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336 pages, Hardcover
First published June 19, 2018
... A woman of child-bearing age who was born by C-section, fed formula, or received antibiotics at any point in her life—or if this is true of her mother or grandmother—does not have the important bacterial species B. infantis.... if any one of those scenarios applies to you, your mother, or your grandmother ... you no longer harbor B. infantis in your body and are therefore unable to pass it on to your children. ... The demise of the bacterium coincides most eerily with the perplexing increase in all of these diseases of autoimmune origin, like atopic dermatitis, food allergies, environmental allergies, colic, asthma ... ... ... Indeed, atopic dermatitis in babies born between 1960 and 2000 has risen fivefold, and type 1 diabetes incidence in children has also increased fivefold. (p99)The author goes on to stress that the lack of these microorganisms can have effects later in adult life.
... 97 percent of American babies do not have B. infantis in their gut. On the other hand, the majority of infants in less-industrialized countries have a gut dominated by Bifidobacteria. (p101)
... down the line the implications are profound for preventing chronic diseases like cancer, especially those in the gastrointestinal tract. Bear in mind that the United States has seen an alarming rise in the incidence of colon and rectal cancers in people in their twenties and thirties, something previously unheard of.The book then explores the surprising ways emulsifiers act on our microbiota. Emulsifiers are found in almost all processed foods and show up on labels as xanthan gum, carrageenan, polysorbate 80, guar gum, and soy lecithin.
The emulsifiers that we have tested are disrupting the composition of the gut microbiota, they're changing the species of bacteria, and they are doing it in a way that promotes inflammation ... (p122)Then the narrative moves on to artificial sweeteners. In the following excerpt a connection between ingestion of sweeteners and glucose intolerance is noted. Glucose intolerance is a key marker in diagnosing diabetes.
The researchers also did a small-scale study in humans and for one week gave artificial sweeteners in amounts allowed by the FSA to people who had never previously consumed artificial sweeteners. The researchers found that amount was enough to alter the subjects' gut bacteria and induce glucose intolerance in more than half the participants. (p127)The book's narrative groups all these together forming the following conclusion.
And as we piece this puzzle together, antibiotics, emulsifiers, artificial sweeteners, and our highly processed diets, which are missing vital components, are likely resulting in the elimination of all but the most hearty, aggressive strains of bacteria, which are potentially encroaching on the intestinal mucosal lining, causing inflammation and eventual disease. (p129)Then the book moves on to a really scary subject, endocrine-disrupting chemicals (EDCs). They are scary because they are biologically active in extremely small doses. One famous example is BPA of which 99 percent of Americans have detectable levels in their blood. The FDA has required that BPA not be used the manufacture of baby bottles, so the plastic industry has substituted BPS, a compound that this book says is similar to BPA. Now levels of BPS in the blood are on the rise.
...female rodents exposed to BPA in the womb exhibit risk factors for breast cancer and as they age are developing full-blown carcinomas in the mammary gland. (p148)Some other examples of endocrine-disrupting chemicals are TBT and other organotins which are used in the lining and sealing of food cans.
... low-dose fetal exposure in mice led to an increase in body weight, liver weight, and abdominal fat mass when those mice became adult males. (148)
... organotins change how the body responds to calories. ... ... animals that we treat with these chemicals don't eat a different diet than the ones who don't get fat. They eat the same diet ... They're eating normal food, and they're getting fatter ...(p151)The book goes on to explain that tests on rats have shown this effect can be passed on to subsequent multiple generations. If the human body response is similar, the following are the results.
Your maternal grandmother was exposed to TBT while your mother was in the womb. While your mother was developing as a fetus, you were developing as germ cells within her ovary. This means that not only was your mother exposed to the chemical, but you were exposed to it as a germ cell. What's even more alarming is that your future children (the fourth generation) are also affected, even though your children had no direct exposure to the chemical. (p153)I'm sure there are many people willing to conclude that the obesity epidemic has nothing to do with overeating. It's all those chemicals.