Not well researched; writing average
I'm not terribly far into this book. Not sure I will finish it, let alone the series. I can tell you that the author should have read The Hot Zone, as the barest of minimums, before embarking on his Ebola-pocalypse adventure. The most basic details of biology are mistaken.
Ebola is a virus. Therefore, it doesn't matter how many antibiotics are thrown at it. If he'd chosen Bubonic Plague (bacterial), he could have kept the many mentions of antibiotics. But, he didn't, so he earns my forthright review.
The actual construction of the writing is ho-hum. There's a story being told, but hard to get excited over any of it when distracted by the traps in which so many self-published authors stumble; lack of editing (beyond basic proofreading by betas), lack of pacing or flow, too much telling instead of showing, improper use of grammar (admittedly better than way too many Amazon self-pubs), not effectively using writer's tools to set plotting tone (background, foreshadowing, catalyst, etc).
Characters aren't the worst, just two dimensional. They have little to no background beyond introduction and we're already 3 or more weeks into the outbreak. They are also beyond dumb. Like having a knife fight with looters while wearing full hazmat gear. Or using fists to pulverize the face of a bad guy after recognizing a sign of infection in his eyes, also while wearing said full hazmat.
The reporter that supposedly kicks off city quarantine is a freaking idiot who kind of deserves ebola, but will probably end up some kind of folk hero, if she's ever heard from again. She pulled a disappearing act.
If you're not finicky and are just looking for a book or series to pass the time, you'll probably do just fine with American Quarantine. If you're more discerning, wanting well-researched material and characters who are enjoyable to hang out with and even admire, this read will likely drive you at least a little bonkers. Especially, if you are truly literary minded and want more than mediocre to average in the way an author handles himself/herself. This story has promise, but would require substantial rewickering to reach for 4, or even 5, stars. Though, it could be done.