Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categorical data, while other aspects of this field are unique to survival data. This text employs numerous actual examples to illustrate survival curve estimation, comparison of survivals of different groups, proper accounting for censoring and truncation, model variable selection, and residual analysis. Because explaining survival analysis requires more advanced mathematics than many other statistical topics, this book is organized with basic concepts and most frequently used procedures covered in earlier chapters, with more advanced topics near the end and in the appendices. A background in basic linear regression and categorical data analysis, as well as a basic knowledge of calculus and the R system, will help the reader to fully appreciate the information presented. Examples are simple and straightforward while still illustrating key points, shedding light on the application of survival analysis in a way that is useful for graduate students, researchers, and practitioners in biostatistics.
I am a professional software developer with an interest in biostatistics. I picked up this book to gain a deeper understanding of Kaplan-Meier graphs and accompanying theories around them. This book went into many more details than I found accessible. Nonetheless, it introduced me to hazard plots and hazard analysis – a concept that I was able to apply to my work.
Mathematics/statistics and R code are used heavily in this book. To garner the full value of this work, the reader should really explore the R code on her/his own computer. For use this way, Moore presents the appropriate concepts, commands, outcomes, and interpretations.
The appropriate audience for this work is the community of biostatisticians. Those in the general population – or even the scientifically literate population – who, like me, have only a tangential interest will likely not receive this work’s full value. Nonetheless, there are some nuggets that can still be gleaned. I unfortunately lack the competence to critically judge Moore’s science.