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528 pages, Paperback
First published January 1, 2009
"In fact, both the dopamine and the serotonin theories were based on indirect evidence, often from animal experiments, mainly the effects of drugs on the brains of animals that could be killed for the purposes of science. Researchers realized that direct observation of abnormal biochemistry in the brains of living patients would be necessary to firm up their theories. Obtaining this evidence proved difficult because the brains of patients could not be observed directly and, in any case, the drugs the patients were by then inevitably receiving interfered with the very biochemical processes that researchers wanted to study. Although some evidence has emerged to support the role of dopamine in psychosis, direct support for the serotonin hypothesis has remained elusive to this day. Nonetheless, the chemical imbalance theory of depression has continued to be enthusiastically promoted in drug advertisements (sometimes targeted directly at consumers rather than professionals: ‘Celexa helps to restore the brain’s chemical balance by increasing the supply of a chemical messenger in the brain called serotonin’) and by the popular press. Perhaps this is partly because the idea is so easy to understand, but it is also because this type of explanation for mental illness serves the interests of biological-orientated psychiatrists and drug companies very well."
"Genetic researchers in the meantime have increasingly turned to new technologies in the hope of finding evidence to support their theories, and especially to new molecular techniques that have become available over the last twenty years. Unlike the methods of behavioural genetics that we have considered thus far, these techniques can show how particular types of behaviour and experience are related to specific genes, coded in sequences of bases on stands of DNA and located on specific chromosomes.
Before considering this development, it is worth reminding ourselves that genes cannot determine human characteristics directly. Rather, they control the synthesis of proteins in the body, which in turn helps to determine the way that the individual grows and develops. At each stage in this complex and as yet incompletely understood process, there are opportunities for the environment to influence what is happening. In short, there is a long and incredibly complicated causal pathway running from the DNA we inherit from our parents to our behaviour in adulthood and, under these circumstances, it is perhaps naive to imagine that there are genes ‘for’ any particular trait.
[...]
Since the very earliest days of professional psychiatry, researchers have systematically exaggerated the extent to which serious mental illness is caused by genes, and underestimated the importance of environmental influences. Recent evidence collected by molecular geneticists gives us no reason to doubt this conclusion, because the only findings that have proved to be even marginally replicable concern genes that confer only a very small risk of psychosis and which are absent in the majority of patients (and even these findings are questionable, given the results of the recent large European study). If there were any genes with more direct and marked effects, they would have certainly been discovered by now, so we can confidently assume that they do not exist.
[...]
I should perhaps make it clear at this point that I am not opposed to research on the way that genes influence behaviour, but it seems to me that resources should be allocated in proportion to the likely benefits that will be obtained by individuals and society.
In this context, it is important to note that no patient, not a single one, has ever benefited from genetic research into mental illness, although many have been indirectly harmed by it (because it has discouraged the development of adequate services for patients and, during one shameful period, was used to justify their slaughter). No effective treatments have so far been devised on the basis of genetic information and, given what we now know, it seems very unlikely that further research into the genetics of psychosis will lead to important therapeutic advances in the future. Indeed, from the point of view of patients, there can be few other areas of medical research that have yielded such a dismal return for effort expended."
"Importantly, this research has shown that recovery is a multifaceted phenomenon. For example, some patients are liberated from their symptoms by their drug treatment but continue to struggle with severe social disabilities, whereas others function perfectly well despite the persistence of voices and unusual beliefs. It is therefore difficult to devise a universally acceptable definition of recovery, but defining it merely in terms of symptoms – still meeting the diagnostic criteria according to the DSM or the ICD – seems hopelessly narrow. Patients more often highlight the importance of improved quality of life, the sense of being empowered to rebuild their relationships and careers, improved self-esteem and hope for the future.
Recovery must therefore be seen as an evolving and unavoidably subjective process. William Anthony, a psychologist specializing in the rehabilitation of chronically disabled patients, has described it as ‘A deeply personal, unique process of changing one’s attitudes, values, feelings, goals, skills, and/or roles. It is a way of living a satisfying, hopeful, and contributing life, even with limitations caused by the illness. Recovery involves the development of new meaning and purpose in one’s life as one grows beyond the catastrophic effects of mental illness.’ Anthony has argued that the evidence-based medicine movement, with its emphasis on randomized controlled trials in which the outcome measured is usually symptoms, has had little impact in psychiatry precisely because it has failed to seek evidence that is meaningful to patients. Instead of conventional trials, he suggests that researchers should focus on those domains of functioning that patients think are most important (for example, quality of life), using methods (for example, interviews) that allow subjective outcomes to be measured, administered as far as possible in real-life settings. He also argues that researchers should make more effort to study the impact of the therapeutic relationship."