FANTASTIC FOUR ANNUAL #2 (The Origin of Doctor Doom)
Stan Lee and Jack Kirby create an effective character study of a comic book villain, creating two stories that contrast past and future in a way that provides a fully comprehensive arc of that character's life.
The first story recounts the origin of Doctor Doom; Lee briliantly uses the present as a framing device, opening the story with the knowledge that Victor Von Doom will eventually look like a masked steel skeleton. The suspense of the story then becomes seeing him gradually look more and more like the figure at the beginning of the story, which we know he will eventually become.
The second story foreshadows the destiny of Doctor Doom; the arrival of the Time Traveller Rama-Tut allows certain details about Doom's future to be revealed, which create a nice arc between the first and second story; the arc progresses from a character's past, to their present, to their future.
What's even more interesting is how certain detail from the first story become integral to the second one, even further tying the two stories together. Thus, this nice duology creates an effective metaphor for how time destroys all things.