The book description —“In 1965, neuroscientist Margot Sharpe meets Elihu Hoopes: the “man without a shadow,” who will be known, in time, as the most-studied and most famous amnesiac in history. A vicious infection has clouded anything beyond the last seventy seconds just beyond the fog of memory.”— gives us a clue that this novel is based on the case of HM, the real patient who became the most famous amnesiac in history. JCO acknowledges Corkin’s book on HM as her primary research source, and JCO’s fictional amnesiac, EH, is indeed spookily like HM in many of his responses to the world he lives in following the loss of his ability to make new conscious memories. Likewise, the laboratory environment and the memory tests EH is given (again and again, and every time new to EH) are well researched and accurate. However, EH is in no way like HM in his background, or his personality, and the neuropsychologists likewise are, thankfully, very fictional (I know this as I worked with the real HM when I was a young neuropsychologist!).
The moral and ethical issues that JCO delves into are thought-provoking, especially those related to research participant exploitation. The exploitation of junior researchers by senior researchers, especially in the 1960s and earlier, is by no means a new topic (although again, thankfully, part of EH’s story and not HM’s). JCO’s ability to get inside EH and view the world from his time capsule of 70 seconds, is masterful and believable. However, the twist in this story, the manipulative relationship Margot Sharpe, the neuropsychologist and ultimate leader of the EH research project, develops with EH is not believable (or too horrific to believe). But this is fiction after all, and as fiction is a fascinating tale of two lives, one blighted by physical damage to his brain, and the other blighted by her own obsession and loneliness.