This third volume of Hiroya Oku's seinen manga Inuyashiki features an unexpected left turn into truly nasty subject matter that is delivered vividly and viciously by the writer/artist. It is perhaps the single most emotionally engaging and distressing comic I've read since Chris Ware's incredible and tremendously depressing fictional biography, Lint (Acme Volume 20), though this volume of Inuyashiki is not a realistic drama, but a wicked amalgam of body horror, science fiction, yakuza, salaryman, and post-human genres presented in an equally oppressive and impressive page-turner.
Few villains in comics that I've ever come across radiate as much menace as the Yakuza villain Jima depicted herein. His actions and design yield one of the most palpable depictions of evil I've ever seen in a comic, and I cannot think of any illustrated villain ever having quite this much immediate presence. Bravo, Oku-san.
I hope the series doesn't collapse in later volumes like those Tsutomu Nihei mangas did, but this volume is conclusive enough that future issues won't ruin the virulent and superbly manipulative story within, and the first two volumes are almost as good.
Inuyashiki is recommended for fans of History of Violence, Robocop, Takeshi Kitano (a top 10 favorite director of mine), Tezuka's MW, and the best Death Wish movie (Part II, the unrated edition).
Inuyashiki Vol. 3 is a harrowing and confrontational manga, and moments after finishing it, I purchased the rest of the series.
Update: I finished reading the entire manga. The perils, horror, vividness, and atmosphere on display in Volume 3 are not reached again--and some of the books (esp. 6 & 9) are too repetitive/lacking in tension---but the piece works as a whole and is recommended.