twitter account is used just add "in mice" to the end of many news headlines hyping the latest findings in pharmaceutical testing)
- In 1572, Pare addressed the study of obstetrics, show the art of podalic version (turning a baby in the womb, to facilitate feet-first delivery)." What?!
- subtitle of one 16th century book: The Mirror of the Apothecaries and Druggists in Which is Demonstrated How the Apothecaries Commonly Make Mistakes in Several Medicines Contrary to the Intention of the Greeks... on the Basis of the Wicked and Faulty Teachings of the Arabs
- "Renaissance humanism benefitted the doctor more than the patient. The new learning hardly helped physicians to cure diseases. But it gave the medical profession an elevated sense of its proper dignity."
- thanks to the development of printing, writings popularizing health advice made up for the lack of institutional medical provision
- The forceps were developed in the mid-16th century, but their use did not spread because the design was kept a family secret
- the life table was developed in 1693 by the astronomer Edmond Halley
- because the patients medical history was so important, the common practice of postal diagnosis was perfectly reputable in the 18th century
- medical education in late 18th century Britain: Edinburgh University was cheap, had no religious restrictions, lectures in English, no obligation to graduate, and students only paid attended for those courses they desired
- surgery in the early 19th century: post-op infection meant that mortality for amputation was as high as 40 percent. "The surgeon's only answers to the excruciating pain attending all knife-and-saw work were skill and speed. In 1824, Astley Cooper took twenty minutes to amputate a leg through the hip joint; ten years later, James Syme was doing it in ninety seconds."
- medical fad of the 1800s: incising tongues as treatment to stammering
- demonstration of using laughing gas before pulling tooth was botched and the developer of ether began adding ingredients to color it and mask the smell, announcing he had discovered a new gas
- "Lister made a fetish of antisepsis but did not scrub his hands... and continued to operate in street clothes"
- nursing remained dominated by religious orders in the early 20th century. In Germany, out of a total nurse population of 75,000, only 3000 belonged to the professional Nurses' Association.
- By the 1920s, clouding of the cornea was being treated by transplantation, and thermocautery was introduced to repair detached retinas
- different development of medical specialization: in Britain, special disease/body part hospitals developed; in the US, hospitals developed to cater to particular ethnic groups rather than disease groups; in Germany and Austria, specialized departments within hospitals (rather separate institutions) were more likely to emerge
- hospitals for treatment rather than care of the dying were developed in the wake of optimism towards science and laboratory research
- most of the students at the alternative medicine Massachusetts Metaphysical College were mostly women who were excluded from regular medical education
- public health: by 1900, diagnostic labs had been set up in every state and in most major cities in the US, while the public health lab developed more slowly in Europe
- the importance of showing the mosquito as a vector for various diseases cannot be understated
- the mosquito experiments could not be done today. These studies required healthy individuals with no contact with the disease in question be bitten by an infected mosquito (there were volunteers for this!)
- anti-malarial campaigns were quite successful in the US and Europe (not needing constant long-term action, malaria was seemingly driven out after a decade). Malaria proved more resilient in less developed areas, most likely due to the endemic nature of malaria in those regions
- there was private funding for research on tropical diseases, mostly as a way to facilitate "imperial commerce"
- Freud held to the idea (through his last publication) of the importance of the repressed Oedipus complex
- pressure from the Rockefeller charity and professional associations led to a decrease in the supply of doctors. In 1910 4400 doctors graduated; by 1920 it was 3047
- Experiment that showed persistent anemia was due to digestive dysfunction: For 10 days, anemic patients were fed minced rare steak. Their blood showed no sign of improvement. At the same time, ordinary men were fed the same amount of steak. Their gastric contents were recovered through a stomach tube. These contents were liquified and fed through a stomach tube to the anemic patients. The patients' blood showed clear signs of regeneration after a few days.
- Experiment in endocrinology: It had long been known that castrating a rooster led its comb to atrophy; if the testes were then transplanted to another part of the body, this did not happen
- Sharing with serum and vaccine therapies the promise of scientific miracles, testicular implants enjoyed a vogue; monkey-gland implants were popularized in the 1920s; in the US, John Brinkley (1885-1942) made a specialty of implanting goats' testicles, promising his clients sexual rejuvenation and relief of high blood pressure.
- Injecting a woman's blood into a lab rat, if the woman was pregnant, the rat would go into heat (1929).
- electrocardiograph was invented in 1903
- various surgeries became vogue in 1920s and 1930s, tonsillectomies (vastly oversubscribed), hysterectomies, removal of sympathetic nerves, etc. Munchausen's syndrome (addiction to surgery) became a diagnosis. "No label seems to have been devised, however, for surgeons addicted to surgery."
- 1934, electron microscope had the same magnification of the best light microscopes. By 1946, it could magnify objects 200,000 times
- 1914, researchers at Johns Hopkins developed artificial kidney for dogs for dialysis. The 1940s saw the first workable dialysis machine for humans
- Cost projections of British NHS were way off: calculated annual cost was £170 million, in 1951 the actual cost was £400 million and in 1960 it was £726 million
- John Abernathy (1764-1831) was apparently in the habit of barking at fat ladies "Madam, buy a skipping rope"
- discussing the utility of medications Oliver Wendell Holmes (1809-94) "no families take so little medicine as those of doctors"
- difference in UK and US: in 1930s, 1 in 7 UK doctors were general practitioners (fewer than half of US were GPs), in 1980s, 65 percent of UK doctors were GPs, only 1 in 8 US doctors
- Lamaze (of Lamaze breathing) was a bit of a quack
- adhering to home births and rejecting orthodox medicine, the Faith Assembly religious sect in Indiana had a perinatal mortality (i.e. stillbirth or early neonatal death) was 92 times higher than Indiana as a whole (as of the books publishing)