This volume highlights the applications of contemporary concepts and techniques in medical genetics to the study of neurologic and psychiatric disorders. The contributors show how techniques such as linkage studies, mapping of human genes on chromosomes, and complete nucleotide sequencing of the human genome yield new insights into the pathogenesis of a wide range of conditions, including schizophrenia, manic-depressive illness, Alzheimer's disease, Huntington's disease, Down syndrome, and mental retardation.