This took a while to complete! Minsky's writing is very clear and conversational, but the material is extremely dense. Both the breadth and depth of the material covered is pretty incredible: from defining what a "machine" is in the sense of computer science (and the general idea of computability a la Turing) and simple finite state machines, to symbolic generation of sequences (Emil Post and Kleene).
Most of the content revolves around mathematical representations using the Latin and Greek alphabets. However, Minsky defines all terms and the material builds upon itself so that you can work out every single problem yourself with this book and pencil and paper (and a whole lot of quiet time). No other reference is needed. It reminds me of Knuth's The Art of Computer Programming in this regard.
This book will not teach you how to program computers, but it is certainly possible to make connections between the extremely abstract and fundamental subjects in this book and certain areas of practical computing, such as compiler development.
Probably the most valuable thing a modern reader will get out of this book is an understanding of the fundamentals of computer science which were largely fleshed out in the early 1900s. Multiple overlapping ideas and approaches (Turing, Post, Kleene) are all woven into a single narrative so that you end up approaching ideas like recursion in several different ways. You have to admire the work that went into this book!
I think it's worth thinking about computability at least once. For a much easier introduction, I recommend "The Annotated Turing" by Charles Petzold (yes, the same Petzold who authored the colossal tome "Programming Windows"!)