Very funny but very profane, so do be aware of that.
The writers and voice cast all had so much fun with the characters, format, and concept. All sorts of historical figures and "Easter eggs" are sprinkled throughout the story, there's constant breaking of the fourth wall, and really silly but somehow still compelling characterization.
I'll say it again: The voice cast is AMAZING. I got so involved. If you love humor, alternate history, the 1960s and the space race, or radio theater, definitely give this a listen. (DON'T listen if swearing, smoking or "second base" is a deal-breaker.)
Nurse Nancy is a delightful hot mess of a main character, and I loved her and Ian's unconventional friendship. I was also really rooting for good ol' Ben, even if he is a bit of a square.
I feel this scratches a similar itch to Futurama, so if you like one you may like the other. (A certain character sounds almost the same in both productions, so that may be what drew my mind to the connection in the first place.)