Smallpox was a far greater killer than the plague, but is fading from memory after its successful elimination. This well-written book covers the history and the suspenseful drive to risky variolation, safer vaccination, and the eventual end to the scourge. Smallpox killed about 1/3 of its victims and is easily spread by inhalation. Names like D.A. Henderson are now not well known, but should be, for freeing humanity of its greatest viral killer. At a small cost, smallpox was isolated and destroyed via efforts of the WHO and member states, including the USSR and USA- who managed to cooperate in this one vital area during the Cold War.
The later part of this book focuses on the aftermath of the seeming end of smallpox. A secret and illegal Soviet biological weapons program worked to develop a super-smallpox and continued through the dismemberment of the Soviet Union. The US and Soviet Union held the only two remaining live smallpox viruses, ostensibly for scientific research.
For decades, much of the world has demanded these final stocks be destroyed, finally freeing the Earth of the killer. Yet, the superpowers have been caught in the classic prisoner's dilemma, unsure the other would really destroy all their stocks, given the possible military advantage. Some scientists want to retain the virus in anticipation that another virus, such as monkeypox, will evolve into the void left by smallpox. Concerns about mislaid smallpox cultures, forgotten in a vial in some academic freezer, or held in secret by a rogue state, colored the debate. In fact, this book touches on the topic of Iraq, which was thought to have WMD, likely including smallpox, which was one of the reasons for the Second Iraq War. Lastly, there is a fear smallpox could be reintroduced by digging up a victim buried in the permafrost.
The book ends on a bittersweet note. Eradicating smallpox was an epidemiological grand achievement. But, in the unlikely event the American or Soviet stocks are ever breached, or smallpox is released by a terrorist, the world is less prepared than it was because immunity fades quickly, and the world has a dreadfully low vaccination supply. Could smallpox be reintroduced? If so, a smallpox pandemic might lead to tens or even hundreds of millions of deaths. Which is why I think the final known viral stocks should be destroyed.