I thoroughly enjoyed the original Mass Effect Trilogy, but never got around to playing Andromeda (I have it now, and will get around to it after my playthrough of the Legendary Edition), so I don't know how much this really ties in to that game apart from mentioning the Andromeda Initiative, but this was a fairly engaging story. I have read several volumes of Mass Effect comics and novels, and can safely say that this story is better executed than a lot of other comics (I haven't had an issue with any of the novels I have read). It does still require you to have quite a bit of knowledge of the world (or galaxy or whatever) and its inhabitants (like the various species and their governments, what biotics are and how they work, and the nature of interstellar travel and Mass Relays, so it still doesn't quite work off completely cold if you aren't a gamer, but as a media tie-in book, you probably weren't going to pick up a Mass Effect comic if you haven't played the game, and it could be manageable with a guide (either a person or a webpage) if you did so. I think what made this a bit more successful than some other books was a slightly larger cast of characters and some more varied locations and antagonists, that made it a bit more like the games. In any case, this did pique my interest a bit more in finally getting around to playing Andromeda.