So what this is is a collection of the first isues of various Deadpool series, plus his very first appearance from New Mutants #98. Lots of stories begin, but none end. There are more writers and artists represented in this book than you can shake a stick at (and who goes around shaking sticks at writers and artists anyway? If you went up to Rob Liefeld at a convention and shook a stick at him, they'd call security ...) This isn't a book you read for the story, but rather to see the evolution of a character over the years.
With such a diverse cast of creative talent, this comes off as quite spotty in quality. Some of these number ones seem like series that I'd like to read more of, Deadpool Corps in particular. I've already read and reviewed the first volume (Dead Presidents) of the 2013 Deadpool series elsewhere. Overall, the impression is kind of meh. There are high points and low points, and the lack of closure on the stories gets a bit frustrating. It is fun to see the changes in the character over the years though. And I was also fascinated to compare Rob Liefeld's art from New Mutants #98 (1991) with his art from Deadpool Corps #1 (2010). It looks a LOT better in the latter title, partially due to Adelso Corona's inks, and partly due to Rob's improvement over the years, or at least he's gotten better at hiding his weaknesses (like, you know, feet.)
And I'm going to hate myself for mentioning this, but, when I was looking for this book on Goodreads, it came up with a looooooong list of Deadpool titles, one of which was Deadpool Kills the Marvel Universe. Somehow, my brain combined that title with a misreading of the title of this book, and came up with Deadpool Fists the Marvel Universe. Yeah. I don't think we'll be seeing that title from the House of Ideas anytime soon ...